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University of Leeds, Faculty of Medicine and Health PhD Projects, Programs & Scholarships

We have 25 University of Leeds, Faculty of Medicine and Health PhD Projects, Programs & Scholarships

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  (MCRC Clinical - Leeds-Manchester) Improving the response to neoadjuvant chemotherapy in advanced colon cancer: the relationship between tumour immunology and the microbiome
  Dr N West, Prof Mark Saunders, Prof P Quirke
Application Deadline: 1 December 2019

Funding Type

PhD Type

Colon cancer is a common cause of cancer-related mortality and outcomes are not improving at the same rate as for rectal cancer. High risk patients currently undergo surgery followed by adjuvant chemotherapy.
  (MCRC Clinical - Leeds-Manchester) Multi-parametric MRI as a biomarker in CNS radiotherapy trials
  Prof S Short, Dr Stuart Currie, Dr L Murray, Dr M Merchant
Application Deadline: 1 December 2019

Funding Type

PhD Type

This project will apply advanced MR imaging techniques to the problem of risk estimation in patients undergoing complex CNS radiotherapy interventions.
  (MCRC Clinical - Leeds-Manchester) Personalising re-irradiation of locally recurrent prostate cancer directed by MR imaging and hypoxia biomarkers
  Dr Ann Henry, Dr Sarah Brown, Prof D Buckley, Prof A Choudhury
Application Deadline: 1 December 2019

Funding Type

PhD Type

External beam radiotherapy (EBRT) is the most commonly used primary treatment for men with non-metastatic prostate cancer. Outcomes are generally good but 20-50% of patients will develop recurrent disease within 10 years.
  Characterisation of a pre-osteoblast subset of human mesenchymal stem cells: implications for novel osteoarthritis and osteoporosis treatment development
  Dr E Jones, Prof D McGonagle
Applications accepted all year round

Funding Type

PhD Type

Osteoarthritis (OA) and osteoporosis (OP) are the most common age-related skeletal diseases. They seriously affect patient’s quality of life and represent a significant healthcare burden to the UK society.
  Developing pluripotent stem cell models of inherited retinal diseases
  Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Background. Inherited retinal dystrophies are a leading cause of blindness and visual loss in the UK working age population. However, despite the widespread diagnostic use of next-generation sequencing, a molecular genetic diagnosis is unavailable for many patients world-wide.
  Development of a Core Outcome Set relevant to assess effectiveness of longer-term stroke care.
  Prof A Forster
Application Deadline: 26 November 2019

Funding Type

PhD Type

In stroke, our research is focused on enhancing rehabilitation and improving the longer-term outcomes for stroke survivors and their carers.
  Digital health technology and patient safety
  Dr J Benn, Dr O Johnson
Application Deadline: 29 November 2019

Funding Type

PhD Type

This is an exciting opportunity to undertake a PhD within the Yorkshire and Humber Patient Safety Translational Research Centre (Yorkshire and Humber PSTRC), a partnership between the University of Leeds and Bradford Teaching Hospitals Foundation funded by the National Institute for Health Research (NIHR).
  Enhancing Oncolytic Virus-induced Immunotherapy using Eicosapentaenoic Acid (EPA)
  Dr F Errington-Mais, Dr MA Volpato
Applications accepted all year round

Funding Type

PhD Type

Breast cancer is the most commonly diagnosed cancer in women with triple-negative breast cancer (TNBC) having the worst prognosis, highest death rate and lowest overall survival.
  Epigenetic therapy using ultrasound-mediated microbubble drug delivery for cancer treatment
  Dr E Valleley, Dr L Coletta
Applications accepted all year round

Funding Type

PhD Type

The project is an interdisciplinary, pre-clinical study that aims to investigate the response of human tumour cells to treatment with epigenetic inhibitors (such as DNA methyltransferase inhibitors), as a potential combination therapy for colorectal cancer (CRC).
  Exploration of models/systems of longer-term care for stroke survivors with aphasia.
  Prof A Forster
Application Deadline: 26 November 2019

Funding Type

PhD Type

In stroke, our research is focused on enhancing rehabilitation and improving the longer-term outcomes for stroke survivors and their carers.
  Exploring the mitotic functions of ASPM in human brain size regulation
  Dr J Bond, Dr E E Morrison, Prof M Peckham
Applications accepted all year round

Funding Type

PhD Type

The increase in relative brain size is one of the most striking events in human evolution. To determine how human brain size is normally regulated we have investigated the cause of autosomal recessive primary microcephaly (MCPH), a congenital disorder of reduced brain size and associated mental retardation.
  Gastroesophageal reflux in respiratory disease: pathogenic role and improved management
  Prof L Houghton
Applications accepted all year round

Funding Type

PhD Type

Gastroesophageal reflux (GER) is associated with many lung diseases, including but not limited to idiopathic pulmonary fibrosis (IPF), non-IPF interstitial lung disease (ILD), chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), non-CF bronchiectasis, asthma and idiopathic chronic cough.
  Genetic studies of corneal endothelial dystrophies and development of alternative treatment options
  Dr M Ali
Applications accepted all year round

Funding Type

PhD Type

The cornea is the protective front part of the eye that provides most of the eyes focusing power. The endothelium is a single-cell layer on the inside of the cornea that maintains fluid balance and is required for corneal transparency.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Metabolic reprogramming in cancer: starving tumors of essential nutrients to promote cell death
  Dr S Papa
Applications accepted all year round

Funding Type

PhD Type

All the cells in our bodies are programmed to die. As they get older, our cells accumulate toxic molecules that make them sick. In response, they eventually break down and die, clearing the way for new, healthy cells to grow.
  Molecular approaches to modulate antibody receptor signalling in autoimmunity
  Dr J Robinson, Prof A Morgan
Application Deadline: 13 January 2020

Funding Type

PhD Type

Autoantibody-mediated inflammatory diseases are characterised by a proinflammatory feedback loop which leads to the destruction of tissues, prolonged pain, fatigue and subsequent reduction in life quality.
  Novel regulators of +TIP localisation and function
  Dr E E Morrison, Dr S Bell, Dr J Bond
Applications accepted all year round

Funding Type

PhD Type

Microtubules (MTs) are a key cytoskeletal network in all eukaryotic cells. MTs grow and shrink primarily through the addition or loss of tubulin heterodimers from their plus end.
  Raithby Studentship: PhD in Health Data Science
  Dr C Smith
Application Deadline: 6 December 2019

Funding Type

PhD Type

This scholarship provides an opportunity to learn about and apply modern approaches to the analysis of health data – with a focus on exploring the interaction between physical and mental health.
  Raithby Studentship: PhD in Health Data Science
  Dr C Smith
Application Deadline: 6 December 2019

Funding Type

PhD Type

This scholarship provides an opportunity to develop and apply novel methods for the analysis of health data to explore the interaction between physical and mental health.
  The functional characterization of the tumour suppressor gene CSMD1 in breast cancer
  Dr S Bell
Applications accepted all year round

Funding Type

PhD Type

CUB and Sushi multiple domains protein 1 (CSMD1) maps to 8p23, a region deleted in many cancers including breast cancer. Our previous work has established that CSMD1 is an independent prognostic marker in ductal breast cancer, with reduced expression associated with high tumour grade and poor survival1.
  Understanding the long-term implications of treatment of rare brain tumours on health-related quality of life: a European cross-sectional study
  Dr F Boele, Prof G Velikova
Application Deadline: 29 November 2019

Funding Type

PhD Type

The prognosis of brain tumours varies greatly per subgroup and can depend on the molecular profile of the tumour.
  Using massively-paralleled sequencing to find the cause of inherited conditions that affect the front of the eye
  Dr M Ali, Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Eye diseases are a common cause of human disability and many of them are inherited. These include congenital as well as adult-onset conditions and diseases of ageing, and may involve abnormalities at the back of the eye or the anterior eye structures.
  Using next-generation sequencing and CRISPR-Cas9 gene editing to investigate penetrance and phenotypic variation in inherited eye disease
  Dr C Toomes
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal diseases (IRDs) result from mutations in over 250 different genes, many of them implicated by the Leeds Vision Research Group (eg Panagiotou et al 2017, AJHG 100:960-968; El-Asrag et al 2015, 96:948-54).
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