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Cell Biology PhD Projects, Programmes & Scholarships
We have 501 Cell Biology PhD Projects, Programmes & Scholarships
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A biologic drug blocking ROR2 for disease modification in osteoarthritis
We reported that silencing the WNT receptor ROR2 results in protection from cartilage breakdown and rapid pain relief in a murine model of osteoarthritis and in chondrogenesis in vitro and in vivo with human osteoarthritic chondrocytes (Thorup et al. Read more
Mathematical modelling of herpes simplex virus transmission in 2- and 3- dimensions
This is an exciting opportunity to undertake an EPSRC-funded PhD that will combine experimental work with mathematical modelling to describe the transmission of the human pathogen herpes simplex virus (HSV) in human cells and tissue models, and develop a comprehensive tool for assessing the parameters that influence virus transmission. Read more
Regulation of apoptosis-induced compensatory cell proliferation and its implications for cancer and tissue regeneration
In multi-cellular organisms, coordinated cell death (e.g. apoptosis) and cell replacement is critical for tissue recovery in response to stress or damage. Read more
Development and use of advanced optical microscopy to facilitate gene delivery and gene therapy in 3D cardiac disease models
This PhD studentship aims to develop and use a novel optical technique for microscopic imaging and single-cell transfection for cells in 3D cardiovascular models. Read more
Next-generation mass spectrometry diagnostics to guide patient management post-SARS-CoV-2 infection
Applications will be reviewed until a suitable candidate is appointed. The COVID-19 pandemic continues to contribute to extensive morbidity and mortality worldwide. Read more
Harnessing extracellular biomechanics to engineer young and prematurely aged skin models in vitro
Background. Skin tissue contains biomechanically, biochemically and topologically distinct niches for its resident cells. Read more
Novel anti-pathogen regulatory mechanisms driven by Human Guanylate Binding Proteins
Human GBPs are a family of seven ~65kDa GTPases whose expression is upregulated by IFNg, for example during an infection. All mammalian GBPs contain a GTPase domain and a C-terminal helical region. Read more
mRNA epigenetics: Charaterization of a novel layer of gene regulation for essential brain functions
Research Group:
BBSRC MIBTP
For over 40 years we know about modified nucleotides in mRNA, but the functions for these essential modifications are largely elusive. Read more
Molecular genetic characterization of Drosophila reproductive behaviours for exploitation in insect population control
Research Group:
BBSRC MIBTP
Female reproductive behaviours in most insects profoundly change after mating leading to rejection of courting males and induction of egg laying. Read more
Epitranscriptomic mechanisms in the maternal to zygotic transition of vertebrate embryos
Research Group:
BBSRC MIBTP
Most mRNAs contain modified nucleotides in mRNA, but we know very little about their function (Haussmann et al, 2016, Dezi et al, 2016, Roignant and Soller, 2017). Read more
Determining novel molecular regulators of necrosis controlling premature cell death
Necrosis, a form of premature cell death, is frequently caused by excessive insults such as trauma, infection and toxins. It has been implicated in many human diseases including cancer, neurodegenerative disorders and inflammatory diseases. Read more
Coordination between RNAPII transcription and DNA replication
RNA Pol II (RNAPII) transcription and DNA replication are the two essential-for-life processes that use as a substrate the DNA in our cells, allowing the¬¬m to express the content of their genetic information and to propagate these instructions to daughter cells. Read more
Cell-type dependent pharmacological regulation of cellular mitophagy for therapeutic application in Parkinson’s disease
The cellular quality-control process of mitophagy, entailing selective degradation of defective mitochondria (following damage to their DNA) by the process of autophagy, has attracted considerable research interest. Read more
Cell models to investigate mechanisms of disease; the role of redox in neurodevelopment and neurodegeneration
We use cell models of neurodevelopment and neurodegeneration to study the mechanisms that underpin diseases like schizophrenia and dementia. Read more
BBSRC MIBTP - Identification of pathways deregulating neuronal ELAV/Hu RNA binding proteins and alternative splicing in neurodegeneration
Research Group:
BBSRC MIBTP
ELAV/Hu proteins comprise a family of highly conserved neuronal RNA binding proteins important for the development of the nervous system and for neuronal functions. Read more