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We have 111 Developmental Biology PhD Projects, Programmes & Scholarships for European Students (exc UK)
Developmental Biology PhD Projects, Programmes & Scholarships for European Students (exc UK)
We have 111 Developmental Biology PhD Projects, Programmes & Scholarships for European Students (exc UK)
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Development of antisense oligonucleotide and base editing therapeutics for neurodevelopmental haploinsufficiency disorders
Neurodevelopmental disorders constitute a group of diseases in which the normal development of the nervous system is disrupted and for which treatment options are currently very limited. Read more
A mechanistic understanding of how chemical contaminants affect marine invertebrates, using a common jellyfish as a model.
Project overview. Ecosystems are widely impacted by anthropogenic activities, including the release of chemicals. Scyphozoan jellyfish, in particular the common jellyfish Aurelia spp., are widespread in coastal environments subjected to a range of natural and anthropogenic stressors. Read more
Adaptation to extreme environments: Evolution of unusual body plans in Southern Ocean Echinoids
Project overview. The deep, cold waters of the Southern Ocean are home to enigmatic, morphologically unusual radiation of sea urchins belonging to the Holasteroida. Read more
Modelling Cellular Differentiation during Neural Crest Development
During embryonic development, diverse cell types are produced to establish the form and function of the mammalian body. Critical to this process is the differentiation of neural crest cells (NCCs) – a progenitor cell that has the potential to form multiple cell types. Read more
Epigenetic reprogramming in the germ line: the role of an unusual chromatin composition in the pre-meiotic germ cells
Using mouse embryonic development as an experimental model, our long term interest is how epigenetic information is propagated during development and erased in the context of the germ line (zygotic and germline reprogramming). Read more
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Using human organoids to unravel epigenetic mechanisms in health and Inflammatory Bowel Diseases
Project Overview. The intestinal epithelium provides a critical barrier that contributes towards the establishment of a finely tuned homeostasis in the human gut. Read more
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Mechanisms regulating blood stem cell self-renewal and differentiation
Project Overview. The Wilkinson research group focuses on the biology and translational applications of blood-forming haematopoietic stem cells (HSCs). Read more
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Therapeutic vulnerabilities of TET2-mutant clonal haematopoiesis
Project Overview. Read more
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Cancer-associated sensitisation mechanisms to selective RNA methyltransferase inhibition
Project Overview. Epitranscriptomics, the modulation of RNA function via its chemical modification, has emerged as a pervasive new mechanism of gene regulation. Read more
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Multiomics to decipher T cell development in the thymus
Project Overview. Ongoing projects in the Teichmann team are generating scRNA-seq and chromatin accessibility profiles of thymic cells using the 10X multiome kit, combined with multiplex protein staining. Read more
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Unravelling The Parallels Between Regeneration & Tumorigenesis
Project Overview. Some organisms, such as salamanders, retain a remarkable capacity for regeneration in various organs, which occurs through the process of epimorphic regeneration. Read more
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Patient outcomes and new therapies in aortic aneurysm using iPSC ‘disease-in-a-dish’ models
Project Overview. We have pioneered the use of induced pluripotent stem cells from patients with genetically mediated aortic aneurysms (such as Marfan and Loeys-Dietz syndromes) to set up ‘disease-in-a-dish’ in vitro models (PMIDs. Read more
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Understanding the stress biology underlying human haematopoietic stem cell adaptation to clinically-relevant ex vivo culture
Project Overview. Haematopoietic Stem Cell (HSC) Gene Therapy (GT) is the only curative option for many monogenic inherited disorders. Read more
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The tipping point: what drives the progression of breast precancer cells
Project Overview. Understanding the molecular and cellular mechanisms of how epithelial tissues maintain a homeostatic state throughout the lifespan of mammals is a major challenge for developmental and stem cell biology. Read more
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Rethinking the human proteome: bioactive microproteins in non-Hodgkin lymphoma
Project Overview. The human genome is believed to contain approximately 20,000 protein-coding genes. These were originally annotated based on criteria for predicting synthesis of stable proteins, including an arbitrary size threshold of 100 amino acids. Read more