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University of Sheffield, Department of Oncology and Metabolism PhD Projects, Programs & Scholarships

We have 20 University of Sheffield, Department of Oncology and Metabolism PhD Projects, Programs & Scholarships

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  Actin regulation of nuclear mechanics during DNA repair
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

In eukaryotic cells, the nucleus houses the genomic material and transcription machinery that allows the cell to develop and perform its role.
  Adrenomedullin-2 receptor antagonists in T-cell lymphoma
  Dr G Richards, Prof T Skerry
Applications accepted all year round

Funding Type

PhD Type

Cancer cells rely upon communication between themselves and to the host tissues to survive and grow. One hormone involved in cancer signalling is adrenomedullin (AM), which also has important physiological roles in the control of blood pressure.
  Bacterial-derived magnetosomes as nanocarriers for cancer-killing oncolytic viruses.
  Dr M Muthana, Dr F Howard
Applications accepted all year round

Funding Type

PhD Type

Dysfunctional cellular processes that are the markers of neoplasms provide the ideal environment for viral infection including sustained proliferation and resistance to cell death.
  Combined targeting of PD-L1 and NFκB pathways to reverse T-cell exhaustion and restore anti-tumour immunity in breast cancer.
  Dr A Idris
Application Deadline: 1 July 2020

Funding Type

PhD Type

The majority of deaths from breast cancer following conventional therapies are a result of metastases. Programmed death 1 ligand (PD-L1), a negative regulator of the immune system, is highly expressed in triple negative breast tumours and cell lines, and its expression is associated with suppressed anti-tumour immunity.
  Evaluation of ex vivo screening methodology
  Dr S Danson, Prof T Helleday
Applications accepted all year round

Funding Type

PhD Type

Cancer affects over 14M individuals worldwide each year and in the UK only 50% of patients have a 10 year survival following cancer diagnosis.
  Evaluation of natural and novel tumour-selective cannabinoids in melanoma progression and metastases
  Dr A Idris, Dr S Danson
Application Deadline: 1 July 2020

Funding Type

PhD Type

The majority of deaths from melanoma following conventional therapies are a result of metastases.
  Ex vivo drug screening using human tissue to personalise cancer therapy and replace murine avatars for high-grade brain tumours
  Prof T Helleday, Dr S Collis
Application Deadline: 31 January 2020

Funding Type

PhD Type

Supervisor(s). Principle Investigator; Prof Thomas Helleday, Co-investigators Dr. Spencer Collis, Dr. Juha Rantala, Mr. Ola Rominyi and Dr.
  High-throughput mechanobiology
  Dr C Toseland
Applications accepted all year round

Funding Type

PhD Type

Cancer research has traditionally focused upon extra- or intra-cellular biochemical signals, and their relation to cancer development and metastasis.
  MicroRNA and Extracellular Vesicles Mediation of Embryo-Maternal Communication
  Prof A Fazeli, Dr P Heath
Applications accepted all year round

Funding Type

PhD Type

Infertility is a substantial problem affecting couples worldwide. The scars inflicted on couples as a result of not being able to conceive affects their general health, mental well-being and even raising social issues particularly in the old age.
  Multi-scale models for the prediction of bone remodelling due to musculoskeletal interventions
  Dr E Dall'Ara, Prof V Kadirkamananthan, Prof I Bellantuono
Application Deadline: 29 January 2020

Funding Type

PhD Type

Musculoskeletal diseases as osteoporosis have huge impact on the mortality and morbidity of our ageing society. At the moment there are some pharmacological interventions for treating osteoporosis but they are not effective in all patients and their cost is very high.
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