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University of Leicester, Molecular and Cell Biology Cell Biology / Development PhD Projects, Programs & Scholarships

We have 19 University of Leicester, Molecular and Cell Biology Cell Biology / Development PhD Projects, Programs & Scholarships

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Showing 1 to 15 of 19
  Characterising the function of PRPF40 in spliceosome assembly at the single molecule level
  Dr O V Makarova, Prof I C Eperon
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. Most of genes in eukaryotes contain introns that are recognised and spliced out by a macromolecular complex, the spliceosome.
  Control of gene expression by RNA-binding proteins
  Prof I C Eperon
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. RNA-binding proteins regulate the selection of splice sites in RNA.
  Cryo-Electron Microscopy of Histone Deacetylase Complexes
  Prof J Schwabe, Dr S Cowley
Application Deadline: 12 January 2020

Funding Type

PhD Type

Histone deacetylase complexes play a role in many cellular processes, such as cancer, cell cycle progression and DNA repair. Investigating how these HDAC complexes act to control gene expression and their interactions with other proteins should lead to an understanding of their influence in the cell.
  Defining how reactive small molecules in cells regulate the oncogenic KRAS.G12C GTPase
  Dr R Hopkinson, Dr K Tanaka
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. The KRAS gene are among the most mutated genes in cancer cells. KRAS.G12C (glycine at position 12 to cysteine), which is found in about 12% of all KRAS-mutated cancers, has attracted much attention as the cysteine residue is highly reactive.
  Enzyme mechanism through advanced techniques
  Dr P C E Moody
Applications accepted all year round

Funding Type

PhD Type

This studentship is for up to 4 years and supported by a Royal Society Wolfson Fellowship. “Traditional” protein X-ray crystallography has contributed enormously to our understanding of enzyme mechanisms.
  Epigenetic signalling mechanisms of SET domain proteins
  Dr T Schalch, Dr C Dominguez
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. SET domain proteins are named after a shared motif in the Drosophila proteins Su(var)3-9, Enhancer-of-zeste and Trithorax, and they form a major branch of the protein lysine methyltransferase enzymes.
  Investigation into the mitochondrial connection in protection against cardiovascular disease
  Dr N Storey, Dr K Herbert
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. Ischaemia damages heart muscle and reperfusion of blood flow is vital for restoring function. Paradoxically, reperfusion itself can cause further irreversible tissue damage.
  Modulation of cell fate decisions to define novel cancer therapies
  Dr S Macip, Dr J Fox
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. Whether a cell dies or not has profound consequences on health. For instance, if programmed cell death (apoptosis) is not correctly executed in response to damage signals it can lead to cancer.
  Molecular Modelling of P2X receptor agonism and antagonism
  Dr R Schmid
Application Deadline: 12 January 2020

Funding Type

PhD Type

P2X receptors (P2XRs) form a family of ligand-gated ion channels activated upon binding of extracellular ATP (for review see [1]).
  Obtaining mechanistic insights into interplay of multiple effectors of oncogenic RAS molecules
  Dr K Tanaka, Dr A Revyakin
Application Deadline: 12 January 2020

Funding Type

PhD Type

The RAS family of small GTPases act as signalling hubs regulating cell proliferation and differentiation. Importantly, about 20% of all human cancers harbour mutations in RAS genes (COSMIC).
  Protein condensates and phase separation: Understanding of molecular mechanism of microtubule anchoring
  Dr K Tanaka, Dr A Revyakin
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. Microtubule (MT) steers a wide range of fundamental cellular activities by firmly anchoring at the centrosome, which consists of a pair of centrioles and surrounding pericentriolar material (PCM).
  Revealing molecular mechanisms of gene silencing
  Dr T Schalch, Dr S Cowley
Application Deadline: 12 January 2020

Funding Type

PhD Type

Regulation of transcription through chromatin architecture is governed by nucleosome remodelers and chromatin modifying complexes.
  Structural Characterization of the Interleukin-17AA, FF and AF/Receptor Complexes: Insights into the Cooperativity and Assembly of the Heterotrimeric Signalling Complex
  Prof M D Carr, Dr L Waters, Dr G Hall
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. The proinflammatory cytokines IL17A, IL17F and IL17AF have been shown to signal via heterotrimeric signalling complexes formed with their receptors.
  Structural investigations to reveal how splicing factors cooperate or compete for pre-mRNA binding?
  Dr C Dominguez, Prof I C Eperon
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. Alternative RNA splicing is an essential process leading to multiple protein isoforms from a single gene.
  Structural mechanism of signal-dependent gene transcription
  Prof D Panne, Dr A Revyakin
Application Deadline: 6 January 2020

Funding Type

PhD Type

PhD Start date. September 2020. The control of gene transcription is the main regulatory step for cellular gene regulation.
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