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Cell Biology / Development (genes) PhD Projects, Programs & Scholarships

We have 76 Cell Biology / Development (genes) PhD Projects, Programs & Scholarships

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  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019

Funding Type

PhD Type

The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Engineering tRNA neochromosomes in yeast
  Prof P Cai, Prof D Delneri
Applications accepted all year round

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  To address the functional significance of circadian clock genes in regulating the “stemness” and tumorigenesis of mammary cells
  Prof C Streuli, Dr Q-J Meng
Applications accepted all year round

Funding Type

PhD Type

Circadian (24 hourly) rhythms generated by our intrinsic biological clocks play critical roles in regulating physiology and behaviour.
  Functional coronary artery disease genetics: investigating the role of the candidate gene in models of In vivo cardiovascular disease
  Dr G Douglas, Prof K Channon
Application Deadline: 26 July 2019

Funding Type

PhD Type

Despite significant advancements in its treatment coronary artery disease is the leading cause of death in both the UK and world wide, accounting for over 66,000 deaths in the UK each year.
  An intelligent scheme to identify novel drug targets through analysing the DNA repairome in drug resistant cancer?
  Research Group: Biomedical Research Group
  Prof C Parris
Applications accepted all year round

Funding Type

PhD Type

Research Group. Biomedical Research Group. https://www.anglia.ac.uk/science-and-engineering/research/institutes-and-groups/biomedical.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round

Funding Type

PhD Type

Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  FGFR signalling in breast cancer
  Dr A Chioni
Applications accepted all year round

Funding Type

PhD Type

Growth factors are used during development to convey messages that tell cells to divide, survive, migrate and adopt a particular fate.
  Control of tissue growth and cancer by the Hippo pathway
  Dr K. Harvey, Dr C Poon
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  Defining diets to treat inborn errors of metabolism
  Dr T Johnson, Dr M Piper
Applications accepted all year round

Funding Type

PhD Type

Fully funded PhD scholarships are available for both Australian and international students through the School of Biological Sciences and Monash University.
  Transcriptional responses to cellular stress
  Dr PG Grzechnik
Applications accepted all year round

Funding Type

PhD Type

Position for a PhD student is available in the group of Dr Pawel Grzechnik at the University of Birmingham. The aim of the project is to understand how eukaryotic cells remodel RNA biology in order to survive stress generated by pathological conditions and external stressors.
  MASTERS BY RESEARCH PROJECT: Developing Drosophila as a model to study the molecular and behavioural changes underlying Parkinson’s disease
  Dr J Hodge
Applications accepted all year round

Funding Type

PhD Type

Start 23 September 2019. This MSc by Research is a laboratory-based project which offers the exciting opportunity to spend 1 year in one of our State-of-the-Art laboratories (plus 1 year thesis writing) at the University of Bristol and experience life as a researcher.
  Signalling pathways maintaining human embryonic stem cells
  Prof S J Kimber, Prof D Brison
Applications accepted all year round

Funding Type

PhD Type

The aim of this project is to determine the function of novel genes predicted to have critical roles in preimplantation human development and in disease in later life.
  The analysis of genetic and environmental contributions to the risk of congenital heart disease
  Dr S Loughna, Prof J D Brook
Applications accepted all year round

Funding Type

PhD Type

According to BHF statistics 12 babies are born with heart defects in the UK each day and more cases. are diagnosed in later life.
  Molecular dissection of activity-dependent neuronal signalling pathways using quantitative proteomics
  Dr M Collins
Applications accepted all year round

Funding Type

PhD Type

Recent proteomic investigations have identified several thousand proteins in biochemically purified synapses and have uncovered multiprotein complexes essential for synapse function.
  Understanding the role of cohesin and the impact of structural variation on gene expression regulation in the 3D genome
  Prof N J Gooderham, Dr R David
Application Deadline: 31 July 2019

Funding Type

PhD Type

The genome has a three-dimensional (3D) configuration and is interconnected with nuclear architecture, both of which are critical for gene regulation and cell functionality in normal physiology and disease.
  The role of endogenous retroviruses in human health and disease
  Dr G Magiorkinis
Applications accepted all year round

Funding Type

PhD Type

More than 10 years have passed since the first high quality (nearly) complete version of the human genome and we are still exploring its functionality.
  Genetic changes underlying colorectal cancer initiation and progression
  Assoc Prof V Whitehall
Application Deadline: 11 August 2019

Funding Type

PhD Type

In the Gastroenterology Laboratory we are interested in characterising the genetic changes underlying the progression of pre-cancerous colonic polyps to colon cancer.
  Cold Response Dynamics in the Maize Leaf Growth Zone
  Dr H AbdElgawad, Prof B Gerrit
Application Deadline: 11 August 2019

Funding Type

PhD Type

Early spring cold is a major limiting factor for maize cultivation in North-Western Europe. Typically, cold spells are only transient, and it is known that the capacity of varieties to recover strongly determines their final yield.
  The Role of LIM Domain Only Proteins in Neuroblastoma
  Dr M Hoogenkamp
Applications accepted all year round

Funding Type

PhD Type

Person Specification. An Upper Second Class Honours Degree (or equivalent) in a relevant study or Master’s degree is expected. Prior experience in cell and molecular biology is an advantage.
  Creating “super” regulatory T cells to combat rejection, GVHD and autoimmunity through retroviral gene manipulation
  Dr N Jones, Dr S Lee
Applications accepted all year round

Funding Type

PhD Type

Research interests/description of main research theme. Foxp3+CD25+CD4+ regulatory T cells (Treg) have been shown to be essential for the induction of tolerance to foreign organ transplants in experimental models.
  Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
  Dr M Soller, Prof F Mueller
Applications accepted all year round

Funding Type

PhD Type

Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017).
  Kinase regulation of HOX transcription factors – a potential target in cancer?
  Research Group: Institute of Cancer Therapeutics
  Prof R Morgan, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

The HOX genes are a family of transcription factors that have a number of important functions in cancer, including cell survival and metastasis.
  Molecular mechanisms controlling cardiac fibroblast proliferation during cardiac fibrosis
  Dr M Bond
Applications accepted all year round

Funding Type

PhD Type

Applicants are invited for a new self-funded PhD studentship to study the molecular mechanisms of cardiac fibrosis. Myocardial fibrosis is a significant global health problem associated with nearly all forms of heart disease.
  Novel anti-inflammatory mechanisms of cyclic-AMP in vascular smooth muscle cells
  Dr M Bond
Applications accepted all year round

Funding Type

PhD Type

A self-funded PhD studentship is available at the University of Bristol to study novel anti-inflammatory mechanisms of cyclic-AMP in vascular disease.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Evolution of vertebrate blood vessels
  Dr T Takahashi, Dr S Herbert
Applications accepted all year round

Funding Type

PhD Type

The blood vessels are the core elements of the circulatory system of animals, and their malfunction is related to most human diseases including cancer and heart attacks.
  Genetic and immunological basis of rare primary immunodeficiency diseases
  Dr P Arkwright, Dr T Briggs, Prof T Hussell
Applications accepted all year round

Funding Type

PhD Type

Objective. To understand the genetic and explore the functional immune basis of rare primary immunodeficiency diseases. Background.
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