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We have 22 University of Leeds Cell Biology PhD Projects, Programmes & Scholarships

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University of Leeds Cell Biology PhD Projects, Programmes & Scholarships

We have 22 University of Leeds Cell Biology PhD Projects, Programmes & Scholarships

University of Leeds

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NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

University of Leeds Faculty of Medicine and Health
Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more
 Supervisors: Dr R Ariens, Prof D J Beech, Dr E Levelt
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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NIHR Leeds BRC: An interferon diagnostic to inform early detection and prevention strategies in Ana positive CTDs

University of Leeds Faculty of Medicine and Health
Type I interferons (IFN) play a role in a wide range of rheumatic and musculoskeletal diseases (RMDs), and strong evidence suggests that measurement of IFN activity could have clinical value, although testing has not progressed into clinical settings. Read more
 Supervisors: Dr F Del Galdo, Dr R Ross
 26 May 2024  PhD Research Project  Competition Funded PhD Project (UK Students Only)
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Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health
Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more
 Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health
The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more
 Supervisors: Dr G Mavria, Dr S Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health
Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more
 Supervisor: Dr P Laslo
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Oncology: Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids

University of Leeds Faculty of Medicine and Health
Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. Read more
 Supervisors: Dr I Knot, Prof D Jayne
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health
Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more
 Supervisors: Dr MA Volpato, Prof M Hull
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health
Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more
 Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

University of Leeds Faculty of Medicine and Health
Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more
 Supervisors: Dr F Errington-Mais, Dr V Jennings
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Genetics: Unravelling the Norrin/beta-catenin signaling pathway and its role in retinal angiogenesis and blindness

University of Leeds Faculty of Medicine and Health
Our previous work on the genetic analysis of individuals with the inherited retinal disease Familial Exudative Vitreoretinopathy (FEVR), has helped identify a new angiogenesis pathway, the Norrin/beta-catenin pathway. Read more
 Supervisors: Dr C Toomes, Dr J Bond, Dr S Bell
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Cancer: Complex 3D modelling of the tumour microenvironment for immunotherapy combination screening

University of Leeds Faculty of Medicine and Health
Cancer immunotherapy holds significant promise for the treatment of a range of cancers. Read more
 Supervisors: Dr MA Volpato, Dr F Errington-Mais
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Haematology: Oncogenic mechanisms causing malignant transformation of B cells and plasma cells

University of Leeds Faculty of Medicine and Health
Cancers of B cells and plasma cells, lymphomas and multiple myeloma, can be very aggressive, and often the cancer rapidly reoccurs after standard therapy. Read more
 Supervisor: Prof U Klein
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Virology: Unique Antiviral Therapy targeting Zika and Related Viruses

University of Leeds Faculty of Medicine and Health
Zika Virus (ZIKV) has emerged as a new mosquito-borne threat to public health after the devastating South American outbreak. Read more
 Supervisors: Dr S Griffin, Dr A Kalli, Dr C McKimmie
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Virology: Sun exposure as a novel risk factor for Zika virus infection

University of Leeds Faculty of Medicine and Health
Mosquito-borne disease is now receiving unprecedented attention due to major outbreaks in new geographic areas including Brazil, Mexico, India, China, the Middle East and SE Asia. Read more
 Supervisors: Dr C McKimmie, Dr K Shams, Dr S Griffin
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Immunotherapy: Manipulating T cell metabolism to improve anti-tumour immunity

University of Leeds Faculty of Medicine and Health
The induction of immune responses to tumours can provide long-lasting protection from cancer. In this regard, T cells can suppress tumour growth by directly killing cancer cells and by producing inflammatory cytokines. Read more
 Supervisors: Dr M Lorger, Dr R Salmond
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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