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We have 8 Cell Biology (yeast) PhD Projects, Programmes & Scholarships

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Cell Biology (yeast) PhD Projects, Programmes & Scholarships

We have 8 Cell Biology (yeast) PhD Projects, Programmes & Scholarships

Identification of phosphatases that inactivate the endoplasmic reticulum stress sensor Ire1

A self-funded PhD studentship is available in the group of Dr. Martin Schröder in the Department of Biosciences at Durham University to study stress signalling mechanisms originating from the endoplasmic reticulum. Read more

Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Assessment of phototherapy with model organism Saccharomyces cerevisiae

Project Overview.  . Saccharomyces cerevisiae is extensively used as model organism and is well understood from a sequencing perspective so up-regulation or down-regulation of gene expression is tractable. Read more

Cellular mechanisms of equal chromosome segregation and genome stability

The PhD project will investigate how chromosomes segregate equally in each cell division through epigenetic regulation of the centromere, and how cells respond in stress conditions to maintain genome instability. Read more

MSc by Research: Degrade or die: Understanding proteasome regulation upon stress

The Rousseau lab is interested in decoding how protein degradation by the proteasome is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious. Read more

Understanding gene regulation by HDAC1 complexes in development and cancer

Packaging DNA into nucleosomes helps protect the long fragile genomes of eukaryotic species. However, in doing so it becomes an ever-present physical barrier to the machinery required for its replication, repair and transcription. Read more

Targeting ageing and neurodegenerative diseases using the fruit-fly Drosophila melanogaster

In the last 20 years the fruit fly Drosophila melanogaster emerged as a pre-eminent model system for studying changes that occur during both normal and pathological ageing (~75 per cent of the genes that cause disease in humans are also found in the fruit fly!). Read more

Investigating monogenic disorders of the protein synthesis machinery

Translation of mRNA into proteins is a critical cellular biological process. We recently described a novel human disorder, now called Faundes-Banka Syndrome (FABAS), caused by heterozygous variants in EIF5A1 that encodes a translation factor. Read more
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