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We have 17 University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

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Department of Genetics and Genome Biology  University of Leicester

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University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

We have 17 University of Leicester, Department of Genetics and Genome Biology PhD Projects, Programmes & Scholarships

Natural products in bacterial physiology and chemical interaction

Microbial natural products have diverse chemical structures and bioactivities, which range from cell-cell signalling, nutrient acquisition, antifungal and antibacterial activity to stress resistance (1). Read more

Short and long-term genetic and behavioural consequences of traumatic brain injury in fruit flies

General background . How many fingers am I holding up? What day of the week is it? Follow my finger? These three questions are designed to test your sensory, memory and motor neural abilities following an accident; all three systems are affected by a severe deceleration of your brain. Read more

Epigenetic ageing and calorie restriction in an insect model system

This project will help establish an insect model for epigenetic ageing, by analysing the effects of calorie restriction on chronological and epigenetic aging in an important insect model, Nasonia vitripennis, extending our discovery of an epigenetic clock in Nasonia. . Read more

Investigating the role of SUMOylation in meiotic recombination and chromosome segregation in Arabidopsis

  Research Group: Midlands Integrative Biosciences Training Partnership (MIBTP)
Post-translational modifications of proteins such as phosphorylation, methylation and acetylation have been extensively studied in eukaryotes and now the Small Ubiquitin modifier (SUMO) is gaining attention for its importance in fundamental biological roles. Read more

Unlocking the genetic potential of barley by modulating recombination

Barley is a major worldwide crop used for malting and animal feed. However, breeding new varieties is constrained by the frequency of genetic crossovers (1-3 crossovers per chromosome pair) and their distribution (biased towards the chromosome ends) that underpin crop improvement1,2. Read more

Enhancing meiotic recombination in wheat by modulating RECQ helicases

Wheat accounts for 20% of the calories and protein consumed by humans and is the largest crop in the UK, but yields have plateaued and are susceptible to decline due to extreme weather conditions. Read more

Exploring the role of tryptophan metabolism in schizophrenia pathogenesis

L-kynurenine (KYN) and kynurenic acid (KYNA) are metabolites of the kynurenine pathway (KP) of tryptophan degradation and have been found to be increased in the brains of patients with schizophrenia. Read more

The Evolution of Vision in Mosquitoes

Background . Due to their capacity to transmit viruses such as Zika and parasites like Plasmodium (the causative agent of malaria), mosquitos are regarded by the World Health Organization as one of the most lethal organisms on our planet (WHO | Global vector control response 2017–2030, 2020). Read more

Identifying the neurogenetic network underlying visually-driven sleep

General background. Sleep is a behavioural quiescence widely observed in the animal kingdom. During sleep, an animal’s motor activity, as well as their responsiveness to environmental stimuli, are largely reduced. Read more

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