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We have 31 Structural Biology PhD Projects, Programmes & Scholarships in Dundee
Structural Biology PhD Projects, Programmes & Scholarships in Dundee
We have 31 Structural Biology PhD Projects, Programmes & Scholarships in Dundee
MSc by Research: Regulation and mechanics in polarized trafficking
Membranes and their protein organization are a frontier in our understanding of cell biology. We focus on polarized trafficking as a model to uncover fundamental mechanisms in the organization of structures at membranes. Read more
China Scholarship Council: Charting the atlas and mechanistic structural features of small-molecule degraders that glue intrinsic protein-E3 ligase interactions
Targeted protein degradation (TPD) is a new modality of chemical tools and drugs that trigger depletion of a target protein inside the cell. Read more
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EASTBIO: Designing Sticky Molecules to Capturing Biomolecular Complexes to Unravel Bystander Protein Ubiquitination
The "bystander effect" in protein ubiquitination, where both the target protein substrate and proteins bound to the substrate are tagged for ubiquitination by an E3 ubiquitin ligase, has been observed on several occasions, however, remains poorly understood. Read more
Understanding the beginning of life: the biological role of UBE2Q1 and non-canonical ubiquitination in mouse embryonic cells
Ubiquitination is a fundamental post-translational modification (PTM), which profoundly impacts diverse cellular functions, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune response. . Read more
Exploring Non-Canonical Ubiquitination and Its Biological Roles
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signaling, and immune responses. Read more
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Beyond Lysine: Exploring the Functional Consequences of Non-Canonical Ubiquitination in Health and Disease
Ubiquitination is a fundamental post-translational modification (PTM) crucial for a wide range of cellular processes, including protein degradation, localization, quality control, DNA repair, cell signalling, and immune responses. Read more
China Scholarship Council: PROTACs in plants - effectiveness, biological mechanisms and implications for use
Agriculture for the future. climate change, expanding populations, emerging pathogens and water constraints. . Food production must increase by 50% by 2050 to feed the global population in the face of climate change, while using less water, pesticide and fertilizer (UN FAO). Read more
MSc by Research: Deciphering the ubiquitin codes that regulate protein degradation
Ubiquitin signalling, which involves the posttranslational modification (PTM) of proteins with ubiquitin, regulates almost every aspect of eukaryotic biology. Read more
MSc by Research: Identifying and studying interacting proteins that are “glue-able” to small molecules
Recent advances from the Ciulli Lab and others have contributed to the establishment of a transformative new modality of chemical intervention into biological system – one that moves beyond the state-of-the-art. Read more
MSc by Research: Designing Molecular Glue Stabilizers to Restore Tumour Suppressor Function
Molecular glues, small molecules that facilitate the assembly of biomolecular complexes, have emerged as a transformative drug discovery strategy for treating diseases such as cancer and neurodegeneration. Read more
MSc by Research: Discovering the Biological Role(s) and Proteomic Impact of Non-Canonical Ubiquitylation
Ubiquitylation, the process by which the small protein ubiquitin is attached to target proteins, is a fundamental post-translational modification (PTM) that regulates almost every cellular function. Read more
MSc by Research: Feel the tension – how does S-acylation of OSCA ion channels regulate responses to environmental change in plants?
Plants, being sessile organisms, must sense and respond to environmental change, such as temperature or drought, without being able to move. Read more
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EASTBIO: The proteome social network: Characterizing cellular protein interaction networks using advanced mass spectrometry and deep learning
Proteins are building blocks of the body and the engines of life. They can be structural, like hair and skin, or mechanical, like machines that perform chemical transformations and tasks within cells. Read more
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Decoding the mechanism and function of UFMylation in ER Quality Control
Approximately one third of the human proteome depends on the endoplasmic reticulum (ER) for its biosynthesis. Read more
China Scholarship Council: Feel the tension – how does S-acylation of OSCA ion channels regulate responses to environmental change in plants?
Plants, being sessile organisms, must sense and respond to environmental change, such as temperature or drought, without being able to move. Read more