We have 47 University of Leeds, Faculty of Medicine and Health PhD Projects, Programmes & Scholarships for Self-funded Students

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University of Leeds, Faculty of Medicine and Health PhD Projects, Programmes & Scholarships for Self-funded Students

We have 47 University of Leeds, Faculty of Medicine and Health PhD Projects, Programmes & Scholarships for Self-funded Students

NIHR Leeds BRC: Utilising genetic and genomic predictors of vasculitis and disease/treatment complications for application in routine clinical practice

University of Leeds Faculty of Medicine and Health

There is substantial interest in using genetic biomarkers to predict those most at risk of disease and treatment complications; this is one of the focuses of Our Future Health, a national study aiming to recruit 5M participants ( https://ourfuturehealth.org.uk/ ). Read more

Supervisors: Prof A Morgan, Dr MM Iles, Dr R Mujica-Mota

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Using health data to flip the inverse care law in polymyalgia rheumatica

University of Leeds Faculty of Medicine and Health

Polymyalgia rheumatica (PMR) is a common inflammatory musculoskeletal disease affecting older people. It is treated in primary care with long-term corticosteroids (prednisolone). Read more

Supervisors: Dr S Mackie, Prof A Clegg, Dr K Best

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Using early simulation modelling to estimate the health care system impact of new technologies and inform technology development

University of Leeds Faculty of Medicine and Health

Evidencing the value of new technologies is an important step in securing market access and allowing patients to benefit from innovations. Read more

Supervisors: Dr A Vargas-Palacios, Dr D Meads, Prof H Pandit

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Unravelling the pre-clinical immunology of the IL-23/1L-17 axis in axial inflammation in psoriatic arthritis towards optimal disease prevention

University of Leeds Faculty of Medicine and Health

Psoriatic arthritis (PsA) and ankylosing spondylitis (AS) are key disorders within the seronegative spondylarthropathy (SpA) that was first described in… Read more

Supervisors: Prof D McGonagle, Dr H Marzo-Ortego, Dr T Macleod

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: The role of target organs in initiation of autoimmunity in systemic lupus erythematosus

University of Leeds Faculty of Medicine and Health

Autoimmune diseases such as SLE have traditionally been understood to result from aberrant haematopoietic adaptive immune system that targets normal tissues such as the skin and joints. Read more

Supervisor: Dr E Vital

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: The microbiome and the promotion of bowel cancer: The key to understanding causation and prevention of this important disease

University of Leeds Faculty of Medicine and Health

Bowel cancer is the second commonest cause of cancer death in the UK and affects 1.9 million people annually worldwide. Its cause is still unknown but recent work by Wood et al. Read more

Supervisors: Dr K Marks, Dr H Wood, Dr N West, Prof P Quirke

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Targeting systemic inflammation to treat joint pain

University of Leeds Faculty of Medicine and Health

Osteoarthritis (OA) is the commonest arthritis and affects >530 million people globally; prevalent cases increased 113% since 1990. Read more

Supervisors: Prof P Conaghan, Dr S Kingsbury

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Pre-clinical evaluation of novel regenerative medicine strategies for knee osteoarthritis

University of Leeds Faculty of Medicine and Health

Historically, articular cartilage was considered incapable of spontaneous repair. However, biomechanical correction in osteoarthritis (OA) using high tibial osteotomy or joint distraction demonstrated the remarkable joint to regeneration by “merely” correcting joint alignment. Read more

Supervisors: Prof H Pandit, Prof D McGonagle

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Network meta-analysis methods for assessment of complex interventions in the early phase setting

University of Leeds Faculty of Medicine and Health

Rehabilitation aims to enhance and restore functioning and quality of life and treatment interventions can be multiple and varied, for example, medication, physiotherapy, nutrition, life style interventions, devices. Read more

Supervisors: Prof D Stocken, Mr N Corrigan, Dr R Walwyn

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Multimodal predictive modelling of outcome in patients with gastrointestinal cancer

University of Leeds Faculty of Medicine and Health

Worldwide, cancer of the upper (oesophagus, stomach) and lower gastrointestinal (colon and rectum) tract is newly diagnosed in 3.6 million patients every year and 2.2 million patients die from this disease every year. Read more

Supervisors: Dr H Grabsch, Dr N West, Dr D Magee

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Methods to improve research recruitment prediction in complex trials: improved learning from pilot or early phase work

University of Leeds Faculty of Medicine and Health

Recruitment to research studies can be challenging and it is recognised that site level barriers can be unique, widespread and varied with no universal solution. Read more

Supervisors: Prof D Stocken, Mr N Corrigan, Miss J Croft

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Incorporating patient and health care preferences early in the innovation pathway to inform technology development

University of Leeds Faculty of Medicine and Health

The resources and time required to move from early biomedical research to clinical trials can be substantial. Read more

Supervisors: Dr D Meads, Dr P Cocco

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Improving understanding of the use and interpretation of risk prediction tools

University of Leeds Faculty of Medicine and Health

There are many risk prediction tools developed but only a fraction make it to routine clinical use. The reasons are multiple, for example some are geographically specific, many remain unvalidated, some lack clinical utility. . Read more

Supervisors: Dr N Rousseau, Prof D Stocken, Prof DC Cairns

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Improving hip replacement surgery for at risk patient cohort

University of Leeds Faculty of Medicine and Health

More than 10% of the UK population aged over 45 have hip osteoarthritis and there are nearly 100,000 total hip replacement (THR) surgeries performed every year. Read more

Supervisors: Dr R K Wilcox, Dr S Williams, Dr A Jones, Prof A Redmond

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Force sensing mechanisms of haemostasis in heart failure and diabetes

University of Leeds Faculty of Medicine and Health

Since the original identification of the role of PIEZO1 in vascular integrity and endothelial cell biology by our group in Leeds in 2014, there have been many publications on the role of PIEZO1 in endothelial function and its role in processes such as atherosclerosis, hypertension, cell-cell junctions, vascular permeability and leukocyte diapedesis. Read more

Supervisors: Dr R Ariens, Prof D J Beech, Dr E Levelt

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Exploring the impact of 'hidden' antibiotic resistance

University of Leeds Faculty of Medicine and Health

Antibiotics make possible the treatment of life-threatening infections and have added over a decade to average human lifespan. Read more

Supervisors: Prof A O'Neill, Dr K Davies, Dr J Sandoe

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: Development and application of fast Magnetic Resonance Spectroscopic Imaging methods for metabolic profiling

University of Leeds Faculty of Medicine and Health

Altered metabolism is a hallmark of many disease states, including cardiovascular and musculoskeletal conditions. Importantly, metabolic profiles may be patient-specific and may for example indicate susceptibility to treatment or malignancy. Read more

Supervisors: Prof S Plein, Prof J Schneider

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

NIHR Leeds BRC: An interferon diagnostic to inform early detection and prevention strategies in Ana positive CTDs

University of Leeds Faculty of Medicine and Health

Type I interferons (IFN) play a role in a wide range of rheumatic and musculoskeletal diseases (RMDs), and strong evidence suggests that measurement of IFN activity could have clinical value, although testing has not progressed into clinical settings. Read more

Supervisors: Dr F Del Galdo, Dr R Ross

26 May 2024 PhD Research Project Competition Funded PhD Project (UK Students Only)

Last chance to apply

Childhood trauma, stress and suicide risk: Advancing understanding of mechanisms of action

University of Leeds Faculty of Medicine and Health

This fully funded PhD place provides an exciting opportunity to pursue postgraduate research into the pathways that link childhood trauma, stress and suicide risk. Read more

Supervisors: Prof D O'Connor, Dr AJ Prestwich

23 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

Last chance to apply

Working memory and cognitive offloading in children and adults

University of Leeds Faculty of Medicine and Health

One full scholarship is available in the School of Psychology in 2024/25. This scholarship is open to UK applicants and covers UK tuition fees for three years plus an annual maintenance stipend equivalent to a UKRI funded scholarship, and a £3000 Research Support Training Grant (over the course of the PhD). . Read more

Supervisors: Dr R Allen, Dr L Superbia Guimaraes, Prof A Waterman

23 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

Last chance to apply

Dimensions of motivation to eat, appetite control and obesity management

University of Leeds Faculty of Medicine and Health

This fully funded PhD place provides an exciting opportunity to pursue postgraduate research in appetite, energy balance and obesity research. . Read more

Supervisors: Prof J Stubbs, Dr M Hopkins, Prof G Finlayson, Dr K Beaulieu

23 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

Last chance to apply

Towards understanding the role of chronotype, sleep and timing of physical activity and food intake in appetite control and energy balance

University of Leeds Faculty of Medicine and Health

This fully funded PhD place provides an exciting opportunity to pursue postgraduate research in a range of fields relating to appetite control, energy balance, sleep and chronobiology with experts from the University of Leeds and the University of Chicago. Read more

Supervisors: Dr K Beaulieu, Dr M Hopkins, Prof G Finlayson

23 April 2024 PhD Research Project Funded PhD Project (UK Students Only)

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

University of Leeds Faculty of Medicine and Health

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.

University of Leeds Faculty of Medicine and Health

Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more

Supervisors: Prof D Peckham, Prof D Jayne, Dr S Savic, Miss LR Caley

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

University of Leeds Faculty of Medicine and Health

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Supervisors: Dr G Mavria, Dr S Bell

Year round applications PhD Research Project Self-Funded PhD Students Only

Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

University of Leeds Faculty of Medicine and Health

Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more

Supervisor: Dr P Laslo

Year round applications PhD Research Project Self-Funded PhD Students Only

Oncology: Evaluating Photodynamic Therapy in colorectal cancer using patient-derived organoids

University of Leeds Faculty of Medicine and Health

Colorectal cancer (CRC) is the 3rd most common cancer worldwide. Surgery is first line treatment and often in adjunct with chemotherapy. Read more

Supervisors: Dr I Knot, Prof D Jayne

Year round applications PhD Research Project Self-Funded PhD Students Only

Translational Medicine: Understanding the mechanism(s) of resistance to EPA to personalise therapy and improve outcome

University of Leeds Faculty of Medicine and Health

Advanced colorectal cancer (CRC) is the UK’s second most lethal cancer, with limited treatment options for unresectable metastatic tumours. Read more

Supervisors: Dr MA Volpato, Prof M Hull

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer Biology: The role of Wnt signaling in glioblastoma therapeutic resistance

University of Leeds Faculty of Medicine and Health

Glioblastoma is a deadly brain tumour treated with surgery, radiotherapy and chemotherapy with patient survival of 6-15 months. Read more

Supervisors: Dr G Mavria, Dr S Bell, Dr C Toomes

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer: Understanding the immunosuppressive role of fibroblast and macrophages in Breast cancer

University of Leeds Faculty of Medicine and Health

Oncolytic viruses (OVs) preferentially infect and kill cancer cells, and their clinical efficacy has been demonstrated against a number of different cancers. The most clinically advanced OV is a genetically engineered herpes simplex virus (T-VEC) which expresses GMCSF to aid the development of anti-tumour immune responses; T-VEC is approved for the treatment of metastatic melanoma. Read more

Supervisors: Dr F Errington-Mais, Dr V Jennings

Year round applications PhD Research Project Self-Funded PhD Students Only

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