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The University of Manchester, Department of Chemistry PhD Projects, Programs & Scholarships

We have 18 The University of Manchester, Department of Chemistry PhD Projects, Programs & Scholarships

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  A bioinformatics approach to understanding protein solubility tags
  Dr J Warwicker, Dr R Curtis
Applications accepted all year round

Funding Type

PhD Type

The crowded environment of a cell cytoplasm reveals that proteins and other biological molecules co-exist at high macromolecular concentrations.
  A step change in the modelling of enzymatic catalysis
  Prof P Popelier, Dr L Johannissen
Applications accepted all year round

Funding Type

PhD Type

A deep understanding of enzymatic processes requires an atomic-level description, which is often beyond experimental techniques but achievable through synergy with computational chemistry.
  Accurate energy evaluation of receptor-ligand interaction
  Prof P Popelier, Dr S De Visser
Applications accepted all year round

Funding Type

PhD Type

Drug design routinely uses existing computational methods to evaluate the interaction energy between receptor (protein) and ligand (drug) in molecular docking.
  Characterising surface properties of protein biopharmaceutical molecules
  Dr A Golovanov, Dr J Warwicker
Applications accepted all year round

Funding Type

PhD Type

Protein biologicals have great potential for the effective treatment of a wide range of diseases. However, aggregation and instability are inherent issues with all protein pharmaceuticals, which is a problem that can limit their utility and developability.
  Control of antibiotic production through synthetic biology of bacterial hormone signalling
  Prof E Takano, Prof R Breitling
Applications accepted all year round

Funding Type

PhD Type

There is an urgent need for new antibiotics due to an increase in antibiotic resistance. To produce these essential drugs efficiently in biotechnological systems, we need to have a better understanding of the regulatory mechanisms of antibiotic production.
  Design, Synthesis and Biological Evaluation of novel inhibitors of the JAK-STAT signalling pathway with potential application as immune oncology agents
  Dr R Whitehead, Dr K Finegan, Prof N Turner
Applications accepted all year round

Funding Type

PhD Type

Small molecule inhibitors of the JAK-STAT signalling pathway often possess interesting biological properties with many displaying potent anti-proliferative activity towards cancer cell lines.
  Engineering synthetic ribosomal RNAs (rRNAs) in yeast
  Prof P Cai, Prof D Delneri
Application Deadline: 31 July 2020

Funding Type

PhD Type

Advances in DNA synthesis technology have led to rapid growth in the field of synthetic biology, heralding a nascent era of synthetic genomics.
  Establishing NMR chemical shifts as reliable reporters of atomic charge distributions in enzymes
  Prof J Waltho, Prof P Popelier
Applications accepted all year round

Funding Type

PhD Type

Enzymes are not only central to life but also to the growing need to harness elements of the natural world to the benefit of mankind.
  Expanding the Genetic Code of a Synthetic Yeast
  Prof P Cai, Dr A Green
Applications accepted all year round

Funding Type

PhD Type

The proposed project aims to develop an efficient yeast-based protein expression platform with an expanded genetic code. The standard genetic code of natural organisms comprises 20 canonical amino acids.
  Integrating chemocatalysis and biocatalysis to create new synthetic pathways (iCBPATH)
  Prof J Micklefield, Prof M Greaney
Applications accepted all year round

Funding Type

PhD Type

In this project, we aim to combine the power of enzymatic C-H bond functionalisation and transition metal catalysis to construct complex molecules in a single reaction providing new, more efficient and rapid routes to pharmaceuticals and other essential products.
  Modelling photosynthetic water oxidation
  Dr P O'Malley
Applications accepted all year round

Funding Type

PhD Type

This project aims use molecular modelling methods and spectroscopy to understand how the protein environment of electron transfer cofactors in photosysnthesis and in particular how the water oxidising complex, facilitates electron transfer and also helps stabilise these radical species to maintain a charge separated state.
  Molecular mechanisms of herpesviral infection
  Dr A Golovanov
Applications accepted all year round

Funding Type

PhD Type

Herpes viruses are known to cause a wide range of human diseases, ranging from simple cold sores to cancer, Kaposi Sarcoma. Kaposi Sarcoma, for example, is a type of cancer which affects immunocompromised patients and is endemic in Africa, where it is linked with the spread of HIV infection and AIDS.
  Nanoparticle conjugates for agricultural disease detection and diagnosis
  Dr L Wong, Prof J Micklefield
Applications accepted all year round

Funding Type

PhD Type

Infectious diseases in plant crops present a significant socioeconomic burden globally, as they compromise the safety and reliability of food supply, as well as other agricultural products.
  New NMR methods for complex mixture analysis
  Prof M Nilsson, Prof GA Morris
Applications accepted all year round

Funding Type

PhD Type

Applications are invited from students with independent funding for PhD research in the development and application of novel methods in NMR spectroscopy.
  Ruthenium-catalysed C-H late stage functionalisation of biologically active compounds
  Prof I Larrosa, Dr J Bures
Applications accepted all year round

Funding Type

PhD Type

This project will involve work in the catalytic C–H activation area.
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