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The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programs & Scholarships

We have 340 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programs & Scholarships

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Faculty of Biology, Medicine and Health  The University of Manchester

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We have 340 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programs & Scholarships

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(MRC DTP) Characterisation of longitudinal peripheral immune cellular changes in vascular dementia

Stroke is a major cause of death and disability worldwide. In stroke survivors one of the most distressing complications is dementia, which occurs in up to a third of individuals within five years and impacts significantly on quality of life. Read more

(BBSRC DTP) A synthetic vaccine against the parasitic worm Schistosoma mansoni

Schistosomiasis is an infection caused by a parasitic blood flook, Schistosoma. Approximately 260 million people are estimated to carry the infection, mainly concentrated in low income countries, causing high levels of morbidity and mortality. Read more

(BBSRC DTP) Dynamics of neurogenesis during spinal cord regeneration

About 1200 people a year are left paralysed in the UK due to a Spinal Cord Injury (or SCI). This is because injuries involving the central nervous system (CNS) have poor capacity to repair or regenerate, thus resulting in a permanent loss of function. Read more

(BBSRC DTP) Omics approaches to study Receptor Tyrosine Kinase functional selectivity in complex environment

The outside environment influences cells’ decision of whether to proliferate or move through the activation of Receptor Tyrosine Kinase (RTK) signalling downstream of growth factors. How different growth factors binding to the same RTK generates specific long-term outputs - known as functional selectivity1 - is unknown. Read more

(BBSRC DTP) Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

(BBSRC DTP) Hormonal regulation of mast cell activity

Oestrogen levels fluctuate throughout life, impacting tissue function during menses, pregnancy and menopause. Oestrogen greatly affects immune responses, often enhancing the activities of both the innate and adaptive immune system. Read more

(BBSRC DTP) Defining the roles of mRNA methylation in circadian physiology and inflammation

Methylation is a pervasive biochemical modification targeting virtually all types of molecules in our cells. A key metabolic pathway called the “methyl cycle” synthesises S-adenosylmethionine (SAM), the methyl donor co-substrate used by over 200 substrate-specific methyltransferases described so far in humans. Read more

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