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We have 28 Toxicology (drug) PhD Projects, Programmes & Scholarships

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Toxicology (drug) PhD Projects, Programmes & Scholarships

We have 28 Toxicology (drug) PhD Projects, Programmes & Scholarships

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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more
 Supervisors: Dr S Shnyder, Dr S Kantamneni
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Pharmacovigilance and Polypharmacology: Identification of differential side effects within drug classes and links to their unique modes of action

University of Birmingham School of Pharmacy
The aim of this study is to determine the differences and potential mechanistic rationale for observed adverse drug reactions (ADRs) in a series of related drug classes. Read more
 Supervisor: Dr M Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Crystal engineering new, more effective medicines.

Newcastle University School of Pharmacy
BACKGROUND. Neglected Tropical Diseases (NTDs) – a diverse group of infectious diseases – continue to thrive across low- income populations. Read more
 Supervisor: Dr O Kavanagh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Drug metabolism - prediction, detection, and isolation

University of Birmingham School of Pharmacy
Electrosynthesis (ES) is a green methodology for preparing and interpreting drug metabolites linked to toxicology. ES describes the synthesis of chemical compounds in an electrochemical cell. Read more
 Supervisor: Dr M Jones
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Quantifying the risk of precipitating drug induced crystalluria (XTALURIA)

Newcastle University School of Pharmacy
The growth of crystals in the body often results in pain, damage, and gross harm. Read more
 Supervisor: Dr O Kavanagh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of protease-activated anti-cancer prodrugs

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
 Supervisors: Prof R Falconer, Prof P Loadman
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Crystal engineering new, more effective medicines.

Newcastle University Faculty of Medical Sciences Graduate School
RESEARCH PROJECT. To uncover pharmaceutical problems, our team collaborates with a wide range of disciplines, including pharmacists, pharmaceutical scientists, chemists and engineers at internationally renowned pharmacy departments and at multinational pharmaceutical companies. Read more
 Supervisor: Dr O Kavanagh
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Discovery and profiling of small-molecule inhibitors of cellular nuclease enzymes

University of Nottingham School of Pharmacy
Nuclease enzymes are non-traditional drug targets that attract an increasing amount of interest as potential targets relevant for a variety of therapeutic areas including infection, cancer and bone disease. Read more
 Supervisor: Dr G S Winkler
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Analysing the role of statins in cardiovascular protection

University of Liverpool Department of Pharmacology and Therapeutics
Drug-induced cardiovascular toxicity is a major problem affecting a number of cancer chemotherapy drugs (Cross et al., 2015). Read more
 Supervisors: Dr M Cross, Dr B Wilm, Dr AM Mondru
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Therapeutic resolution of coronavirus (COVID-19) diseases by natural products

University of Bradford Faculty of Life Sciences
  Research Group: Pharmacology and Experimental Therapeutics
Coronavirus now labelled as Covid-19 has become a global pandemic affecting around 200 countries. Currently neither any cure nor any vaccine for Covid-19 has been established. Read more
 Supervisor: Dr T Nasim
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Testing the translational power of zebrafish for studying human heart failure. Ref: 5101

University of Exeter BBSRC South West Doctoral Training Partnership
Supervisors. Dr Matthew Winter, University of Exeter. Dr Yosuke Ono, University of Exeter. Location. Biosciences, Streatham Campus, Exeter. Read more
 Supervisors: Dr M Winter, Dr YO Ono
 22 May 2024  PhD Research Project  Funded PhD Project (UK Students Only)
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Polysialyltransferases as a target in metastatic cancer

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents

University of Bradford Faculty of Life Sciences
  Research Group: Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
 Supervisors: Prof R Falconer, Dr S Shnyder
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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Personalising cancer treatment with tumour evolution modelling using AI-based genomics biomarkers and PK/PD

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Tumour heterogeneity is a major problem limiting the efficacy of targeted oncological therapies. Most advanced tumours eventually become resistant to the treatments, ultimately making the patient succumb to metastatic disease. Read more
 Supervisor: Dr T You
 1 August 2024  PhD Research Project  Self-Funded PhD Students Only
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Molecular characterisation of a novel transporter for the atypical antipsychotic clozapine

University of Liverpool Institute of Systems, Molecular and Integrative Biology
Schizophrenia is a severe psychiatric illness affecting about 24 million people worldwide. Schizophrenia can have a devastating effect on a patient’s life and is associated with increased mortality, with life expectancy reduced on average by 15 years compared to that of the general population. Read more
 Supervisors: Dr D Dickens, Prof M Pirmohamed
 Year round applications  PhD Research Project  Self-Funded PhD Students Only
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