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University of Sheffield, Department of Oncology and Metabolism PhD Projects, Programmes & Scholarships

We have 17 University of Sheffield, Department of Oncology and Metabolism PhD Projects, Programmes & Scholarships

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Department of Oncology and Metabolism  University of Sheffield

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We have 17 University of Sheffield, Department of Oncology and Metabolism PhD Projects, Programmes & Scholarships

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Developing new treatment combinations to target dormant cancer cells in myeloma

Multiple myeloma is the second most common blood cancer and remains essentially incurable. Chemotherapy is effective at reducing tumour and extends survival, but it never fully eradicates disease, so patients face inevitable relapse. Read more

Advanced 3D models for Cancer Research

Radiotherapy and many chemotherapies kill cells by damaging DNA. The efficiency of these DNA damaging agents differs between tumour types and individual patients. Read more

The role of vimentin in cell adhesion and motility in disease

This role supports an active research program to assess the molecular mechanisms underlying adhesive, mechanical and motile changes in cells as they relate to vimentin, the intracellular protein, and its assembled filamentous form in vimentin intermediate filaments. Read more

Combined targeting of PD-L1 and TRAF6 pathways: Implications for Cancer Treatment

The majority of deaths from advanced, difficult-to-treat cancers are a result of metastases. Programmed death 1 ligand (PD-L1), a negative regulator of the immune system, is highly expressed in metastatic cancer cells, and its expression is associated with suppressed anti-tumour immunity. Read more

Differential effects of Cannabidiol: Mechanism(s) of Action and Implications in Cancer

Increasing social acceptance of the ‘non-intoxicating’ cannabidiol (CBD) – one of the major bioactive and non-psychoactive cannabinoids in cannabis sativa – have accelerated its availability and on-/off-label use around the globe. Read more

Validation of TRAF6/PD-L1 inhibition in pre-clinical models of multiple myeloma: implications for combinational immunotherapy

Programmed death-ligand 1(PD-L1), a negative regulator of the immune system, is highly expressed in newly-diagnosed and relapsed multiple myeloma patients, and its expression is associated with suppressed anti-tumour immunity. Read more

Prostate cancer signalling to the bone micro-environment - from molecular characterization to potential novel therapies.

About the Project. Prostate cancer is responsible for over 52,000 cancer diagnoses within the UK per annum, and is the most common cancer in males, accounting for 27% of all new cancer cases diagnosed within men in 2016-2017. Read more

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