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University of York, Department of Chemistry PhD Projects, Programs & Scholarships

We have 26 University of York, Department of Chemistry PhD Projects, Programs & Scholarships

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  A dynamic biomaterial-ligand tethering strategy for tissue engineering
  Dr C Spicer, Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Biomaterials that can trigger the repair of damaged tissues have the potential to revolutionise the way we treat disease. Materials that can present cells and tissues with powerful biochemical signals, through attached peptides, proteins, and carbohydrates, are particularly effective at controlling regeneration.
  A new route to functionalised, stable Blatter-type free radicals
  Dr V Chechik
Applications accepted all year round

Funding Type

PhD Type

Although most free radical are highly reactive and have very limited lifetime, some possess excellent stability. The magnetic properties of unpaired electron make such radicals promising building blocks for magnetic materials.
  Automated synthesis of oligosaccharides
  Dr M A Fascione
Applications accepted all year round

Funding Type

PhD Type

Carbohydrates play important roles in a number of biological processes including tumour metastasis, bacterial and viral recognition, and the immunological response.
  Biomass derived synthetic polymers
  Prof M North
Applications accepted all year round

Funding Type

PhD Type

Polymers are produced on a multi-million tonne scale per annum and are a high priority to move from non-sustainable petroleum based to sustainably based starting materials.
  Brønsted Acid Catalysed Asymmetric Synthesis of Cyclic Ethers
  Dr P Clarke
Applications accepted all year round

Funding Type

PhD Type

Over recent years there has been a drive by medicinal chemists to explore more 3-dimensional areas of chemical space. Cyclic ethers, such as the tetrahydropyran (THP) and the tetrahydrofuran (THF) rings, are the most common and 6th most common saturated heterocyclic function present in marketed pharmaceuticals.
  Conformational dependence of glycan geometry in protein glycosylation: applications for macromolecular refinement in atomic structure determination by X-ray crystallography and electron cryo-microscopy
  Dr J Agirre, Dr K D Cowtan
Applications accepted all year round

Funding Type

PhD Type

Proteins are composed of 20 individual building blocks, the L-amino acids, linked together by a largely inflexible amide bond.
  Cooperative, non-specific binding and aggregation in protein/RNA interactions: Beyond stoichiometry, specificity, and discrete binding sites
  Dr S Shimizu, Dr M Plevin
Applications accepted all year round

Funding Type

PhD Type

Interactions between biomolecules are typically considered to be both specific and stoichiometric. Even in cases of multiple binding sites, cooperative binding models have been successful in reproducing the sigmoidal binding curves seen in experiment (e.g., hemoglobin).
  Decision making through artificial chemical intelligence
  Dr J Slattery, Prof I J S Fairlamb
Applications accepted all year round

Funding Type

PhD Type

Automation will transform the chemical landscape. Powerful robotic platforms can perform reactions or analyses much more rapidly than traditional approaches.1 Ever faster computers allow huge numbers of molecules to be studied in an automated way using computational chemistry.
  Developing Magnetic Resonance Targeting Methods
  Dr A Kennerley
Applications accepted all year round

Funding Type

PhD Type

Magnetic resonance targeting (MRT) is a novel method which repurposes the imaging gradient coils, inherent in most clinical magnetic resonance imaging (MRI) systems, to essentially steer super paramagnetic iron oxide (SPIO) labelled particles to a target regions deep within a sample.
  Dual-Action Anti-Cancer Drug Delivery Vehicles
  Prof D K Smith
Applications accepted all year round

Funding Type

PhD Type

Cancer is a challenging disease target, and requires wide-ranging strategies for intervention. Given the difficulties in treating recalcitrant tumours, multi-mode therapies are of significant potential value.
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