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Structural Biology PhD Projects, Programs & Scholarships in Czech Republic

We have 11 Structural Biology PhD Projects, Programs & Scholarships in Czech Republic

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Showing 1 to 10 of 11
  A structural basis for the cross-talk between histones and RNA Polymerase II
  Prof R Stefl, Dr K Kubicek, Prof S Vanacova
Application Deadline: 31 October 2019

Funding Type

PhD Type

Chromatin is a highly flexible architecture in which spatially and temporally coordinated changes between structurally condensed states (transcriptionally repressive), and structurally accessible states (transcriptionally active) regulate gene expression.
  Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis
  Dr D Blažek, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

Cdk12 is transcriptional cyclin-dependent kinase (Cdk) found mutated in various cancers. In previous studies we found that Cdk12 maintains genome stability via optimal transcription of key homologous recombination repair pathway genes including BRCA1.
  Cracking the CTD code
  Prof R Stefl, Dr K Kubicek, Dr P Plevka
Application Deadline: 31 October 2019

Funding Type

PhD Type

The concept of the CTD code that specifies the position of RNAPII in the transcriptional cycle and thus recruits specific processing factors, was suggested almost a decade ago.
  Dynamics of the Structure Maintenance of Chromosome (SMC) complexes
  Prof J Palecek
Application Deadline: 31 October 2019

Funding Type

PhD Type

The SMC (Structure Maintenance of Chromosome) complexes are the key components of higher-order chromatin fibers and play important roles in genome stability.
  Integrative structural biology of 3’UTRs
  Dr P J Lukavsky, Dr B Tichý, Prof Z Zdrahal
Application Deadline: 31 October 2019

Funding Type

PhD Type

The non-coding part of the genome vastly increased from worm to humans while the number of protein-coding genes remained constant.
  Mass spectrometric imaging of biological tissues
  Prof J Preisler, Ms M Machalkova
Application Deadline: 31 October 2019

Funding Type

PhD Type

Mass spectrometry imaging (MSI) exploits the ability of mass spectrometry to identify molecules according to their specific mass and image their distribution across the sample.
  Protein sensitivity of membrane curvature
  Prof R Vácha
Application Deadline: 31 October 2019

Funding Type

PhD Type

The control of biological membrane shape and composition is vital to eukaryotic life. The shape is so specific that it allows us to recognize various organelles in the cell.
  Regulation of protein-protein interactions
  Prof R Vácha
Application Deadline: 31 October 2019

Funding Type

PhD Type

The project is focused on the regulation of protein interactions, which have been associated with numerous diseases including cancer.
  Structural and time-resolved studies of phage replication in bacterial biofilm
  Dr P Plevka
Application Deadline: 31 October 2019

Funding Type

PhD Type

When Staphylococcus aureus cells form a biofilm in the human body they become shielded from the immune system and highly resistant to antibiotics.
  Structural studies of the TPLATE complex
  Dr K Tripsianes
Application Deadline: 31 October 2019

Funding Type

PhD Type

The TPLATE complex (TPC) is essential for endocytosis in plants, yet it is evolutionary lost from yeasts and animals, pointing to the fact that endocytosis is mechanistically regulated differently.
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