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University of Sheffield, Department of Infection, Immunity and Cardiovascular Disease PhD Projects, Programs & Scholarships

We have 16 University of Sheffield, Department of Infection, Immunity and Cardiovascular Disease PhD Projects, Programs & Scholarships

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  A Twist In The Mechanism of Heart Disease
  Prof P Evans
Applications accepted all year round

Funding Type

PhD Type

Atherosclerosis is a leading cause of death in the UK. It is characterized by the build-up of fatty plaques in arteries. Some plaques are stable whereas others develop into dangerous forms that are vulnerable to rupture, an event that causes heart attack and stroke.
  Bacterial iron uptake pathways as targets for the development of novel antimicrobials
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is an ever increasing problem. Presently it is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050.
  Characterisation of bacterial effectors delivered by the type VI secretion system
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Many pathogenic bacteria secrete protein ’effectors’ that benefit the pathogen by allowing it to subvert, damage or kill the host.
  Defining strategies to promote immunity to multi-drug resistant Staphylococcus aureus.
  Dr L Prince
Applications accepted all year round

Funding Type

PhD Type

Staphylococcus aureus is a highly successful pathogen that can circumvent many aspects of immunity. White blood cells, including neutrophils, are a critical defence against infection and yet S.
  How does cytokine signalling cause kidney hyperplasia?
  Dr M Fragiadaki, Prof J Sayers
Applications accepted all year round

Funding Type

PhD Type

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disorder, with more than 12 million people are affected worldwide.
  How to eat big, small and irregular: Force generation in phagocytic immune cells
  Dr S Johnston, Dr R Hawkins
Application Deadline: 29 January 2020

Funding Type

PhD Type

Phagocytosis (eating) of microbes, dead cells and particulates by immune cells is critical for health and protecting against disease.
  Identifying inhibitors specific to the OPG-kinome: towards novel treatments for Pulmonary Arterial Hypertension (PAH).
  Prof A Lawrie, Dr R Thompson
Applications accepted all year round

Funding Type

PhD Type

Background. Pulmonary arterial hypertension (PAH) is a fatal progressive disease. Median life expectancy in untreated PAH patients is 2.8 years.
  Machine Learning Methods for Behaviour Analysis in Cardiovascular Disease
  Prof T Chico, Prof L Mihaylova
Application Deadline: 29 January 2020

Funding Type

PhD Type

Cardiovascular diseases affect patient’s day-to-day activities by causing symptoms such as breathlessness on exertion but there is no effective way to measure this.
  Optogenetic programming of inflammation - in vivo Opto-GPCR approaches in neutrophils.
  Prof S Renshaw, Prof A Condliffe
Application Deadline: 29 January 2020

Funding Type

PhD Type

White blood cells called neutrophils have a powerful protective role and without them we develop overwhelming infection, yet they are also directly responsible for the tissue damage that characterises many common inflammatory diseases.
  Project title: Elucidating the mechanisms of pathology in neurodevelopmental white matter diseases
  Dr N Hamilton
Applications accepted all year round

Funding Type

PhD Type

Our research interest is to dissect the mechanism of auto-inflammatory neurological disorders using zebrafish as an animal model.
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