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The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programs & Scholarships

We have 336 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programs & Scholarships

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  (BBSRC DTP CASE) Analysing the efficiency of protein secretion using Lattice Lightsheet Microscopy
  Prof V Allan, Prof M Lowe, Prof S Cartmell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein-based biopharmaceuticals are of tremendous importance both for providing disease treatments, and for the UK economy. They are typically manufactured using mammalian host cells, but some are much harder to produce than others.
  (BBSRC DTP CASE) Identification of cell types and subtypes within tissues by mass spectrometry imaging
  Dr A McMahon, Prof K Williams, Dr N Thacker
Application Deadline: 31 January 2020

Funding Type

PhD Type

This project will bring together the capabilities of the University’s Imaging research group, and the extensive mass spectrometry imaging facilities of the Medicine Discovery Catapult at Alderley Park, at Waters at their Wilmslow site and using a DESI-imaging mass spectrometer, placed by Waters, at the University.
  (BBSRC DTP CASE) Jellyfish-collagen hydrogels for culture and differentiation of human mesenchymal stem cells and 3D cartilage bioprinting
  Dr J Bella, Dr S Richardson, Dr M Domingos
Application Deadline: 31 January 2020

Funding Type

PhD Type

We are looking for an enthusiastic and talented graduate from a relevant biomedical or materials science degree to develop next-generation, sustainable collagen-based scaffolds for stem cell culture, differentiation, and 3D bioprinting, aimed at tissue regeneration applications.
  (BBSRC DTP CASE) Understanding and predicting the immunogenicity of therapeutic protein products
  Prof J P Derrick, Dr R Dearman
Application Deadline: 31 January 2020

Funding Type

PhD Type

Biopharmaceuticals, or therapeutic protein products (TPPs) have been in widespread clinical use for several decades. They comprise a wide range of pharmaceutical products, from vaccines to hormones, cytokines and monoclonal antibodies.
  (BBSRC DTP CASE) Use of genomic technologies to enhance food safety and authenticity
  Dr M Bromley, Prof P Bower
Application Deadline: 31 January 2020

Funding Type

PhD Type

The annual cost to UK health service due to food related ill health is £6Bn. In addition food fraud is estimated to cost UK business in the region of £11 Bn per annum.
  (BBSRC DTP) A moving account of degradation: receptor signalling, endosomes and motor proteins
  Prof P Woodman, Prof V Allan, Prof M Lowe
Application Deadline: 31 January 2020

Funding Type

PhD Type

Endosomes are hubs for regulating multiple signaling pathways, because endosomal sorting determines the fate of cell surface signalling receptors.
  (BBSRC DTP) Brain integration and processing of ingestive signals
  Prof S Luckman, Dr G D'Agostino
Application Deadline: 31 January 2020

Funding Type

PhD Type

After meal consumption, the brain evaluates the value of its contents and relays this information via neuronal circuits connecting the periphery with the brain (1,2).
  (BBSRC DTP) Cardiac Physiology in the World’s Oldest Vertebrate, The Greenland Shark
  Dr H Shiels, Dr G Galli
Application Deadline: 31 January 2020

Funding Type

PhD Type

The life span of the Greenland shark is at least 272 years and may be as long as 500 years making this animal the longest living vertebrate on the planet1.
  (BBSRC DTP) Characterising the proteolytic network of plant cathepsin B
  Dr P Gallois, Dr A Day
Application Deadline: 31 January 2020

Funding Type

PhD Type

Programmed Cell Death (PCD) is a process that is critical to all organisms for development and defence against pathogens. The process of PCD in plants does not mirror what has been described in animal apoptosis and represents a novel alternative pathway still to be fully discovered.
  (BBSRC DTP) Complexity of heart development arising from evolution of signalling systems
  Dr K Hentges, Dr D Talavera, Prof S Lovell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Protein families grow or shrink in size during evolution due to gene duplication and gene loss events. These events provide opportunities for protein function specialisation or innovation.
  (BBSRC DTP) Cytoskeletal re-arrangements leading to correct neuron polarisation during vertebrate CNS development
  Dr R Das, Prof V Allan, Dr S Herbert
Application Deadline: 31 January 2020

Funding Type

PhD Type

Background. Neuronal differentiation during embryonic development is a fundamentally important process that ultimately results in the formation of functional neural circuitry.
  (BBSRC DTP) Definition of integrin signalling networks in neurons in vivo
  Prof A Prokop, Prof M J Humphries
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cell adhesion molecules (CAMs) of the plasma membrane physically tie cells together into tissues, both via interaction of cells with other cells or with ECM (extracellular matrix); they also constitute hubs of information exchange with neighbouring cells and the environment.
  (BBSRC DTP) Definition of the force-sensitive mechanisms linking the plasma membrane to the nucleus using proximity biotinylation-based proteomics
  Prof M J Humphries, Dr J Swift
Application Deadline: 31 January 2020

Funding Type

PhD Type

The behaviour of cells is determined by how they interpret their genetic and epigenetic programming in the context of signals from their surroundings.
  (BBSRC DTP) Developing a whipworm vaccine composed of virus-like particles expressing Trichuris T cell epitopes
  Prof K Else, Prof J P Derrick
Application Deadline: 31 January 2020

Funding Type

PhD Type

Vaccination is one of the greatest advances in global health; however most successful vaccines have been made empirically. We still have little insight into how many vaccines work and the mechanisms by which they trigger protective immune responses.
  (BBSRC DTP) Epigenetic mechanisms of behavioural, placental and cognitive impairment in a neurodevelopmental model for schizophrenia
  Dr R Hager, Prof J Neill, Dr J Glazier
Application Deadline: 31 January 2020

Funding Type

PhD Type

A fundamental unknown in understanding mechanisms of disease, and therefore improving therapy, is how stressors experienced during critical developmental periods influence the genesis or ‘programming’ of adult disease (Estes & McAllister 2016).
  (BBSRC DTP) Examining the neural pathways controlling human swallowing in the older brain through cortical and peripheral neurostimulation
  Prof S Hamdy, Prof R Elliott
Application Deadline: 31 January 2020

Funding Type

PhD Type

The ageing process involves physiological and neurological changes that diminish swallowing safety and efficiency, which may increase the risk of life-threatening complications such as malnutrition and aspiration pneumonia.
  (BBSRC DTP) Exploiting transcriptional regulation to improve plant cell wall as a feedstock for the sustainable production of biofuels and other chemicals
  Prof S Turner, Dr M Kim, Prof A Sharrocks
Application Deadline: 31 January 2020

Funding Type

PhD Type

Cellulose is a polymer of glucose and its remarkable structural properties means it is the world’s most abundant biopolymer. Cellulose from higher plants is an abundant source of renewable material that can be used as a source of raw material for chemical and fuel production, or for generating novel biomaterials.
  (BBSRC DTP) Exploring the developing microbiome in new-born babies
  Dr S Cruickshank, Prof A McBain, Dr C Knight
Application Deadline: 31 January 2020

Funding Type

PhD Type

The gut microbiome contains a large diverse community of microorganisms with our bacteria being best understood. These bacteria play crucial roles for our health such as aiding in the digestion of food, production of key vitamins and metabolites and programming out immune system.
  (BBSRC DTP) Exploring the host-microbiome interactions to promote healthy skin function
  Prof A Nicolaou, Prof A McBain, Prof C A O'Neill, Dr A Kendall
Application Deadline: 31 January 2020

Funding Type

PhD Type

The surface of our skin is an intriguing landscape covered by a diverse population of microorganisms that are collectively known as the cutaneous ‘microbiome’.
  (BBSRC DTP) From mucin biochemistry to pulmonary immunity: How do mucins promote antimicrobial lung defences?
  Prof E Bignell, Prof D Thornton, Dr A Horsley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Respiratory mucus plays multiple essential roles in mammalian lung function, from hydrating the epithelium and supporting gaseous exchange, to expelling inhaled particles and microbes and providing a conduit for innate and adaptive immune signaling.
  (BBSRC DTP) Functional and structural analysis of RBBP5: a histone tail modifier essential for development, disease and healthy ageing
  Dr G Poulin, Prof A Sharrocks, Dr A J Whitmarsh
Application Deadline: 31 January 2020

Funding Type

PhD Type

The genome is the blueprint of any living system. However, it is the regulation of gene expression that enables life. For transcription to take place, the molecular machinery involved has to access genomic DNA.
  (BBSRC DTP) How is our head formed? – alx1 homeobox gene and craniofacial development
  Dr S Herbert, Dr T Takahashi, Prof M Rattray
Application Deadline: 31 January 2020

Funding Type

PhD Type

The recent technological advancement of bioinformatics, next-generation sequencing and live imaging has transformed medical research.
  (BBSRC DTP) Improving 3D X-ray Imaging of Live Cells and Soft Tissues
  Dr M Sherratt, Prof S Cartmell
Application Deadline: 31 January 2020

Funding Type

PhD Type

Clinical X-ray imaging in three dimensions (commonly referred to as a CT scan) is a key diagnostic tool. Micro-computed X-ray tomography (microCT) has the potential to image relatively large biological samples in 3D at sub-micron resolution.
  (BBSRC DTP) Integrative statistical inference methods for eukaryotic gene regulation with applications to embryonic stem cell differentiation
  Dr I Iqbal, Prof M Rattray, Prof A Sharrocks
Application Deadline: 31 January 2020

Funding Type

PhD Type

Embryonic stem cells (ESCs) can differentiate into different cell types through intermediary cell states and deeper understanding of the regulatory control underlying these differentiation stages is a very important topic in the study of mammalian development (Yang et al., 2014 & 2019).
  (BBSRC DTP) Kinesin light chains: why so many?
  Prof V Allan, Prof M Ashe, Dr G Poulin
Application Deadline: 31 January 2020

Funding Type

PhD Type

Kinesin-1 is a microtubule motor that moves many cargoes within cells, and this transport is crucial for life and health.
  (BBSRC DTP) Light-dependent control of physiology via the brain’s central clock
  Dr T Brown, Dr D Bechtold, Dr G D'Agostino
Application Deadline: 31 January 2020

Funding Type

PhD Type

Aside from helping us perceive the world around us, light is a key regulator of physiology and behaviour due to its influence on the brains internal clock in the suprachiasmatic nuclei (SCN).
  (BBSRC DTP) Mapping Notch endocytic signalling pathways via quantitative proteomics in Drosophila melanogaster
  Prof S Hubbard, Dr M Baron, Prof C Mills
Application Deadline: 31 January 2020

Funding Type

PhD Type

Extracellular signalling allows cells to communicate with one another in the context of tissues and influence the fate of their neighbouring cells, transducing signals from the external environment to the nucleus to affect the expression of target genes.
  (BBSRC DTP) Mapping Notch trafficking using immunofluorescence and computer vision
  Dr N Thacker, Dr M Baron, Dr P Bromiley
Application Deadline: 31 January 2020

Funding Type

PhD Type

The functional regulation of proteins in cells is strongly related to their spatial distributions. This is particularly true of signalling proteins, which may be switched on and off by transfer between different locations.
  (BBSRC DTP) Mechanism of early steps in protein synthesis by cryoEM imaging of supramolecular complexes
  Dr A Roseman, Prof G D Pavitt, Prof C Baldock
Application Deadline: 31 January 2020

Funding Type

PhD Type

The aim of this project is to understand the mechanism and control of protein synthesis in eukaryotic cells at the molecular level, particularly focused around the role of the eukaryotic translation initiation factors eIF2, eIF5 and eIF2B.
  (BBSRC DTP) Metals and bacterial virulence: overcoming metal intoxication during infection
  Dr J Cavet, Dr D Linton, Prof J Lloyd
Application Deadline: 31 January 2020

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen, being the leading bacterial cause of human acute gastroenteritis and responsible for an estimated 0.5 billion cases each year.
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