Recent work suggests that cellular ageing, known as senescence, of endogenous stem-like cells in the brain may contribute to the chronic inflammation and neurodegeneration seen in people with progressive multiple sclerosis (PMS). Read more
Heterozygous mutations in HNF1B are the commonest genetic cause of human kidney malformations. Moreover, postnatally, kidney tubule physiology is deficient characterised by electrolyte (Mg2+ and K+)wasting into the urine. Read more
Background. The discovery of induced-pluripotent stem cells (iPSCs) has dramatically revolutionised our understanding of stem cell biology. Recently, 3D cultures have emerged as a significant advancement in regenerative medicine. Read more
Blood transfusions, bone marrow stem cell transplants, and immunotherapies are fundamental procedures in the treatment of malignant and non-malignant disorders. Read more
Project Overview. The Wilkinson research group focuses on the biology and translational applications of blood-forming haematopoietic stem cells (HSCs). Read more
Interested in exploring the untapped potential of stem cells in tissue regeneration and healing using cutting-edge interdisciplinary research techniques?. Read more
Project Overview. Functional interrogation of human gastrulation in bioprinted embryo models. How do complex body patterns emerge in the early embryo? The first signs of the human body axis can be traced back to the second week of gestation. Read more
Mitochondrial diseases are caused by defects in genes required for energy production and oxidative phosphorylation (OxPhos). We find it intriguing that some patients with mitochondrial disease present late in life, with very tissue-specific phenotypes. Read more
Project Overview. Some organisms, such as salamanders, retain a remarkable capacity for regeneration in various organs, which occurs through the process of epimorphic regeneration. Read more
This full-time DPhil post at the Botnar Institute will use cutting edge laboratory and computational methods to interrogate the mechanisms underlying failed repair following scaphoid fracture. Read more
About the project. Heart disease is a critical health burden and leading cause of mortality worldwide. To understand disease mechanisms and develop future treatments for heart disease, we have developed a human cardiac organoid platform derived from pluripotent stem cells. Read more
In order to ensure that a properly structured and functioning nervous system is produced the generation of neurons from stem cells must be carefully controlled. Read more
Background. Osteoarthritis (OA) is the most common arthritis, and a leading cause of disability globally. The primary feature of the disease is the breakdown of cartilage which covers the ends of the bones within the affected joint, known as articular cartilage. Read more
A 3-year PhD Studentship in Regenerative Medicine funded by the The Mosawi Foundation is available within the UCL Great Ormond Street Institute of Child Health. Read more
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