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University of Oxford, Department of Oncology PhD Projects, Programs & Scholarships

We have 23 University of Oxford, Department of Oncology PhD Projects, Programs & Scholarships

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  Autoimmunity against TNF and its role in inflammatory diseases
  Dr S Jiang, Dr N Burgess-Brown
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Tumour Necrosis Factor (TNF) is a pro-inflammatory cytokine. It regulates a complex signalling network able to trigger cell survival, as well as cell death via apoptosis or necrosis/necroptosis.
  Bispecific monoclonal antibodies for cancer immunotherapy
  Prof W Bodmer, Prof P McHugh
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Monoclonal antibodies (MCAs) are now widely used for cancer therapy. DNA recombinant technology enables the production of MCAs that target cancer specific determinants and immune cells, attracting them to the cancer cells and so killing them.
  Characterisation of DNA-protein crosslink proteolysis repair in cancer and therapy
  Prof K Ramadan, Prof B Kessler
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. DNA-protein crosslinks (DPCs) are under-investigated DNA lesions caused by the covalent attachment of proteins to DNA.
  Combining CRISPR and RNAseq to dissect molecular circuits in a hypoxic tumour microenvironment
  Prof F Buffa, Prof A Harris, Dr V D'Angiolella
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. The role of the microenvironment in driving tumour progression is increasingly recognized. Hypoxia is one of the key microenvironmental changes between tumour and normal tissue, and adaptation of cancer cells to this hostile environment contributes to their malignancy and aggressive phenotype.
  Cross presentation of antigens of recombinant overlapping peptides to optimise vaccines against tumour and infectious diseases
  Dr S Jiang, Dr N Burgess-Brown
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. We have developed a technology to producing overlapping peptides - bacterial expression of an amino acid sequence corresponding to overlapping peptide sequences spanning the length of a protein of interest interspersed with enzymatic cleavage sites.
  Differentiation in colorectal cancer
  Prof W Bodmer, Prof P McHugh
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Derangement of cellular differentiation is a key step in adenocarcinoma progression. Understanding this should provide novel targets for the development of new treatments, and new approaches to diagnosis and early detection.
  DNA repair fidelity, radiosensitivity and cancer.
  Prof T Humphrey, Dr V D'Angiolella
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. With almost half of all cancer patients receiving radiotherapy, tumour-specific radiosensitization remains an important goal for cancer research.
  Early detection of oesophageal cancer
  Prof K Vallis, Prof B Vojnovic
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Oesophageal cancer is an area of unmet clinical need; late diagnosis is one of the reasons that cure rates remain stubbornly low.
  Exosomes in oncolytic virotherapy
  Prof L Seymour, Dr K Fisher
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Oncolytic viruses promise new opportunities for targeted cancer therapy, but spread of viruses through solid tumour masses is often limited.
  Hypoxia links the unfolded proteim response with the DNA damage response
  Prof E Hammond, Prof A Giaccia
Application Deadline: 3 March 2020

Funding Type

PhD Type

THE PROJECT. Regions of hypoxia (insufficient oxygen) occur in most if not all solid tumours and are clinically relevant as they correlate with poor patient prognosis and therapy resistance.
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