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University of Bradford, Faculty of Life Sciences PhD Projects, Programs & Scholarships

We have 49 University of Bradford, Faculty of Life Sciences PhD Projects, Programs & Scholarships

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  Aldehyde dehydrogenase expression and function in cancer stem cells
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr A Mardaryev, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Aldehyde dehydrogenases (ALDHs) catalyse the oxidation and detoxification of reactive endogenous and exogenous aldehydes into carboxylic acids via NAD+ coupled reduction.
  An assessment of professional burnout within the pharmacist profession: A comparative study of Kuwait and the UK
  Research Group: Medicines Optimisation
  Dr L Breen, Dr B Fylan
Applications accepted all year round

Funding Type

PhD Type

Depression or nervous breakdown were originally used to express professional exhaustion resulted from stress until the 1970s when Freudenberger introduced burnout as a clinical complex to replace those terms (Felton, 1998).
  An investigation into the effect of team-based learning (TBL) on the development of professionalism in pharmacy students
  Research Group: Education Innovation Research and Development
  Dr G Quinn, Dr S Jones, Dr S Twedell
Applications accepted all year round

Funding Type

PhD Type

In 2015 the General Pharmaceutical Council reviewed its Standards of Conduct, Ethics and Performance, aiming to ensure that patients and others are “confident that they are receiving care from professionals who are wholly focused on delivering patient-centred care” (GPhC, 2015).
  Biodegradable composite materials (Bio-PolyMOFs) for applications in targeted delivery of drugs to improve healthcare and reduce antimicrobial resistance in developing countries and worldwide
  Research Group: Chemistry and Biosciences
  Dr S Nayak, Dr A L Kelly, Dr M Katsikogianni
Applications accepted all year round

Funding Type

PhD Type

Growing antimicrobial resistance (AMR) is one of the major global challenges and is linked to the use of unnecessarily high doses of orally administered antibiotics following medical surgery and infections.
  Biofilm disruption as an initial step in a novel strategy for treatment of chronic wounds based on multi-functional liposomal nanocarriers
  Research Group: Medicines Development and Pharmaceutical Sciences
  Dr X Liu, Dr S Shnyder, Dr C Chang
Applications accepted all year round

Funding Type

PhD Type

The cost to the NHS of caring for patients with chronic wounds is conservatively estimated to be £4.5-5.7bn/year, or around 4% of the total expenditure on health.
  Biomarkers of Genotoxic and Reprotoxic Effects after chemical exposure in vitro in human cells
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

In human monitoring procedures, measurements obtained from endpoints to determine genetic damage are sometimes referred to as biomarkers.
  Building scholarly communities of practice with an active and collaborative learning pedagogy (team-based learning (TBL))
  Research Group: Education Innovation Research and Development
  Dr G Quinn, Dr S Twedell
Applications accepted all year round

Funding Type

PhD Type

A ‘Community of Practice’ is a group of people who share a passion for something they do and learn how to do it better as they interact regularly.
  Chronic Wounds and Infection - impact on diabetic patients
  Research Group: Centre for Skin Sciences
  Dr M J Thornton, Dr J N Fletcher
Applications accepted all year round

Funding Type

PhD Type

Non-healing chronic wounds present a significant clinical challenge. In Europe, the cost of wound management accounts for 2%–4% of the health care budget and the complications associated with impaired wound healing can have a significant, long-term effect on the morbidity, mortality, and quality of life for patients.
  Computation and Confirmation Experiments on Solvated Hydrogen Bonding Complexes
  Research Group: Chemistry and Biosciences
  Dr T Swift, Dr C Seaton
Applications accepted all year round

Funding Type

PhD Type

The creation of complexes between polymeric compounds drives many industrial / biological processes and has been extensively studied in well-defined biological compounds with uniform structures.
  Core and core-shell nanomaterials synthesis for Optoelectronics
  Research Group: Chemistry and Biosciences
  Dr S Hickey, Dr W Martin
Applications accepted all year round

Funding Type

PhD Type

Nanoscience and technology, which involves the manipulation of materials using the property of size to bring about specific desired changes in the electronic structure of materials, has proven to be a powerful additional tool permitting the materials scientist to effect greater control over the charge transport properties in materials.
  Design, synthesis and evaluation of novel polysialyltransferase inhibitors as anti- metastatic agents
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Dr S Shnyder
Applications accepted all year round

Funding Type

PhD Type

Polysialic acid plays an essential role in neuronal development, but by adulthood is absent from the human body. Its biosynthesis is regulated by two polysialyltransferases (polySTs).
  Design, synthesis and evaluation of protease-activated anti-cancer prodrugs
  Research Group: Institute of Cancer Therapeutics
  Dr R Falconer, Prof P Loadman
Applications accepted all year round

Funding Type

PhD Type

Matrix metalloproteinases (MMPs) are a family of endoproteases that are overexpressed in tumours and play crucial roles in many tumourigenic processes, not least tumour invasion and angiogenesis.
  Determining brain glycosylation in ageing and Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr C Sutton
Applications accepted all year round

Funding Type

PhD Type

Increasing age is associated with lower levels of cognitive performance; concomitant with this is a decrease in brain glucose metabolism.
  Developing a tissue engineered/polyurethane blood vessel using bioengineering techniques
  Research Group: Chemistry and Biosciences
  Prof S Rimmer, Prof A M Graham, Dr K Riches-Suman
Applications accepted all year round

Funding Type

PhD Type

Vein graft failure is a significant issue in cardiovascular disease patients, with restenosis caused by alterations in flow patterns leading to remodelling and disease progression.
  Development of heterocyclic pharmacophores using diversity-oriented synthesis
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Prof L Patterson
Applications accepted all year round

Funding Type

PhD Type

Diversity-oriented synthesis (DOS) is a modern chemical tool, which aims to synthesise small molecules that cover new chemical space with the possibility of finding unexplored biological targets or pathways that may be important for disease progression.
  Development of highly stable porous composite membranes for separation of greenhouse gases
  Research Group: Chemistry and Biosciences
  Dr S Nayak, Prof S Rimmer
Applications accepted all year round

Funding Type

PhD Type

Metal-organic frameworks or MOFs are a class of porous materials made of metal ions and rigid organic linkers, which are known as secondary building units or SBUs.
  Development of stimuli-responsive metallosupramolecular architectures for sensing and/or delivery of medicine for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Dr S Pike
Applications accepted all year round

Funding Type

PhD Type

Colorectal cancer is among the most commonly diagnosed cancer and ranks as the third leading cause of cancer related mortality worldwide.
  Development of transdermal protein liposomal delivery system for the treatment of dermatological diseases
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Biopharmaceuticals have been increasingly used in the treatment of skin diseases. However, due to the poor absorption of peptide and protein through the skin, they are usually delivered through injections.
  Directed Co-Crystallisation of Pharmaceuticals: developing a predictive method for co-crystallisation
  Research Group: Chemistry and Biosciences
  Dr C Seaton
Applications accepted all year round

Funding Type

PhD Type

In this project, we propose to use a combination of computational and experimental techniques to develop a predictive method for co-crystallisation.
  Discovery and Development of Biocatalytic Solutions to Mitigate Microplastic Pollution
  Research Group: Chemistry and Biosciences
  Dr T Swift, Dr R Hamed, Dr U Sivarajah
Applications accepted all year round

Funding Type

PhD Type

Plastic contamination is a great ecological disaster facing modern society; a burden overwhelmingly heaped on the least economically developed countries.
  Discovery of chemical and biological tools to probe hypoxic solid tumours
  Research Group: Institute of Cancer Therapeutics
  Dr K Pors, Dr J Elies Gomez
Applications accepted all year round

Funding Type

PhD Type

A major challenge in cancer therapy is to develop therapeutic agents that selectively target tumour cells. One avenue towards the development of more selective cancer therapies is to exploit the unique physiological properties of solid tumours using prodrug approaches.
  Effect of nanoparticles on cellular conditions in lymphocytes and germ cells in vitro
  Research Group: Chemistry and Biosciences
  Prof D Anderson, Dr M Najafzadeh
Applications accepted all year round

Funding Type

PhD Type

The use of metals such as silver (Ag), gold (Au) and copper (Cu) as nanoparticles (NPs) and other chemicals such as Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) (Najafzadeh et al., 2016) in medical and lifestyle applications has exponentially increased in recent years, yet little is still known about their impact on DNA and RNA in somatic as well as in germ cells (Habas et al 2018).
  Electrophysiological changes in ion channels in human haploid and diploid (spermatozoa and lymphocytes) after nanoparticle exposure
  Research Group: Chemistry and Biosciences
  Dr L Shang, Dr M H Brinkworth, Prof D Anderson
Applications accepted all year round

Funding Type

PhD Type

Nanomaterial-mediated delivery represents a promising technique for repro- and geno- toxicology with a potential to improve the safety and efficacy of existing methodologies, including experimental gene therapy and sperm-mediated gene transfer.
  Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the role in acquired drug resistance in colon cancer
  Research Group: Institute of Cancer Therapeutics
  Dr S Shnyder, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Despite treatment advances, one of the most common cancers, colorectal cancer (CRC), still has a 45% mortality rate, and one of the major problems is the build-up of resistance to cancer drugs during treatment (‘acquired resistance’) such that over time the drugs stop working.
  ERK5 MAPK signalling in Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr J Muller, Dr S Kantamneni
Applications accepted all year round

Funding Type

PhD Type

Neurodegenerative diseases have devastating effects on individuals’ lives and our society, with no effective treatments available.
  Formulation and evaluation of umbilical cord-derived mesenchymal stem cells exosomes and antioxidants, incorporated in nanoliposomes using microfluidics, for the treatment of solid tumours
  Research Group: Chemistry and Biosciences
  Dr M Najafzadeh, Prof D Anderson, Dr M Isreb
Applications accepted all year round

Funding Type

PhD Type

This project uses the Cord blood Stem Cells from healthy control and the white blood cells of blood cancer patients to investigate the efficacy and genotoxicity of different compounds in them by using various genetic endpoints.
  Health Opportunity for Patient Empowerment in Gestational Diabetes (HOPE-GDM)
  Research Group: Chemistry and Biosciences
  Prof A M Graham, Prof R Qahwaji, Prof A Locke
Applications accepted all year round

Funding Type

PhD Type

Gestational Diabetes is a temporary condition diagnosed at 24-28 weeks gestation, where the body is unable to maintain normal blood glucose levels due to insulin resistance during pregnancy.
  Healthcare Degrees: What are the key drivers and influencers in choosing a healthcare career?
  Research Group: Education Innovation Research and Development
  Dr S Twedell
Applications accepted all year round

Funding Type

PhD Type

This project will investigate the current factors that influence applicants’ decisions to study for a healthcare degree and pursue a vocational career.
  Identification of colistin resistant gene, mcr-1, in clinical isolated Enterobacteriaceae and characterisation of pathogenicity and virulence of mcr-1 harboured bacterial pathogens
  Research Group: Chemistry and Biosciences
  Dr C Chang, Dr J N Fletcher
Applications accepted all year round

Funding Type

PhD Type

Globally, infectious disease accounts for more than 13 million deaths a year and is one of the main causes of death around the world, predominantly in developing countries.
  Identifying glucose-dependent mechanisms underlying risk factors for Alzheimer’s disease
  Research Group: Pharmacology and Experimental Therapeutics
  Dr R Williamson, Dr S McLean
Applications accepted all year round

Funding Type

PhD Type

Several risk factors for Alzheimer’s disease including diabetes and midlife obesity are age-dependent and have an obvious metabolic component resulting in impaired glucose metabolism.
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