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Cell Biology PhD Projects, Programmes & Scholarships

We have 419 Cell Biology PhD Projects, Programmes & Scholarships

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We have 419 Cell Biology PhD Projects, Programmes & Scholarships

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Identifying novel regulators of haematopoiesis using flies

Supervisors. Iwan Evans (primary supervisor); Steve Brown (Biosciences, secondary supervisor). Project details. Control of blood cell proliferation, survival and activation is critical to the health of an organism. Read more

Meals for macrophages – investigating how macrophages engulf and process dying cells in vivo

Supervisors. Iwan Evans (primary supervisor); Phil Elks and Simon Johnston (secondary supervisors). Project details. A critical role for phagocytic cells such as macrophages is the engulfment and subsequent degradation of dying cells and debris. Read more

Investigating the control and function of macrophage subtypes using Drosophila melanogaster

Supervisor(s). Iwan Evans (Primary Supervisor, IICD) and Martin Zeidler (Second Supervisor, Biosciences). Project details. The phagocytic white blood cells known as macrophages are a highly heterogeneous population of cells. Read more

Disruption of nuclear envelope regulation of miRNA, enhancer, and gene loci positioning leads to aberrant development and disease

  Research Group: Institute of Cell Biology
Defects in spatial genome organisation are linked to human disease and it is speculated that most as yet unidentified disease alleles will occur in non-coding genome regions. Read more

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Regulation and mechanics in polarity

Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more

Is there a Role for Activated Akt in Palatogenesis?

Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more

Development of micro-incubator OCT/ OCE bioreactor system to engineer a robust musculoskeletal tissue model

Achieving adequate musculoskeletal tissue healing is one of the most challenging factors in the repair of orthopaedic tissues. The problem of hard-to-soft tissue fixation is the major cause of failure of replacement grafts and leads to further musculoskeletal degeneration e.g. Read more

Interdisciplinary investigation of a large effect of sulfasalazine on HbA1c

The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1]. Read more

Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in human cells

There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD) but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. Read more

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