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University of Leeds, Faculty of Medicine and Health PhD Projects, Programs & Scholarships

We have 25 University of Leeds, Faculty of Medicine and Health PhD Projects, Programs & Scholarships

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  (MCRC Clinical - Leeds-Manchester) Improving the response to neoadjuvant chemotherapy in advanced colon cancer: the relationship between tumour immunology and the microbiome
  Dr N West, Prof Mark Saunders, Prof P Quirke
Application Deadline: 1 December 2019

Funding Type

PhD Type

Colon cancer is a common cause of cancer-related mortality and outcomes are not improving at the same rate as for rectal cancer. High risk patients currently undergo surgery followed by adjuvant chemotherapy.
  (MCRC Clinical - Leeds-Manchester) Multi-parametric MRI as a biomarker in CNS radiotherapy trials
  Prof S Short, Dr Stuart Currie, Dr L Murray, Dr M Merchant
Application Deadline: 1 December 2019

Funding Type

PhD Type

This project will apply advanced MR imaging techniques to the problem of risk estimation in patients undergoing complex CNS radiotherapy interventions.
  (MCRC Clinical - Leeds-Manchester) Personalising re-irradiation of locally recurrent prostate cancer directed by MR imaging and hypoxia biomarkers
  Dr Ann Henry, Dr Sarah Brown, Prof D Buckley, Prof A Choudhury
Application Deadline: 1 December 2019

Funding Type

PhD Type

External beam radiotherapy (EBRT) is the most commonly used primary treatment for men with non-metastatic prostate cancer. Outcomes are generally good but 20-50% of patients will develop recurrent disease within 10 years.
  Characterisation of a pre-osteoblast subset of human mesenchymal stem cells: implications for novel osteoarthritis and osteoporosis treatment development
  Dr E Jones, Prof D McGonagle
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) and osteoporosis (OP) are the most common age-related skeletal diseases. They seriously affect patient’s quality of life and represent a significant healthcare burden to the UK society.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Development of a Core Outcome Set relevant to assess effectiveness of longer-term stroke care.
  Prof A Forster
Application Deadline: 26 November 2019

Funding Type

PhD Type

In stroke, our research is focused on enhancing rehabilitation and improving the longer-term outcomes for stroke survivors and their carers.
  Digital health technology and patient safety
  Dr J Benn, Dr O Johnson
Application Deadline: 29 November 2019

Funding Type

PhD Type

This is an exciting opportunity to undertake a PhD within the Yorkshire and Humber Patient Safety Translational Research Centre (Yorkshire and Humber PSTRC), a partnership between the University of Leeds and Bradford Teaching Hospitals Foundation funded by the National Institute for Health Research (NIHR).
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Exploration of models/systems of longer-term care for stroke survivors with aphasia.
  Prof A Forster
Application Deadline: 26 November 2019

Funding Type

PhD Type

In stroke, our research is focused on enhancing rehabilitation and improving the longer-term outcomes for stroke survivors and their carers.
  Exploring the mitotic functions of ASPM in human brain size regulation
  Dr J Bond, Dr E E Morrison, Prof M Peckham
Applications accepted all year round

Funding Type

PhD Type

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation.
  Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
  Prof L Houghton
Applications accepted all year round

Funding Type

PhD Type

Gastroesophageal reflux (GER) is associated with many lung diseases, including but not limited to idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), non-CF bronchiectasis, asthma and idiopathic chronic cough.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
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