We have 94 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programmes & Scholarships

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

Supervisors: Dr N.V.R Van Rhijn, Dr M Bromley

Year round applications PhD Research Project Self-Funded PhD Students Only

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Modelling the ecology and evolution of microbial communities

The University of Manchester Faculty of Biology, Medicine and Health

From the human gut to deep-sea sediments, microbial communities – or microbiomes – colonize virtually every habitat on earth. These microbiomes are central to ecosystem functioning and to host health, and therefore it is essential that we understand how and why they change over time. Read more

Supervisors: Dr K Coyte, Dr C Knight

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Investigating the connection between early embryo architecture and embryo viability

The University of Manchester Faculty of Biology, Medicine and Health

Include details on the project, outlining the objectives, methods and potential outcomes. Include details of training/techniques to be provided. Read more

Supervisors: Dr B Plusa, Dr K Dorey

Year round applications PhD Research Project Self-Funded PhD Students Only

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The circadian clock as a regulator of information processing

The University of Manchester Faculty of Biology, Medicine and Health

Endogenous biological clocks are a ubiquitous feature of living organisms, driving rhythms in countless cellular and physiological functions, and influencing almost all biological processes. Read more

Supervisors: Dr A Allen, Prof R Lucas

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Investigating WSB-1 as a prognostic marker and therapeutic target in urogenital cancers

The University of Manchester Faculty of Biology, Medicine and Health

Prostate cancer (PCa) is the commonest cancer diagnosed in men, with 5-year survival rates of 60% in those with advanced disease. Read more

Supervisors: Dr IP Monteiro dos Santos Pires, Prof AC Choudhury

Year round applications PhD Research Project Self-Funded PhD Students Only

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Control of gene expression in embryonic development

The University of Manchester Faculty of Biology, Medicine and Health

The impressive range of anatomical variations observed in animals along their body axis is the result of distinct control mechanisms governing gene expression. Read more

Supervisors: Prof N Bobola, Dr M Birket

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating immune contributions to frontotemporal dementia and motor neuron disease

The University of Manchester Faculty of Biology, Medicine and Health

Frontotemporal dementia (FTD) is the 2nd most common form of dementia affecting younger people, with a typical age of onset in the mid-late 50s. Read more

Supervisors: Dr SR Ryan, Prof D Brough

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating the genetic basis of immunological overlap between inflammatory diseases

The University of Manchester Faculty of Biology, Medicine and Health

Genetic studies have identified numerous variants within the human genome associated with susceptibility to common complex inflammatory diseases, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). Read more

Supervisors: Mr P Martin, Prof S Eyre, Prof A Morris

Year round applications PhD Research Project Self-Funded PhD Students Only

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A deep-learning approach to genomic regulation of tissue-specific alternative splicing

The University of Manchester Faculty of Biology, Medicine and Health

Each human gene is a blueprint for multiple distinct RNA transcripts that can be produced in differing quantities based on the localisation of the transcribing… Read more

Supervisors: Dr JE Eales, Prof T Papamarkou

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of how pro-peptide regions of collagen control extracellular matrix homeostasis, in health and musculoskeletal diseases

The University of Manchester Faculty of Biology, Medicine and Health

Collagen-I (‘collagen’ from hereon) is the most abundant protein in the human body (circa 25% of total protein mass), providing structure to organs with very different functions (e.g. Read more

Supervisors: Dr JC Chang, Dr TZ Zacharchenko, Prof C Baldock

Year round applications PhD Research Project Self-Funded PhD Students Only

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Clinical Prediction Modelling under Federated Learning

The University of Manchester Faculty of Biology, Medicine and Health

Clinical prediction models (CPMs) take a set of characteristics about a patient to estimate their risk of an event of interest. Developing CPMs using data that captures observations across multiple clusters (e.g., countries) can increase the robustness and generalisability of CPMs. Read more

Supervisors: Dr G P Martin, Dr M Sperrin, Dr DJ Jenkins

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Identifying critical pathways regulating autoimmunity in immuno-oncology and arthritis patients. Short title: IPADS (Immune PAthways for Drug Side-effects)

The University of Manchester Faculty of Biology, Medicine and Health

Inflammatory arthritis (IA) can result from non-autoimmune diseases (like crystal arthritis) and from autoimmune diseases like rheumatoid arthritis (RA) and spondyloarthropathies (inc. Read more

Supervisors: Dr S Viatte, Prof A Barton, Mr P Martin

Year round applications PhD Research Project Self-Funded PhD Students Only

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The role of nuclear localisation of adhesion proteins in tumour growth and invasion

The University of Manchester Faculty of Biology, Medicine and Health

Overview. This project seeks to understand how tumour growth and invasion are controlled by the localisation of certain proteins in cancer cells. Read more

Supervisors: Dr AB Byron, Dr K Finegan, Dr C Tournier

Year round applications PhD Research Project Self-Funded PhD Students Only

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Nitrate supplementation in pregnancy: maternal, fetal and offspring outcomes

The University of Manchester Faculty of Biology, Medicine and Health

Maternal diet has a significant impact on fetal growth and development, as well as pregnancy outcomes and long-term offspring health. Dietary patterns… Read more

Supervisors: Dr E Cottrell, Dr M Dilworth

Year round applications PhD Research Project Self-Funded PhD Students Only

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Understanding Spinal Cord Regeneration: The role of dynamic gene expression

The University of Manchester Faculty of Biology, Medicine and Health

Spinal cord injury(SCI) paralysis is a devastating disease that affects at least 2500 people per year in the UK. It carries substantial individual and societal costs with most SCI sufferers experiencing chronic pain. Read more

Supervisors: Dr X Soto Rodriguez, Dr K Dorey, Dr Cerys Manning

Year round applications PhD Research Project Self-Funded PhD Students Only

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Defining the molecular mechanisms of leukaemia chemotherapies

The University of Manchester Faculty of Biology, Medicine and Health

Chemotherapies are usually the backbone of cancer treatment for either curative or palliative patient care. Multiple therapies can be used for the same disease, with the choice of drug dependent on parameters such as the patient’s age and fitness. Read more

Supervisors: Dr JK Knight, Dr K Batta, Dr D Wiseman

Year round applications PhD Research Project Self-Funded PhD Students Only

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Characterisation of PA protease from Micrococcus luteus as a novel approach to the management of eczema

The University of Manchester Faculty of Biology, Medicine and Health

The chronic inflammatory skin disease, eczema, now affects approximately 15% of the paediatric population of the Western world and is growing in prevalence. Read more

Supervisors: Prof CN O'neill, Prof A McBain

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Imagery in Action in Parkinson’s disease

The University of Manchester Faculty of Biology, Medicine and Health

Parkinson’s disease is a neurodegenerative condition affecting around 1 in 500 people, with significant impact on movements, which are typically slower and smaller. Read more

Supervisors: Dr E Poliakoff, Dr E Gowen

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Communication and co-speech gestures in Parkinson’s disease

The University of Manchester Faculty of Biology, Medicine and Health

Parkinson’s disease is a neurodegenerative condition affecting around 1 in 500 people, with significant impact on movements and quality of life. Read more

Supervisors: Dr E Poliakoff, Dr P Conroy

Year round applications PhD Research Project Self-Funded PhD Students Only

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Chaperones and the response to protein misfolding stress

The University of Manchester Faculty of Biology, Medicine and Health

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more

Supervisors: Prof C M Grant, Prof M Ashe

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Investigating the interaction of La related proteins with colliding ribosomes

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process for all life. This requires ribosomes to act with an array of translation factors to decode mRNA sequences. Read more

Supervisors: Prof G D Pavitt, Dr A Roseman

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Graphene oxide as growth factor carriers for meniscus tissue engineering

The University of Manchester Faculty of Biology, Medicine and Health

Damage to the meniscus of the knee leads to increased risk of osteoarthritis. Tissue engineering of a healthy meniscal fibrocartilage offers the opportunity to restore function. Read more

Supervisors: Dr H Lu, Dr S Richardson, Prof P Xiao

Year round applications PhD Research Project Self-Funded PhD Students Only

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Model-predictive control of brain plasticity for optimal non-invasive brain stimulation

The University of Manchester Faculty of Biology, Medicine and Health

Neuroplasticity is the mechanism that underpins the brain’s ability to learn or recovery from traumatic events, but also its deterioration underlies several Neurodegenerative diseases and mental illnesses. Read more

Supervisors: Dr N Trujillo-Barreto, Dr C Lea-Carnall

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Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni

The University of Manchester Faculty of Biology, Medicine and Health

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year. Read more

Supervisors: Dr J Cavet, Dr D Linton

Year round applications PhD Research Project Self-Funded PhD Students Only

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Identification of transcriptomic signatures of autism-like neurodevelopmental disorder

The University of Manchester Faculty of Biology, Medicine and Health

The overarching aim of this project is to define transcriptional patterns and identify new genetic elements essential for the correct development of the human brain. Read more

Supervisors: Dr PG Grzechnik, Dr A J Whitmarsh

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Full exploitation of amyloid PET-MR data for dementia research

The University of Manchester Faculty of Biology, Medicine and Health

Simultaneous PET-MR data acquisition using amyloid radiotracers has utility for future clinical studies such as the development of novel therapeutic interventions for dementia. Read more

Supervisors: Dr M Asselin, Dr J Matthews, Dr L Parkes

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Determining how immune responses are regulated in the lung and gut by the local environment

The University of Manchester Faculty of Biology, Medicine and Health

The immune system must respond quickly to infection but must also be tightly regulated so it ignores harmless substances and our own tissues. Read more

Supervisors: Prof M Travis, Prof R K Grencis, Prof D Thornton

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Adverse Events to Methotrexate in Inflammatory Arthritis: Does Age Matter?

The University of Manchester Faculty of Biology, Medicine and Health

A consistent top-5 research priority for both children and adults with inflammatory arthritis is the tailoring of treatments to prevent or lessen adverse events. Read more

Supervisors: Dr S Shoop-Worrall, Prof K Hyrich, Dr S Verstappen

Year round applications PhD Research Project Self-Funded PhD Students Only

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Circadian mechanisms in psoriasis: therapeutic opportunities

The University of Manchester Faculty of Biology, Medicine and Health

Hallmark features of psoriasis symptoms vary through time, suggesting an important role for circadian circuits in driving disease expression, and offering the potential of chronotherapy. Read more

Supervisors: Dr H Young, Dr I Iqbal, Prof D Ray

Year round applications PhD Research Project Self-Funded PhD Students Only

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Investigating monogenic disorders of the protein synthesis machinery

The University of Manchester Faculty of Biology, Medicine and Health

Translation of mRNA into proteins is a critical cellular biological process. We recently described a novel human disorder, now called Faundes-Banka Syndrome (FABAS), caused by heterozygous variants in EIF5A1 that encodes a translation factor. Read more

Supervisors: Dr P Kasher, Dr S Banka, Prof G D Pavitt

Year round applications PhD Research Project Self-Funded PhD Students Only

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We have 94 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programmes & Scholarships

The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programmes & Scholarships

We have 94 The University of Manchester, Faculty of Biology, Medicine and Health PhD Projects, Programmes & Scholarships

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