Continue with FacebookLooking to list your PhD opportunities? Log in here.
Cell Biology PhD Projects, Programmes & Scholarships
We have 419 Cell Biology PhD Projects, Programmes & Scholarships
PhD saved successfully
Identifying novel regulators of haematopoiesis using flies
Supervisors. Iwan Evans (primary supervisor); Steve Brown (Biosciences, secondary supervisor). Project details. Control of blood cell proliferation, survival and activation is critical to the health of an organism. Read more
Meals for macrophages – investigating how macrophages engulf and process dying cells in vivo
Supervisors. Iwan Evans (primary supervisor); Phil Elks and Simon Johnston (secondary supervisors). Project details. A critical role for phagocytic cells such as macrophages is the engulfment and subsequent degradation of dying cells and debris. Read more
Investigating the control and function of macrophage subtypes using Drosophila melanogaster
Supervisor(s). Iwan Evans (Primary Supervisor, IICD) and Martin Zeidler (Second Supervisor, Biosciences). Project details. The phagocytic white blood cells known as macrophages are a highly heterogeneous population of cells. Read more
The interplay between ethnicity, the microbiome and DNA damage in prostate cancer
In the UK, black men are at greater risk of prostate cancer and have a higher mortality rate compared to Caucasian and Asian men. Read more
Disruption of nuclear envelope regulation of miRNA, enhancer, and gene loci positioning leads to aberrant development and disease
Research Group:
Institute of Cell Biology
Defects in spatial genome organisation are linked to human disease and it is speculated that most as yet unidentified disease alleles will occur in non-coding genome regions. Read more
Elucidating the mechanisms of pathology in neurodevelopmental white matter diseases
Our research interests are to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model. Read more
Preclinical validation of NUDT22 as target in lung cancer
We previously identified NUDT22 as an UDP-glucose hydrolase and an important new player in nucleotide and energy metabolism. Read more
Identification of novel combination therapies exploiting nucleotide metabolism and DNA repair to treat cancer
Nucleotide analogues (antimetabolites) are used as anti-cancer treatments in the clinic for many decades, most commonly for the treatment of haematological, breast, ovarian and intestinal cancers. Read more
Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation
Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more
Regulation and mechanics in polarity
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
Is there a Role for Activated Akt in Palatogenesis?
Main Aim. The project will use a medial edge epithelial (MEE) cell line as an in vitro model. These cells will be used to investigate the effects of exogenous TGFβ-3 and activation of Akt on cell migration, epithelial to mesenchymal transition (EMT) and apoptosis. Read more
Development of micro-incubator OCT/ OCE bioreactor system to engineer a robust musculoskeletal tissue model
Achieving adequate musculoskeletal tissue healing is one of the most challenging factors in the repair of orthopaedic tissues. The problem of hard-to-soft tissue fixation is the major cause of failure of replacement grafts and leads to further musculoskeletal degeneration e.g. Read more
Interdisciplinary investigation of a large effect of sulfasalazine on HbA1c
The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1]. Read more
Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in human cells
There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD) but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD. Read more
Validation of test strategies for the identification of adverse effects of chemicals on the human fetal ovarian development
The European FREIA project. , which both supervisors are part of, is specifically designed to address how female reproductive health can be safeguarded from endocrine disrupting chemicals (EDCs). Read more