Intellectual disability (ID) and concomitant developmental delay are severe neurodevelopmental conditions which affect approximately 1% of the world population.
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes.
The African trypanosome, Trypanosoma brucei, is transmitted among mammalian hosts by tsetse flies. These unicellular parasites cause sleeping sickness, also known as Human African Trypanosomiasis, which is typically fatal if left untreated, and the livestock disease known as nagana.
This project will essentially be data-driven, using large complex genomics and transcriptomics datasets and advanced bioinformatics to validate and expand gene networks and infer gene function.
Development of new drugs against parasitic diseases is a major need. We are studying a novel class of boron-containing drugs that have action against trypanosomatids, and for which we have evidence of multiple modes of action and activation.
In order to maintain genetic stability and prevent the amplification of chromosome segments, the process of DNA replication occurs in two strictly non-overlapping phases.
Preeclampsia occurs in 3-8% of all pregnancies causing rapid hypertension and kidney dysfunction in pregnant woman which is difficult to predict and untreatable.
