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We have 68 Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Dundee
Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Dundee
We have 68 Biological Sciences PhD Projects, Programmes & Scholarships PhD Projects, Programmes & Scholarships in Dundee
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MSc by Research: Bringing proteins together with functional small molecules
Recent advances from the Ciulli Lab and others have contributed to the establishment of a game-changing new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
MSc by Research: How are SUMO substrates selected for modification ?
SUMO has diverse roles in cellular physiology that in most cases are mediated by its ability to interact non-covalently with hydrophobic patches of low sequence complexity known as SUMO Interaction Motifs (SIMs). Read more
MSc by Research: Regulation of T cell function by SIK3 in viral infection
T cells play critical roles in the host response to viral infection. Activated cytotoxic CD8 T cells are able to kill virally infected cells while… Read more
MSc by Research: Investigation of mitochondrial biology and neurodegeneration
Phosphorylation and ubiquitylation are reversible signalling events and there is significant interest in in their interplay in the regulation of normal biological processes and disruption in human diseases. Read more
MSc by Research: Understanding the beginning of life: the role of non-canonical ubiquitylation in early embryonic development
Ubiquitin is a small, yet influential, protein that is attached to other substrates to control their stability or activity in a process called ubiquitylation. Read more
MSc by Research: Non-canonical functions of SRSF protein kinase (SRPK) in pluripotent stem cells
The overarching goal of our research is to identify and characterise the protein kinase signalling pathways that control stem cell pluripotency and differentiation and determine how protein kinase signalling is disrupted to cause human developmental disorders. . Read more
MSc by Research: Understanding temperature-dependent virulence regulation in bacterial pathogens
Bacterial pathogens respond rapidly to environmental change, in ways that can influence their growth, virulence, antimicrobial resistance and, therefore, infection outcomes. Read more
Structural and Mechanistic Chemical Biology of Degraders Mode of Actions
Pioneering discoveries from the Ciulli Laboratory have contributed to the establishment of a new modality of chemical intervention into biological systems. Read more
The influence of individual differences in brain rhythms on language and music competency
The PhD project will aim to answer the question why some individuals have better speech comprehension skills or are more musical than others. Read more
Evaluating the therapeutic potential of leptin-based hexamers in neurodegenerative disease
Translation of basic research into Alzheimer’s disease (AD) therapies is hindered by our inability to turn promising lab results into drugs that can be taken by patients. Read more
How cells regulate chromosome segregation in mitosis and how this goes wrong in cancer
Human cells store their genetic information in 46 chromosomes. To maintain this vital genetic information, a complete set of chromosomes must be inherited precisely by each daughter cell after cell division. Read more
Epigenetic signalling in cancer
The advent of population scale tumour genomics has revealed that the genes encoding proteins that normally act to regulate chromatin structure are amongst the most frequently mutated genes in a range of cancers. Read more
How does Dysregulated Signal Transduction cause Intellectual Disability?
The goal of our lab is to understand how signal transduction is disrupted to cause intellectual disability, which is a major healthcare challenge world-wide. Read more
Bifunctional small molecules beyond PROTACs: Proximity-inducing new downstream chemistries to rewire cell signalling
Proteolysis targeting chimeras (PROTACs) are a popular class of bifunctional molecules that simultaneously engage a target protein on one end and an E3 ubiquitin ligase on the other end, forming a ternary complex that facilitates the rapid ubiquitylation and subsequent degradation of the target protein. Read more
Heat shapes plant growth - unravelling crosstalk between temperature and hormone signalling pathways in the control of leaf development
Ambient temperature has profound effects on almost all aspects of plant development, from the onset of seed germination and seedling establishment to flower and fruit production, and thereby also impacts crop quality and yield. Read more