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Dundee×
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Biochemistry PhD Projects, Programs & Scholarships in Dundee

We have 14 Biochemistry PhD Projects, Programs & Scholarships in Dundee

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Showing 1 to 10 of 14
  Predicting the conversion of LRRK2 carriers to Parkinson disease: the role of blood and CSF biomarkers
  Dr E Sammler
Applications accepted all year round
Parkinson’s disease is a progressive neurodegenerative disease affecting up to 1:500 people over the age of 50 years.1 The risk of developing Parkinson’s…
  Enabling Precision Medicine through Oesophageal Cancer Proteogenomics
  Prof R Petty, Prof A I Lamond
Applications accepted all year round
Capitalising on technological advances in next generation sequencing, genomic landscaping projects have provided a comprehensive catalogue of genetic abnormalities in human cancer, and in some tumour types provided classifications useful for clinical decision making.
  Interdisciplinary investigation of the role of amino acids in immunometabolic responses to metformin in humans
  Dr G Rena, Prof C Lang
Applications accepted all year round
There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD)but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD.
  Interdisciplinary investigation of a large effect of sulfasalazine on HbA1c
  Dr G Rena, Prof E Pearson
Applications accepted all year round
The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1].
  Regulation of mTOR by pharmacological activators of transcription factor Nrf2
  Prof A Dinkova-Kostova
Applications accepted all year round
The mechanistic target of rapamycin (mTOR) is a kinase, which is the core component of two protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), and has a fundamental role in the maintenance of cellular homeostasis.
  Molecular and physiological dissection of the unexpected metabolic actions of the DNA repair gene ataxia-telangiectasia mutated (ATM).
  Dr C Sutherland, Prof R McCrimmon, Prof E Pearson
Applications accepted all year round
Metformin is recommended as first line oral therapy in Type 2 diabetes (>200 million people world wide) in all international guidelines.
  Establishing the potential of GSK3 manipulation for the treatment of human leukaemias
  Dr C Sutherland, Dr S Tauro
Applications accepted all year round
Background. Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world.
  Targeting the Achilles’ heel – dissecting drug resistance in ovarian cancer
  Dr G Smith, Dr M Ferguson
Applications accepted all year round
Ovarian cancer, the most common cause of gynaecological cancer death, is frequently diagnosed when the disease is already advanced, when surgery is not always possible.
  Chemical profiling of ubiquitin conjugation enzymes
  Dr S Virdee
Application Deadline: 31 March 2019
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Satpal Virdee. A PhD project in the Virdee lab is available involving the development of chemical tools known as activity-based probes (ABPs).
  Define the molecular mechanisms by which PAWS1 controls Wnt signalling
  Dr G Sapkota
Application Deadline: 31 March 2019
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Gopal Sapkota. Wnt signalling plays a fundamental role during development and in adult tissue homeostasis.
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