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University of Sheffield, Department of Molecular Biology and Biotechnology PhD Projects, Programs & Scholarships

We have 25 University of Sheffield, Department of Molecular Biology and Biotechnology PhD Projects, Programs & Scholarships

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  Addressing the functional significance of distinct paths to catalytic sites within the exosome
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

The exosome RNase complex contains two associated catalytic subunits, one of which has two distinct catalytic sites (Mitchell, 2014).
  Analysis of the exoribonuclease Rex1
  Dr P Mitchell
Applications accepted all year round

Funding Type

PhD Type

Inhibition of one exosome catalytic subunit renders cells dependent upon another RNase called Rex1.
  Bactofilins and the bacterial cytoskeleton
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Newly developed light and electron microscopy methods are revolutionising our understanding of bacterial cells. Once thought to be simple, bacteria have now been recognised at highly organised cells using many elements previously only known from eukaryotes.
  Biogenesis of the Clostridium difficile cell surface
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Clostridium difficile infection (CDI) is a major cause of morbidity and mortality in our hospitals. Infection normally follows disruption of the gut normal flora by broad-spectrum antibiotic treatment.
  Biophysics of enzyme-catalyzed phosphoryl transfer
  Prof J P Waltho
Applications accepted all year round

Funding Type

PhD Type

Using a combination of multinuclear NMR spectroscopy, high resolution X-ray crystallography, synthetic chemistry and computational chemistry we have explored the conformational behaviour of enzymes under a very wide range of conditions.
  Development of a novel immunotoxin
  Dr L J Partridge
Applications accepted all year round

Funding Type

PhD Type

Immunotoxins represent a form of immunotherapy whereby antibodies are used to target a toxin, usually to cancer or infected host cells.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  Engineering E. coli as a cell factory for biotechnology
  Dr J Green
Applications accepted all year round

Funding Type

PhD Type

The model bacterium Escherichia coli is metabolically versatile with ability to adapt to ever changing environmental conditions by reprogramming gene expression.
  Functional analysis of novel genes important in the physiology and pathogenesis of the human pathogen Campylobacter jejuni
  Prof D J Kelly
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni and E. coli are the commonest cause of human bacterial gastroenteritis worldwide. Although pathogenic in humans, C.
  Gliding motility in bacteria
  Dr E Hoiczyk
Applications accepted all year round

Funding Type

PhD Type

Motility is important for bacterial survival and facilitates colonisation and dispersal of bacteria. While swimming and type IV pili-based swarming is relatively well understood, gliding or adventurous motility, a form of surface-associated motility is still enigmatic.
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