We have 43 University of Bradford, Faculty of Life Sciences PhD Projects, Programmes & Scholarships
University of Bradford, Faculty of Life Sciences PhD Projects, Programmes & Scholarships
We have 43 University of Bradford, Faculty of Life Sciences PhD Projects, Programmes & Scholarships
A bifunctional prodrug to overcome acquired oxaliplatin drug resistance in colorectal cancer
Research Group:
Institute of Cancer Therapeutics
This is one of two new fully funded PhD studentships in the Institute of Cancer Therapeutics Doctoral Training Centre (ICT-DTC) at the University of Bradford. Read more
Rational Control of Crystal Morphology
Research Group:
Chemistry and Biosciences
The external shape of crystalline particles (called morphology) is of paramount importance in a wide range of applications, in particular pharmaceuticals and pigments. Read more
Directed Co-Crystallisation of Pharmaceuticals: developing a predictive method for co-crystallisation
Research Group:
Chemistry and Biosciences
In this project, we propose to use a combination of computational and experimental techniques to develop a predictive method for co-crystallisation. Read more
Oxidic Nanomaterials for High Density Storage in Li-ion Batteries
Research Group:
Chemistry and Biosciences
The oxides of a number of materials are very appealing candidates as substitutes for conventional anodes in lithium-ion batteries because of their high theoretical capacity, high electric conductivity low potential of lithium ion intercalation, as well as superior electron mobilities, with one such material, SnO2 being particularly appealing. Read more
Nanomaterials as White Light Emitters for Low Cost Lighting
Research Group:
Chemistry and Biosciences
White-light emission (WLE) from semiconductor nanostructures is presently a research area of intense interest especially where the primary objective is to replace conventional light sources by environmentally friendly materials in order to minimize energy costs and therefore the global energy consumption for lighting. Read more
Core and core-shell nanomaterials synthesis for Optoelectronics
Research Group:
Chemistry and Biosciences
Nanoscience and technology, which involves the manipulation of materials using the property of size to bring about specific desired changes in the electronic structure of materials, has proven to be a powerful additional tool permitting the materials scientist to effect greater control over the charge transport properties in materials. Read more
Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
Research Group:
Institute of Cancer Therapeutics
Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working. Read more
Polysialyltransferases as a target in metastatic cancer
Research Group:
Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases. Read more
Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
Research Group:
Institute of Cancer Therapeutics
Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis. Read more
Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
Research Group:
Institute of Cancer Therapeutics
Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs). Read more
Pharmacokinetics Guided Natural Products Exploration for Drug Discovery, Development, Delivery and Therapy
Research Group:
Institute of Cancer Therapeutics
Natural products have emerged as a key standard in novel and safe delivery of anticancer bioactive compounds. Apart from their ease of administration and delivery, natural/phytochemicals still face several hurdles, due to their physiochemical and pharmacokinetic properties. Read more
ERK5 MAPK signalling in Alzheimer’s disease
Research Group:
Pharmacology and Experimental Therapeutics
Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available. Read more
Investigation of antagonism of multiple RGD-binding integrins as a therapeutic strategy in advanced head and neck cancer
Research Group:
Institute of Cancer Therapeutics
Background. The integrins are a family of transmembrane receptors which mediate cell-cell and cell-ECM adhesion, and signalling across the cell membrane involved in pathways controlling cell migration, proliferation, differentiation, cell survival and apoptosis. Read more
Nanoparticle synthesis and application in magnetic field hyperthermia for cancer therapy
Research Group:
Chemistry and Biosciences
Magnetic field hyperthermia (MFH) is currently undergoing clinical trials for use in humans. The research to date has shown the effectiveness of the approach in cells and animal models and the initial results from human trials are promising. Read more
Analysis of Magnetically Susceptible Nanoparticles via confocal and fluorescence spectroscopy
Research Group:
Chemistry and Biosciences
A project is requested for a student to design a device capable of studying medically targeted nanoparticles (with potential applications in cancer therapy) under both microscopic and fluorescence devices. Read more