The project will explore new methods for medicinal chemistry optimisation for drug discovery using DNA-encoding. DNA-encoded approaches are established in the early (hit discovery) stage of drug discovery but their use in later stage optimisation is relatively unexplored. Read more
. PhD Study in Organic Synthesis and Medicinal Chemistry. The James McCune Smith PhD Scholarships will fund Black UK students to undertake PhD research at the University of Glasgow. Read more
Lead-like libraries provide ideal hits for drug discovery, but their construction usually relies on a common starting material, meaning that the libraries lack scaffold diversity. Read more
Funding provider. Engineering and Physical Sciences Research Council (EPSRC). Subject areas. Drug discovery / Medicinal chemistry/ Antivirals. Read more
The Farnaby group is pursuing an ambitious and exciting new programme to use induced proximity chemistry strategies for the development of Central Nervous System targeted chemical probes. Read more
Due to their value in pharmaceutical chemistry, innovative, efficient and low cost strategies to synthesis amine derivatives (including N-heterocycles) are required. Read more
This project aims to develop new photochemical synthetic methods that deliver increased efficiency and precision in the synthesis of spirocyclic sp3-rich molecules. Read more
Prostate cancer accounts for 375,000 deaths per year worldwide. Targeting the androgen receptor (AR) using hormone therapy is the mainstay treatment for advanced prostate cancer. Read more
Treatment of neurodegenerative disease needs new targets, as current approaches fail to translate in clinical trials. Elevated activation of the NLRP3 inflammasome coupled with activation of the NADase SARM1, have been implicated in early steps of neurodegeneration. Read more
Research project. We are seeking a highly motivated PhD candidate to join an interdisciplinary team at the University of Otago, to undertake research developing chemical probes for the cannabinoid receptor, a type of G protein-coupled receptor (GPCR). Read more
Overview. Interested in machine learning (ML) for molecular modelling? This PhD project will develop machine learning inter-atomic potentials (MLIPs) for molecular materials and organic-inorganic interfaces relevant to energy storage technology and medicinal applications. . Read more
Saarland University (UdS) is located in the Saarbrücken, Germany. The city is a state capital with 180.000 inhabitants, located between and well connected to Frankfurt, Paris, and Luxembourg. Read more
Neuropeptides are key mediators in many biological functions and understanding their interaction with target proteins is fundamental to unravel the underlying mechanism of diseases. Read more
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