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Cell Biology / Development (information studies) PhD Projects, Programs & Scholarships

We have 162 Cell Biology / Development (information studies) PhD Projects, Programs & Scholarships

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  SWBio DTP PhD project: Ancestral functions of genes regulated by imprinting in mammals
  Prof A Ward, Prof R N Kelsh, Prof J Wolf
Application Deadline: 2 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
  Inhibition of PRMT5 as a cancer therapy
  Dr K. Sheppard
Applications accepted all year round

Funding Type

PhD Type

Targeted therapy has had profound impact on outcomes for cancer patients.
  Understanding how the NuRD complex regulates 3D genome organization using a combination of single-molecule super-resolution imaging and single cell biology
  Prof E D Laue
Applications accepted all year round

Funding Type

PhD Type

The spatial organisation of the genome is known to play an important role in regulating RNA transcription to effect cell-type-specific gene expression programs, and to control the differentiation of embryonic stem (ES) cells.
  Precision Medicine DTP – Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets
  Research Group: Centre for Cardiovascular Science
  Dr BC Conway, Dr T Chandra, Dr D Ferenbach
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), at which point patients require dialysis or transplantation.
  How does amino acid metabolism affect tumour growth?
  Dr L. Cheng
Applications accepted all year round

Funding Type

PhD Type

The effect of diet on tumour growth is hotly debated but poorly characterized. Due to the heterogeneous nature of the tumours, dietary studies in patients with varied genetic background often led to inconclusive outcome.
  Metabolic rewiring in liver cancer: Role of oxidative stress and the Nrf2 pathway
  Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Many of the major risks factors for developing liver cancer such as alcohol, obesity, smoking and toxin exposure share in common a role for oxidative stress.
  Predicting the development of oral cancer
  Dr C Darido
Applications accepted all year round

Funding Type

PhD Type

Human head and neck cancer is a devastating disease with poor survival rates.
  RNA Methylation in normal and malignant blood development
  Dr L. Kats
Applications accepted all year round

Funding Type

PhD Type

As is the case with DNA and histones, RNA can also be modified and indeed more than 100 chemical groups that decorate all four canonical RNA nucleotides have been described.
  Watching the Hippo pathway in real time in growing organs
  Dr K. Harvey
Applications accepted all year round

Funding Type

PhD Type

A new frontier in biomedical research will involve watching individual proteins work in real time, in living organs. Traditionally, researchers have drawn conclusions about gene function using indirect techniques that only allow us to infer what a gene normally does, without actually watching it work.
  EASTBIO Optimising breeding strategies in aquaculture using molecular marker information
  Dr C Haley, Dr P Navarro, Dr S Knott, Dr RP Pong-Wong
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute. Overview. Aquaculture is a growing industry that provides a sustainable source of high-quality protein.
  An exploration of the links between mitochondrial function and splicing regulation. PhD in Medical Studies (SWBio DTP)
  Dr L Harries
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Professor Lorna Harries, College of Medicine and Health, University of Exeter. Additional Supervisors. - Professor Mark Lindsay, Department of Pharmacy and Pharmacology, University of Bath.
  Modelling memristive artificial neurons
  Prof S Saveliev, Dr P Borisov
Applications accepted all year round

Funding Type

PhD Type

Does the brain operate as a computer? In short the answer is no, but why? We use logic when thinking and coming to a decision by linking events in a causal relationship.
  SWBio DTP PhD project: Constrained evolution – possibilities and impediments in pigment patterning
  Prof R N Kelsh
Application Deadline: 2 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
  Precision Medicine DTP - Modelling Sex Dependent Differences in Human Liver Disease using Stem Cell Derived Models and Organ on a Chip Devices
  Research Group: MRC Centre for Regenerative Medicine
  Dr D Hay, Prof P Saunders
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Metabolic syndrome is a cluster of conditions, which include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
  Can genetics-led immunologic investigation identify novel common regulators shared across immune-mediated inflammatory diseases? #NDORMS-2020/2
  Dr L Chen, Prof P Bowness
Application Deadline: 10 January 2020

Funding Type

PhD Type

Liye Chen. https://www.ndorms.ox.ac.uk/team/liye-chen. Paul Bowness. https://www.ndorms.ox.ac.uk/team/paul-bowness. Immune-mediated inflammatory diseases (IMIDs) are a group of incurable diseases that share inflammatory pathways and cause substantial personal and socioeconomic burdens.
  Cellular cross-talk at the perivascular niche and the blood brain barrier
  Prof B Hogan
Applications accepted all year round

Funding Type

PhD Type

Much research on vasculature has focussed on the endothelial cells that line functional vessels, however the milieu of cells that surround vessels (mural cells) play important and under-appreciated roles in homeostasis and disease.
  Fueling chemotherapy resistance in triple-negative breast cancer
  Dr K Brown
Applications accepted all year round

Funding Type

PhD Type

Triple-negative breast cancer (TNBC) is a molecularly heterogeneous group of diseases defined by the lack of estrogen receptor (ER), progesterone receptor (PR) and absence of human epidermal growth factor receptor-2 (HER2) amplification.
  The Hippo pathway and Yap1 in vascular growth control in development and disease
  Prof B Hogan, Dr A. Cox
Applications accepted all year round

Funding Type

PhD Type

Lymphatic vessels play roles in the drainage of tissue fluid, trafficking of immune cells and the metastatic spread of cancer.
  Understanding the mechanisms of neuroendocrine tumour response to radionuclide therapy
  Prof R Hicks, Assoc Prof C Cullinane
Applications accepted all year round

Funding Type

PhD Type

Neuroendocrine tumours (NET) represent a heterogeneous group of tumours that arise in specialized cells found throughout the body.
  The epigenetics of Parkinson’s disease: searching for novel drug targets. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr A Migdalska-Richards
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Anna Migdalska-Richards, Institute of Clinical Biosciences, College of Medicine and Health, University of Exeter.
  The influence of JAKMIP1, a key risk gene for autism, on neural circuit function. PhD in Medical Studies (MRC GW4 BioMed DTP)
  Dr A Oguro-Ando
Application Deadline: 25 November 2019

Funding Type

PhD Type

Supervisory team. Dr Asami Oguro-Ando, The Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter.
  Endothelial receptor antagonists in experimental models of pulmonary hypertension: Cellular and right ventricular studies.
  Dr D Welsh, Dr Y Dempsie
Applications accepted all year round

Funding Type

PhD Type

Project reference number. SHLS19004. Pulmonary hypertension (PH) is a general name for a group of progressive vasculopathies of the pulmonary vasculature.
  Characterizing the heterogeneity of stem cells in the normal breast and breast tumours
  Dr A Ucar, Prof K R Brennan
Applications accepted all year round

Funding Type

PhD Type

Tissue-restricted stem cells are crucial in supporting the development and maintenance of normal tissues. This is also true for tumours, as only a small population of tumour cells, which are known as cancer stem cells, have the unique stemness features and tumour-initiating capacity.
  Cutting off the fuel supply to calcium pumps in pancreatic cancer: a novel therapeutic strategy
  Dr J Bruce, Prof K Williams, Dr A P Gilmore
Applications accepted all year round

Funding Type

PhD Type

Background and Rationale. Pancreatic ductal adenocarcinoma (PDAC) has the poorest survival and limited treatment options. Therefore, the search for novel therapeutic targets and drugs designed to selectively kill PDAC cells must remain a central research strategy.
  Comparative studies of wound and cancer inflammation in plants and animals
  Prof P B Martin
Applications accepted all year round

Funding Type

PhD Type

All organisms need to be able to repair wounds. A key aspect of this is combating the potential for infection when barrier layers are breached by tissue damage.
  Structure-function studies of Coxiella burnetii O-antigen biosynthesis. PhD in Biosciences studentship (SWBio DTP)
  Dr N Harmer
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Prof Nicholas Harmer, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Dr J Boyes
Application Deadline: 25 January 2020

Funding Type

PhD Type

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Characterisation of in vitro models of human salivary glands and their use in functional studies
  Dr L Bingle, Prof C Bingle
Applications accepted all year round

Funding Type

PhD Type

Saliva is produced by three pairs of major salivary glands and multiple minor glands in the lips, associated with the tongue and also with the palate.
  Precision Medicine DTP – Using Omics to Understand the Genes and Pathways Underlying Alcohol Use Disorder
  Research Group: Centre of Genomic and Experimental Medicine
  Dr K Evans, Dr T-K Clarke, Dr S Glerup
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Alcohol use disorder (AUD) is a chronic relapsing brain disease characterised by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using alcohol.
  Expanded potential stem cells for regenerative medicine, immunotherapy, and biotechnology
  Prof P Liu
Applications accepted all year round

Funding Type

PhD Type

Embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells) are pluripotent and thus hold great promise in regenerative medicine, studying disease mechanisms and drug discovery.
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