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Chemical Sciences PhD Projects, Programs & Scholarships in Czech Republic

We have 14 Chemical Sciences PhD Projects, Programs & Scholarships in Czech Republic

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  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 31 October 2019

Funding Type

PhD Type

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 31 October 2019

Funding Type

PhD Type

The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Dynamics of the Structure Maintenance of Chromosome (SMC) complexes
  Prof J Palecek
Application Deadline: 31 October 2019

Funding Type

PhD Type

The SMC (Structure Maintenance of Chromosome) complexes are the key components of higher-order chromatin fibers and play important roles in genome stability.
  Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression
  Dr D Blažek, Assoc Prof Z Zdráhal, Dr P Alexiou
Application Deadline: 31 October 2019

Funding Type

PhD Type

CDK11 is ubiquitously expressed in all tissues and the CDK11 null mouse is lethal at an early stage of development indicating an important role for Cdk11 in the adult as well as during development.
  Integrative structural biology of 3’UTRs
  Dr P J Lukavsky, Dr B Tichý, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

The non-coding part of the genome vastly increased from worm to humans while the number of protein-coding genes remained constant.
  Investigating the regulation of the RNA modifying enzyme ADAR1 and how it regulates other biological pathways and diseases
  Dr M O'Connell, Dr L Keegan, Dr JN Nováček
Application Deadline: 31 October 2019

Funding Type

PhD Type

The ADAR enzymes convert adenosine into inosine in dsRNA. Inosine is one of the most abundant and best studied modifications found in different classes of RNA.
  Mass spectrometric imaging of biological tissues
  Prof J Preisler, Ms M Machalkova
Application Deadline: 31 October 2019

Funding Type

PhD Type

Mass spectrometry imaging (MSI) exploits the ability of mass spectrometry to identify molecules according to their specific mass and image their distribution across the sample.
  Microenvironmental interactions and regulation of their crosstalk in malignant B-cells by transcription factors
  Prof M Mráz
Application Deadline: 31 October 2019

Funding Type

PhD Type

We are looking for a motivated PhD student that would like to work on the following project funded by the ERC (European Research Council) Starting grant.
  Protein sensitivity of membrane curvature
  Prof R Vácha
Application Deadline: 31 October 2019

Funding Type

PhD Type

The control of biological membrane shape and composition is vital to eukaryotic life. The shape is so specific that it allows us to recognize various organelles in the cell.
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