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The University of Manchester, Faculty of Biology, Medicine and Health Cell Biology / Development PhD Projects, Programs & Scholarships

We have 129 The University of Manchester, Faculty of Biology, Medicine and Health Cell Biology / Development PhD Projects, Programs & Scholarships

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  (BBSRC DTP CASE) Analysing the efficiency of protein secretion using Lattice Lightsheet Microscopy
  Prof V Allan, Prof M Lowe, Prof S Cartmell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein-based biopharmaceuticals are of tremendous importance both for providing disease treatments, and for the UK economy. They are typically manufactured using mammalian host cells, but some are much harder to produce than others.
  (BBSRC DTP CASE) Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting
  Dr J Bella, Dr S Richardson, Dr M Domingos
Application Deadline: 31 January 2020

Funding Type

PhD Type

We are looking for an enthusiastic and talented graduate from a relevant biomedical or materials science degree to develop next-generation, sustainable collagen-based scaffolds for stem cell culture, differentiation, and 3D bioprinting, aimed at tissue regeneration applications.
  (BBSRC DTP) A moving account of degradation: receptor signalling, endosomes and motor proteins
  Prof P Woodman, Prof V Allan, Prof M Lowe
Application Deadline: 31 January 2020

Funding Type

PhD Type

Endosomes are hubs for regulating multiple signaling pathways, because endosomal sorting determines the fate of cell surface signalling receptors.
  (BBSRC DTP) Complexity of heart development arising from evolution of signalling systems
  Dr K Hentges, Dr D Talavera, Prof S Lovell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein families grow or shrink in size during evolution due to gene duplication and gene loss events. These events provide opportunities for protein function specialisation or innovation.
  (BBSRC DTP) Cytoskeletal re-arrangements leading to correct neuron polarisation during vertebrate CNS development
  Dr R Das, Prof V Allan, Dr S Herbert
Application Deadline: 31 January 2020

Funding Type

PhD Type

Background. Neuronal differentiation during embryonic development is a fundamentally important process that ultimately results in the formation of functional neural circuitry.
  (BBSRC DTP) Definition of integrin signalling networks in neurons in vivo
  Prof A Prokop, Prof M J Humphries
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cell adhesion molecules (CAMs) of the plasma membrane physically tie cells together into tissues, both via interaction of cells with other cells or with ECM (extracellular matrix); they also constitute hubs of information exchange with neighbouring cells and the environment.
  (BBSRC DTP) Definition of the force-sensitive mechanisms linking the plasma membrane to the nucleus using proximity biotinylation-based proteomics
  Prof M J Humphries, Dr J Swift
Application Deadline: 31 January 2020

Funding Type

PhD Type

The behaviour of cells is determined by how they interpret their genetic and epigenetic programming in the context of signals from their surroundings.
  (BBSRC DTP) Developing a whipworm vaccine composed of virus-like particles expressing Trichuris T cell epitopes
  Prof K Else, Prof J P Derrick
Application Deadline: 31 January 2020

Funding Type

PhD Type

Vaccination is one of the greatest advances in global health; however most successful vaccines have been made empirically. We still have little insight into how many vaccines work and the mechanisms by which they trigger protective immune responses.
  (BBSRC DTP) Epigenetic mechanisms of behavioural, placental and cognitive impairment in a neurodevelopmental model for schizophrenia
  Dr R Hager, Prof J Neill, Dr J Glazier
Application Deadline: 31 January 2020

Funding Type

PhD Type

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016).
  (BBSRC DTP) Exploiting transcriptional regulation to improve plant cell wall as a feedstock for the sustainable production of biofuels and other chemicals
  Prof S Turner, Dr M Kim, Prof A Sharrocks
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cellulose is a polymer of glucose and its remarkable structural properties means it is the world’s most abundant biopolymer. Cellulose from higher plants is an abundant source of renewable material that can be used as a source of raw material for chemical and fuel production, or for generating novel biomaterials.
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