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University of Leeds, Faculty of Biological Sciences PhD Projects, Programs & Scholarships

We have 24 University of Leeds, Faculty of Biological Sciences PhD Projects, Programs & Scholarships

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  An integrated approach to the study of cellular interactions with amyloid
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr E W Hewitt, Prof S E Radford
Applications accepted all year round
The formation of insoluble amyloid fibrils is associated with a spectrum of human disorders, the amyloidoses, which include Alzheimer’s, Parkinson’s, type 2 diabetes and dialysis related amyloidosis (DRA).
  Characterization of bispecific antibodies using structural mass spectrometry and imaging techniques
  Research Group: Astbury Centre for Structural Molecular Biology
  Prof F. Sobott, Prof N A Ranson, Dr J.R. Ault
Application Deadline: 28 February 2019
The majority of drugs currently in development are biotherapeutics, i.e. based on proteins, antibodies or other biomolecules. They promise unsurpassed specificity and selectivity in how they target molecules or structures in the cell, but can also carry cargo to their destination.
  Development and characterisation of synthetic ion channel binding proteins.
  Research Group: School of Biomedical Sciences
  Dr J D Lippiat, Dr D Tomlinson
Applications accepted all year round
We are developing methods to identify novel proteins, Affimers, that recognise extracellular domains of ion channels. These have applications in various aspects of biology, from tools to visualise the location and distribution of ion channels in native tissue, to novel modulators of ion channel function.
  Dissecting the molecular mechanisms of antibiotic resistance in bacterial pathogens
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr A O'Neill
Applications accepted all year round
Antibiotics make possible the treatment and cure of life-threatening bacterial infections. Since their introduction in the middle years of the 20th Century, they have added ~10 years to the human lifespan, and have become a cornerstone of modern medicine.
  Dynamics of motivation in physical activity and health behaviours
  Research Group: School of Biomedical Sciences
  Dr A Divine, Dr S Burke
Application Deadline: 11 March 2019
Physical inactivity is a significant and growing healthcare burden, as such, strategies for effective interventions and initiatives are necessary.
  Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas
  Research Group: School of Molecular and Cellular Biology
  Dr J Boyes
Applications accepted all year round
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas.
  Epigenetics and Cancer: Development of Novel Tools to Determine how Aberrant V(D)J Recombination Reactions Cause Leukaemia
  Dr J Boyes
Applications accepted all year round
V(D)J recombination generates a highly diverse set of immunoglobulin and T cell receptor genes to enable vertebrates to fight a vast range of infections.
  Genomic basis of extra-group paternity in the cooperatively breeding Seychelles warbler
  Dr H L Dugdale
Applications accepted all year round
Indirect genetic benefits are hypothesised to drive the evolution of extra-group paternity (EGP), yet its genomic basis is unknown.
  Healthy ageing and diaphragm dysfunction: neuromuscular causes and implications for exercise tolerance.
  Research Group: School of Biomedical Sciences
  Dr B Taylor, Dr C Ferguson, Dr T.S. Bowen
Application Deadline: 11 March 2019
Normal ageing of the respiratory system involves significant and negative structural changes to the lungs, airways, and respiratory muscles.
  Identifying cardiac disease markers using non-lethal ’biopsy’ of cells.
  Research Group: School of Biomedical Sciences
  Dr A.J. Smith
Applications accepted all year round
This project will build on our recent exciting discovery that a novel chemical tool, the polymer styrene maleic acid (SMA), can ‘biopsy’ human vascular cells, extracting proteins from the membrane without killing the cells.
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