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University of Sheffield, School of Biosciences PhD Projects, Programmes & Scholarships

We have 20 University of Sheffield, School of Biosciences PhD Projects, Programmes & Scholarships

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School of Biosciences  University of Sheffield

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We have 20 University of Sheffield, School of Biosciences PhD Projects, Programmes & Scholarships

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The causes of speciation rate variation in nature

The project. Rates of species formation vary dramatically across the tree of life and contribute to profound differences in species richness among clades, regions and through time. Read more

Investigating the Roles for deSUMOylation Enzyme SENP3 in Autophagy Impaired by α-synuclein

Aggregation of α-synuclein protein in neuronal cells has been strongly implicated in the pathogenesis of neurodegenerative disorders (Synucleinopathies) including Parkinson's disease and dementia with Lewy bodies. Read more

Cell/extracellular matrix interaction during cell cycle progression: a novel role in controlling nucleotide metabolism?

The deregulation of cell cycle progression is a common feature of cancer formation and progression. Cell/extracellular matrix (ECM) interaction is widely known to support the progression of the cells through the cell cycle. Read more

Cancer cells ‘feed’ on extracellular matrix components under starvation conditions: how can they do it?

Background. The tumour microenvironment (TME) has a key role in promoting tumour formation and progression. In breast and pancreatic cancers, this accompanied by the accumulation of extracellular matrix (ECM) in the TME. Read more

Obtaining a molecular understanding of antibody secretion

Plasma cells are the antibody producing cells of the immune system so are vital for fighting infection. Plasma cells secrete hundreds of millions of antibody molecules per day and this is achieved by a dramatic upregulation of their biosynthetic pathway. Read more

Exploring evolutionary change through genomic sequencing of museum specimens

Next-generation sequencing has made it possible to sequence the genomes of museum specimens dating back several hundred years. In this project you will generate genomic data from museum specimens of birds, principally great tits. Read more

Environmental regulation of crop productivity

Crop productivity is highly dependent on environmental conditions. Understanding the mechanisms by which plants respond to environmental signals will therefore allow us to select for climate resilient crops and improve global food security. Read more

How does paclitaxel kill cells and why do some cells evade it?

Paclitaxel (Taxol) is a microtubule-stabilizing drug widely used for the treatment of breast, ovarian and lung cancers. For many years, it was thought to kill cancer cells by inducing mitotic arrest, thus preventing proliferation. Read more

Role of primary cilia in skeletal muscle stem cells and muscle regeneration.

Primary cilia are cellular organelles present at the surface of many cell types in vertebrates. In recent years, they have been shown to play essential roles in relaying signalling information from the environment to the cell. Read more

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