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University of Leeds, Faculty of Medicine and Health Cell Biology / Development PhD Projects, Programs & Scholarships

We have 15 University of Leeds, Faculty of Medicine and Health Cell Biology / Development PhD Projects, Programs & Scholarships

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Showing 11 to 15 of 15
  Oncogenic mechanisms causing malignant transformation of lymphoid cells
  Prof U Klein
Applications accepted all year round

Funding Type

PhD Type

Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  The use of CRISPR-Cas gene editing for functional characterisation of genetic variants associated with malignant hyperthermia susceptibility
  Prof P Hopkins, Dr M Shaw
Application Deadline: 17 March 2020

Funding Type

PhD Type

Background. Malignant hyperthermia (MH) is a potentially fatal hypermetabolic reaction affecting genetically susceptible individuals exposed to inhalational anaesthetics.
  Using massively-paralleled sequencing to find the cause of inherited conditions that affect the front of the eye
  Dr M Ali, Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Eye diseases are a common cause of human disability and many of them are inherited. These include congenital as well as adult-onset conditions and diseases of ageing, and may involve abnormalities at the back of the eye or the anterior eye structures.
  Using next-generation sequencing and CRISPR-Cas9 gene editing to investigate penetrance and phenotypic variation in inherited eye disease
  Dr C Toomes
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal diseases (IRDs) result from mutations in over 250 different genes, many of them implicated by the Leeds Vision Research Group (eg Panagiotou et al 2017, AJHG 100:960-968; El-Asrag et al 2015, 96:948-54).
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