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Cell Biology / Development PhD Projects, Programs & Scholarships

We have 505 Cell Biology / Development PhD Projects, Programs & Scholarships

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We have 505 Cell Biology / Development PhD Projects, Programs & Scholarships

Insights into eye disease: understanding the molecular basis of age-related macular degeneration

Dysregulation of innate immunity has been implicated as playing a key role in the development of age-related macular degeneration (AMD) – a major form of blindness in the industrialised world (see [1-5]). Read more

The role mRNA-specific translation during chronological aging

Biological ageing can be thought of as a progressive decline in the ability of an organism to survive stress and disease. It is a complex process which is influenced by both genetic and environmental factors. Read more

Understanding the gene regulatory landscape of embryonic stem cells and cancer cells

Cell identity is ultimately determined through decoding the genome through the action of gene regulatory mechanisms. In particular, sculpting of the chromatin landscape to reveal unique configurations of gene regulatory elements in each cell type is a major driver of cell identity. Read more

Proteomics to determine how defects in membrane trafficking within the secretory pathway cause human disease

Work in the Lowe laboratory is aimed at deciphering the molecular mechanisms that control membrane trafficking within cells. A major focus of our work is the trafficking of proteins to and through the Golgi apparatus, which lies at the heart of the secretory pathway. Read more

Identifying novel therapeutic targets in CMML

Chronic myelomonocytic leukaemia (CMML) is a clonal stem cell neoplasm defined by abnormal monocytosis and dysplasia. A quarter of CMML patients progress to acute myeloid leukaemia and these patients have dismal prognosis. Read more

Defining the physiological role and regulation of biological methylations

The regulation of gene expression and function operates at multiple levels. Metabolic pathways in the cell generate metabolites that directly affect DNA, RNA and proteins, regulating the expression and function of many genes, often feeding back on the very enzymes that catalysed their synthesis. Read more

Uncovering the molecular mechanisms underlying spinal cord regeneration

About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have very poor capacities to regenerate, thus resulting in a permanent loss of function. Read more

Rhythmic control of energy balance - to understand how our internal clocks regulate energy metabolism

24-hour rhythms are present in virtually all aspects of our behaviour and physiology. These rhythms are underpinned by circadian clocks that run throughout the body, and act within each tissue to orchestrate many organ functions and rhythmic activities (e.g. Read more

Mechanistic analysis of neurodevelopmental disorders caused by mutations in the gene RAC1

RAC1 is a signalling protein that regulates many cellular processes and is essential during embryonic development. We recently discovered a novel genetic disease called RAC1-related neurodevelopmental disorder (RRND) that results from mutations in the RAC1 gene. Read more

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