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University of Leeds, Faculty of Biological Sciences PhD Projects, Programs & Scholarships

We have 45 University of Leeds, Faculty of Biological Sciences PhD Projects, Programs & Scholarships

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Faculty of Biological Sciences  University of Leeds

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We have 45 University of Leeds, Faculty of Biological Sciences PhD Projects, Programs & Scholarships

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Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

  Research Group: School of Molecular and Cellular Biology
V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves the breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Life and Death Dilemma: Controlling endoplasmic reticulum stress

One of the most ubiquitous signaling pathways in the eukaryotic cells is the unfolded stress response (UPR). UPR is crucial for cell survival through enabling real-time adaptive adjustments of the folding capacity in the endoplasmic reticulum (ER). Read more

Using Dynamic Combinatorial Selection Methods to Identify Chemical Modifications of Protein Function

Intrinsically disordered regions (IDRs), are ubiquitous stretches of protein that do not adopt a stable structure, are a major class of protein structure found in all living organisms, and, are predicted to be present in around a third of eukaryotic proteins. Read more

Understanding the dynamics of non-ribosomal peptide synthetases

Non-ribosomal peptide synthetases are dynamic molecular machines which produce some of the most important medicinal compounds including the antibiotic vancomycin, the immunosuppressant rapamycin and the anticancer agent Bleomycin. Read more

Deciphering the glycocode: application of synthetic probes to study protein-carbohydrate interactions

All living cells are covered in a coating of complex carbohydrates (glycans) that are attached to lipids and proteins. Specific glycolipids play important roles in controlling cell differentiation, ion transport and cell signaling. Read more

Developing methods for Cryo-EM using Affimers to understand blood clotting

This studentship provides world class training in cryo-EM, molecular biology and protein biochemistry. The project will focus on developing cryo-EM methods to characterise proteins to understand the clotting process, a leading cause of morbidity. Read more

Molecular footprints of protein crowding and aggregation in vivo

Proteins are molecular workhorses of the cell, and understanding structures and details of their interactions with other molecules is essential to understand normal function, identify disease mechanisms and uncover new targets for therapies. Read more

Understanding how myosin regulation regulates cell behaviour

Myosin misbehaving. Myosins are motor proteins important for many diverse functions from muscle contraction to cell migration, organelle trafficking and organisation of the actin cytoskeleton in non-muscle cells. Read more

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