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Genetics (cardiomyopathy) PhD Projects, Programs & Scholarships

We have 5 Genetics (cardiomyopathy) PhD Projects, Programs & Scholarships

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We have 5 Genetics (cardiomyopathy) PhD Projects, Programs & Scholarships

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Elucidating the role of disease modifying gene variants in inherited cardiomyopathies using induced pluripotent stem cell derived cardiomyocytes and CRISPR/Cas-9.

Our group is interested in uncovering and understanding key mechanisms of disease that affect cardiac muscle function. We have a particular interest in understanding how regulation of cardiac muscle contraction is altered in common acquired and inherited cardiovascular diseases. Read more

Understanding the role of alpha-actinin in cardiac disease: from molecules to in vivo models

In the heart and skeletal muscle, the Z-disc is a crucial structure to anchor thin filaments of the contractile units. Moreover, the Z-disc is recognised as a signalling hub, sensing and responding to changes in the environment. Read more

Cellular protein quality control in diabetes-associated heart disease: The insight into mechanisms and therapeutic potentials

Cardiovascular complications are the leading causes of diabetes mortality. With the exception of vascular and valvular injuries, diabetic cardiomyopathy (DCM) is a distinct myocardial disease, which is characterised by abnormal cellular metabolism and defects in organelles function, leading to impaired cardiac function. Read more
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