Protein phosphorylation is a critical post-translational modification needed for most biological responses. Although we have currently identified hundreds of thousands of different phosphorylation sites, we still lack one fundamental piece of information that is common to every single one of those sites.
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Prof. John Rouse. Our chromosomes are frequently subjected to insults that damage DNA, and if not rectified the resulting DNA lesions can cause mutations and human disease.
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Yogesh Kulathu. Cancer cells are heavily reliant on their ubiquitin proteasome system (UPS) to maintain proteostasis and cell survival.
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Gopal Sapkota. Wnt signalling plays a fundamental role during development and in adult tissue homeostasis.
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Ian Ganley. The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself).
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Prof. Dario Alessi. There is great need for improved understanding of the mechanistic biology underlying Parkinson’s disease.
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom. Dr. Adrien Rousseau. Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders.
