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We have 106 stem cells PhD Projects, Programmes & Scholarships for European Students (exc UK)
stem cells PhD Projects, Programmes & Scholarships for European Students (exc UK)
We have 106 stem cells PhD Projects, Programmes & Scholarships for European Students (exc UK)
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Maintaining human lung - the role of fibroblasts and lipids in alveolar regeneration
The human lung is built by more than 50 cell types, which cooperate to create a beautiful organ essential for us to breathe. Critically, lack of regenerative capacity is a key feature of many chronic lung diseases and ageing. Read more
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Establishment and Characterization of a Novel self-renewing, non-transformed Chicken Macrophage Cell Line for the Study of Innate Immunity
Background. Macrophages are a heterogeneous population of immune cells critical for host defense against pathogens. Tissue macrophages are embryonic derived self-renewing cells while bone marrow derived macrophages (BMDMs) are mostly inflammatory macrophages with a limited lifespan. Read more
EastBio: The mitotic tsunami: how cells re-build their identity in G1.
The Buonomo and Gilbert groups aim at building an understanding of the eukaryotic nuclear function that integrates knowledge from what are traditionally viewed as different fields, such as epigenetics, DNA replication and nuclear architecture. Read more
Building the first heart vessel
How does the heart form? Despite the large array of adult heart morphologies across nature, the initial heart tube typically forms as a simple tubular structure. Read more
Probing the establishment of genomic architecture after nuclear confinement
A key focus of the post-genomics era is the role of three-dimensional positioning on gene expression and genomic integrity. In the Bowman lab at Warwick Medical School we are interested in chromatin structure and function. Read more
Genetics: why and how do animals edit their own genomes?
In principle, all cells derived from a fertilised egg have the same genetic information. However, in some animals, specific genomic regions are removed from somatic cells during development. Read more
(Bicentenary) Development and validation of human lung organoids enriched with immune component to assess pulmonary effects of air pollution and micro/nanoplastics
Air pollution has already been linked to adverse human health effects (respiratory illness, cardiovascular disease, and carcinogenesis) in epidemiological studies. Read more
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Development of a Human Hepatocyte Culture System to Simultaneously Measure Drug-Induced Liver Injury and Determine the Hepatobiliary Elimination Transporter(s)
The Problem. Inhibition of bile flow by off target effects of therapeutic drugs is a significant clinical problem and such drug-induced liver injury (DILI) is the major cause of failure of drugs in human trials. Read more
Patient-derived Retinal Organoids for Modeling Uveitis: Developing a Humanized In Vitro Model in Ocular Inflammation Research
Uveitis, an immune-mediated inflammatory disease of the eye, represents a significant cause of visual impairment worldwide, accounting for 10-20% of blindness cases in developed nations and up to 25% in developing countries (1). Read more
(Bicentenary) Understanding Spinal Cord Regeneration: The Role of Dynamic Gene Expression
Spinal cord injury (SCI) paralysis is a devastating disease that increased from 2500 to 4400 in the last couple years in average in the UK. Read more
Identifying therapeutically-targetable mechanisms of PIK3CA mutant-specific signal transfer
The Madsen Lab is dedicated to a systems understanding of PI3K signalling plasticity, inspired by observations from human disorders such as cancer and PIK3CA-related overgrowth spectrum (PROS) 1,2. Read more
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The curious case of Turritopsisdohrni jellyfish – elucidating epigenetic principles of immortality
This project aims to explore the molecular mechanisms behind the biological immortality of Turritopsis dohrnii, commonly known as the 'immortal jellyfish.'… Read more
MRC DiMeN Doctoral Training Partnership: Investigating the role of novel motor protein in tendon development and aging.
Musculoskeletal ageing is a multifactorial process resulting in joint stiffness and progressive tissue degeneration. This project investigates tendon ageing using tissue engineering and primary cells obtained from a mouse model of human genetic condition characterised by early-onset tendinopathy and joint degeneration. Read more
EastBio: The role of epigenetic regulation in red blood cell development
Red blood cell differentiation (erythropoiesis) is an exquisitely orchestrated process that progressively promotes commitment and differentiation of hematopoietic stem cells, to generate highly specialized erythrocytes needed for oxygen transport. Read more
CASE: Generating epithelial differentiation models to explore impact of oral mucosal immunity on EBV replication
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus1 associated with the development of both lymphoid and epithelial tumours; and most recently, implicated in the development of autoimmune diseases such as MS, ME and long covid2. Read more