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University of Sheffield, Department of Chemistry PhD Projects, Programs & Scholarships

We have 30 University of Sheffield, Department of Chemistry PhD Projects, Programs & Scholarships

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Department of Chemistry  University of Sheffield

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We have 30 University of Sheffield, Department of Chemistry PhD Projects, Programs & Scholarships

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Microporous Polymer Catalysts

Porous materials such as naturally occurring and synthetic zeolites are widely used in industry as heterogeneous catalysis due to their high internal surface areas. Read more

Dispersible Microporous Polymers

Porous materials are of interest due to their high surface areas which can be used to adsorb wide range of molecules for a variety of applications, however they are typically insoluble, difficult to process and limited to applications in the solid state. Read more

A Pd-catalysed cyclisation strategy to chiral nitrogen heterocycles

We have recently devised a novel conjunctive reagent that is generated in the presence of a palladium catalyst, and demonstrated that this can be exploited in the synthesis of chiral heterocyclic products. Read more

Transition metal complexes making light of cancer

Cancer is one of the leading causes of death around the world. Although existing chemotherapy regimens are often successful in curing many common cancers, they frequently cause serious and unwanted side-effects. Read more

New anticancer therapies based on transition metal complexes

Cancer is one of the leading causes of death around the world. Over 50% of cancer tumours are treated with platinum-based metal complexes, like cisplatin and its derivatives. Read more

Precise, peptide-directed loading of drugs onto therapeutic antibodies for targeted imaging and treatment of tumors.

The PhD project aims to develop a non-covalent technology for loading small molecules and therapeutic enzymes onto monoclonal antibodies thus addressing issues in preparations of antibody-drug conjugates, such as poor yields and non-specific conjugation of the drugs resulting in compromised immunoaffinity. Read more

Does membrane repair fail to alert the immune system to disease?

The cGAMP-synthase cGAS recognises microbial or self-DNA to activate STING and induce the release of pro-inflammatory molecules. But cytoplasmic DNA is also particularly abundant in cancer cells, under the form of genomic structures called ‘micronuclei’. Read more

An asymmetric synthesis of atropisomeric functionalised intermediates

Atropisomers are stereoisomers that occur because of hindered rotation about a single bond, and this leads to two or more conformers that interconvert slowly enough to be isolated as single components. Read more

Catalytic asymmetric methods to make chiral building blocks

There is increasing need within the pharmaceutical and fine chemical sector to develop chemical building blocks that possess different shapes and morphology to those commonly used to construct molecules of biological interest. Read more

Chemical probes to investigate mechanisms of bacterial resistance

Antibiotic resistance is seen as a significant threat to modern healthcare, especially in light of an increasing and aging population who will place additional burden on this sector. Read more

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