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Cell Biology / Development (php) PhD Projects, Programs & Scholarships

We have 39 Cell Biology / Development (php) PhD Projects, Programs & Scholarships

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  An improved C. elegans model of Alzheimer’s Disease to monitor neuronal signalling activity
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen, Dr S Clapcote
Application Deadline: 31 January 2020

Funding Type

PhD Type

Alzheimer’s Disease (AD) is one of the most common form of neurodegenerative diseases known today, affecting approximately 50 million people worldwide.
  Understanding amyloid aggregation mechanisms of alpha- and gamma synuclein in vitro and in vivo
  Research Group: BBSRC White Rose DTP
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

A key pathological hallmark of synucleopathies, including Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS), is the formation of cytotoxic alpha-synuclein and gamma-synuclein aggregates respectively, that lead to neuronal cell death.
  A 3D in vitro model of wound healing incorporating skin, nerves and immune cells
  Dr A M Rajnicek, Prof H M Wilson
Applications accepted all year round

Funding Type

PhD Type

Diabetes, paralysis, being bed ridden and other conditions can result in chronic wounds that fail to heal, with significant personal consequences for patients and an annual cost of £4.5-5.1 billion annually (Guest et al., 2015) to the National Health Service.
  Development of ex vivo tissue culture models for developing next-generation biomaterial scaffolds for acellular regenerative medicine.
  Prof I Gibson, Prof N Vargesson
Applications accepted all year round

Funding Type

PhD Type

Bone repair and regeneration can be influenced by various guidance cues, including pharmacological cues, hypoxia environment and chemical cues released from scaffolds [1-3].
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Applications accepted all year round

Funding Type

PhD Type

Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  Investigating how the levels of queuine, a novel micronutrient, are associated with human ageing and brain health
  Dr B Green, Prof G Hardiman
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Queuine is the only micronutrient that directly affects translation efficiency and accuracy in eukaryotes, with roles in metabolism and healthy-aging of the brain.
  Rewiring of host cell protein complexes by pathogen effectors - mass spectrometry-based methods and applications in infection biology
  Dr B Collins, Prof J Bengoechea, Dr G Schroeder
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Bacterial pathogens, such as Klebsiella pneumoniae and Legionella pneumophila, residing inside host immune cells such as macrophages, must subvert host cell defences in order to avoid destruction.
  Understanding Biofilm Formation in the Domain Archaea
  Dr J Megaw, Prof B Gilmore
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Biofilms - structured and organised microbial communities - represent one of the most successful forms of life.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  EASTBIO - An integrative approach to understanding the mechanobiology of liver regeneration
  Dr M Bernabeu, Prof N Henderson
Application Deadline: 5 January 2020

Funding Type

PhD Type

The liver has a unique ability to regenerate [1], however in many cases of chronic liver disease this regenerative capacity is overwhelmed.
  Precision Medicine DTP - Analyzing network formation during brain tumour initiation
  Dr D Sieger, Prof P Uhlén
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. High grade brain tumours (HGBTs) represent a complex and devastating disease and are posing an unmet clinical need. These tumours resist multi-modal therapies and survival times are only 15 months on average.
  Precision Medicine DTP - Comprehensive study of miRNAs biogenesis in human cancer
  Dr G Michlewski, Dr C Kutter
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. MicroRNAs (miRNAs) are short non-coding RNAs ~22 nt in length that function as important regulators of gene expression1.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - Harnessing plasticity to repair spinal cord injury
  Dr T Becker, Prof C G Becker, Prof A El Manira
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. After a spinal cord injury in the zebrafish, lost neurons are replaced and axonal connections re-established (Tsarouchas et al., 2018).
  Precision Medicine DTP - How do IFITM proteins regulate the Interferon Related DNA-damage Resistance Signature (IRDS) and clinical outcomes in cancers of high unmet clinical need?
  Dr R Sloan, Prof K Ball, Dr S Wilson
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Interferon Induced Transmembrane proteins (IFITMs) are a family of innate immune membrane proteins that can inhibit viral infection at cell entry (e.g.
  Precision Medicine DTP - Illuminating roles of Wnt/b-Catenin signalling in nonalcoholic fatty liver disease (NAFLD)
  Research Group: MRC Centre for Regenerative Medicine
  Dr K Kaji, Dr S Tomlinson, Prof J Fallowfield
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Non-Alcoholic Fatty Liver Disease (NAFLD) caused by a high fat diet (HFD) is a growing major public health problem world-wide.
  Precision Medicine DTP – Integration of single-cell RNA sequencing data from human and murine kidney disease to identify novel therapeutic targets
  Research Group: Centre for Cardiovascular Science
  Dr BC Conway, Dr T Chandra, Dr D Ferenbach
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease and for end-stage kidney disease (ESRD), at which point patients require dialysis or transplantation.
  Precision Medicine DTP – Investigating disease causing mutations in PNPase- an approach to understand mitochondrial nucleic acid driven auto-inflammation
  Research Group: Centre of Genomic and Experimental Medicine
  Dr A Dhir, Dr S Tait, Dr T Chandra
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Mitochondrial diseases are a heterogeneous class of disorders often characterized by failure of mitochondrial function and loss of energy associated with respiratory chain complex deficiency.
  Precision Medicine DTP - Modelling Sex Dependent Differences in Human Liver Disease using Stem Cell Derived Models and Organ on a Chip Devices
  Research Group: MRC Centre for Regenerative Medicine
  Dr D Hay, Prof P Saunders
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Metabolic syndrome is a cluster of conditions, which include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels.
  Precision Medicine DTP - Taming the Hippo in mesothelioma through proteogenomics
  Research Group: Centre for Inflammation Research
  Dr C G Hansen, Prof J Lehtio
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Pleural Mesothelioma is an asbestos-related cancer, which originates in the pleural lining of the lung and is characterized by a diverse phenotype.
  Precision Medicine DTP – Using Omics to Understand the Genes and Pathways Underlying Alcohol Use Disorder
  Research Group: Centre of Genomic and Experimental Medicine
  Dr K Evans, Dr T-K Clarke, Dr S Glerup
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Alcohol use disorder (AUD) is a chronic relapsing brain disease characterised by compulsive alcohol use, loss of control over alcohol intake, and a negative emotional state when not using alcohol.
  Precision Medicine DTP - 3D Modeling of Changes in Genome Architecture in Development and Disease
  Research Group: Institute of Cell Biology
  Prof E Schirmer, Dr D Marenduzzo
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Defects in spatial genome organisation have recently been linked to human disease and the National Institutes of Health, USA director speculated that most as yet unidentified disease alleles will occur in non-coding genome regions.
  Precision Medicine DTP – A novel data integration method for cellular social networks within self-organising multicellular systems
  Research Group: Institute of Stem Cell Research
  Dr G Blin, Dr L Schumacher, Dr A Tsanas
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. The quantification and interrogation of how the cells organise and interact with their environment is fundamental for advancing developmental biology, cancer research, pharmaceutics and medical diagnostics.
  Precision Medicine DTP - Connecting Molecular Profiles to Phenotype: A Proteomic Resource for Assigning Cell Cycle and Senescent States
  Research Group: Institute of Cell Biology
  Dr T Ly, Dr A Lindqvist
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. A hallmark of cancer is aberrant cell cycle control leading to pathological cell proliferation. Cell cycle progression is controlled by key kinases, such as cyclin-dependent kinases (CDKs) and polo-like kinases (PLKs).
  Precision Medicine DTP - Defining and predicting the molecular basis for male infertility
  Research Group: Institute of Cell Biology
  Dr J Welburn, Dr J Marsh
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Male infertility is on the rise. While the genetics and molecular mechanisms underlying the phenomenon remain poorly understood, mutations in >75 human protein-coding genes have already been confidently linked to male infertility (Oud et al, 2019).
  Precision Medicine DTP - Dynamic changes that protect oocytes from chromosome mis-segregation
  Research Group: Institute of Cell Biology
  Prof H Ohkura, Dr T Ly, Dr A Kouznetsova
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Before fertilisation, oocytes arrest in metaphase in humans, as well as many other animal species including mouse and Drosophila.
  Precision Medicine DTP - Time-resolved single-cell analysis of neural cell differentiation in motor neuron disease (MND)
  Research Group: Institute of Quantitative Biology, Biochemistry and Biotechnology
  Dr C Sibley, Dr R Grima
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Motor neuron disease (MND) is a relentlessly progressing and devastating condition caused by the selective degeneration of upper and lower motor neurons essential for all movement.
  MRC Precision Medicine DTP: Deep impact – mining the meningococcal metagenome for antimicrobial resistance to provide public health intelligence data
  Research Group: Dental School
  Prof A Smith, Dr C Cameron
Application Deadline: 8 January 2020

Funding Type

PhD Type

Supervisors. Prof Andrew Smith. Dr Claire Cameron. Prof Martin Maiden. Project summary. This project will focus on meningococcal disease which is a severe and potentially fatal infection of the brain and blood stream with highest incidence in teenagers and young children.
  Investigating the diarrhoeal pathogens in vulnerable populations in developing countries
  Dr A Tsaousis, Dr M Shepherd
Application Deadline: 19 January 2020

Funding Type

PhD Type

Project Aim.
  Control and inhibition of virus replication
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A.K Tuplin
Applications accepted all year round

Funding Type

PhD Type


The Tuplin laboratory utilises a range of cutting-edge approaches to investigate how arboviruses - specificaly Chikungunya, Dengue and Zika viruses - control replication and translation of their genomes through interactions between RNA structures, host cell proteins and non-coding RNA, and the potential of such RNA elements/interactions as novel therapeutic targets.
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