The aim of this project is to improve whole life construction productivity by defining new methods for the design and construction of durable concrete structures with complex geometries.
With the current focus on energy storage and replacement of fossil fuel driven vehicles with alternative power sources, a future shortage of global precious and important minerals has been recognised.
Chalk covers much of the UK and is widespread under the North and Baltic Seas. Foundations in chalk often pose particular problems because the complex collapsible rock behaviour.
Parkinson’s disease is a progressive neurodegenerative disease affecting up to 1:500 people over the age of 50 years.1 The risk of developing Parkinson’s…
Capitalising on technological advances in next generation sequencing, genomic landscaping projects have provided a comprehensive catalogue of genetic abnormalities in human cancer, and in some tumour types provided classifications useful for clinical decision making.
There is overwhelming evidence that inflammation contributes to the development of cardiovascular disease (CVD)but counterbalancing this is evidence from meta-analysis of randomised control trials that many existing anti-inflammatory drugs, such as COX2 inhibitors and anti-TNF drugs, tend if anything to exacerbate risk of CVD.
The anti-inflammatory drug sulfasalazine, which is used in rheumatoid arthritis and inflammatory bowel disease, was reported earlier to suppress HbA1c in a small cohort of patients [1].
The mechanistic target of rapamycin (mTOR) is a kinase, which is the core component of two protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), and has a fundamental role in the maintenance of cellular homeostasis.
