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Norwich Research Park Featured PhD Programmes

University of Cambridge, Department of Clinical Neurosciences PhD Projects, Programs & Scholarships

We have 14 University of Cambridge, Department of Clinical Neurosciences PhD Projects, Programs & Scholarships

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Department of Clinical Neurosciences  University of Cambridge

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We have 14 University of Cambridge, Department of Clinical Neurosciences PhD Projects, Programs & Scholarships

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Neural Stem Cell Niche Interactions in Mitochondrial Disease

Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present late in life, with very tissue-specific phenotypes. Read more

Multiparametric MRI and PET Biomarkers of Glioblastoma

Glioblastoma is the most aggressive brain tumour in adults, characterised by remarkable heterogeneity and dismal outcome. Developing non-invasive imaging biomarkers promises to provide crucial clinical decision support and inform precision medicine. Read more

Elucidation of Initiating Cell and Molecular Pathologies in Human CNS Organoid Models of Neurodegeneration

Several potential projects are available in the Lakatos Lab. Our overarching theme concerns investigations of the relationship between the genetic risks and early sequences of molecular dysfunction that lead to disturbances of genomic stability, transcriptional/signalling networks and proteostasis. Read more

Investigating the Immunological Basis of Inflammatory Neuropathies

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease in which the patient’s own immune system mistakenly attacks and destroys the protective fatty covering (myelin) of their peripheral nerves, leading to progressive proximal and distal weakness. Read more

Developing a New Model for Vascular Stroke using Human Induced Pluripotent Stem Cells (hiPSC) with the HDAC9 Risk Genetic Variant

A quarter of all stroke is classified as large artery stroke, most of which are attributed to atherosclerosis. Together with conventional risk factors, there is evidence that a strong heritable genetic component contributes to large artery stroke risk. Read more

Developing Novel Treatments for Children with Inherited Neuromuscular Diseases

Inherited neuromuscular disorders are disabling, progressive, often fatal conditions, representing an enormous unmet medical need with devastating impacts on affected families, the healthcare system, and the economy. Read more

Brain Repair in Adults and Children with Multiple Sclerosis

We are interested in the process of remyelination in humans, especially in assessing how the rate of remyelination changes with age and how best to test drugs that potentially promote remyelination. Read more

Apathy in Huntingtons Disease

Apathy is a common and disabling feature of Huntington’s disease (HD) with patients and families ranking it as one of the top three most impactful features of the disease. Read more

Development of Novel Molecular Imaging Probes for Neuroimaging by Positron Emission Tomography (PET)

The overarching objective of these projects is to develop novel molecular imaging probes, including PET probes, for imaging neuropathological features associated with various disorders such as neurodegeneration, neuroinflammation, multiple sclerosis and mitochondrial disorders. Read more

The Genetic Analysis of Multiple Sclerosis

Through genome-wide association studies and related follow up efforts we have identified over 100 genetic variants that influence the risk of developing multiple sclerosis. Read more

Functional MRI Imaging in Traumatic Brain Injury

CENTER-TBI is a large European project that aims to improve the care for patients with Traumatic Brain Injury (TBI). The work undertaken in Cambridge will examine the role of MRI in routine TBI imaging and this project will focus on the role of resting state functional MRI in TBI imaging. Read more
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