Genetics (english language) PhD Projects, Programmes & Scholarships

University of Dundee School of Medicine

Leveraging novel automated diagnostic pathways with augmented precision medicine approaches for the early detection and risk stratification of liver disease

Liver disease represents one of the fastest-growing causes of morbidity and mortality in the world. The principle aetiological variants are contained within the new nomenclature of steatotic liver disease (SLD). Read more

Supervisors: Dr P Brennan, Prof J F Dillon, Dr M Al-Khairalla

30 June 2024 PhD Research Project Self-Funded PhD Students Only

University of Dundee School of Medicine

Utility of in silico prediction tools to aid variant interpretation

Accurate variant interpretation represents is essential for the successful implementation of genetic testing in the clinical setting. Read more

Supervisor: Dr P Newey

30 June 2024 PhD Research Project Self-Funded PhD Students Only

University of Dundee School of Medicine

Using chemical-genetics to inhibit and characterise “undruggable” enzymes

The ability to inhibit kinases with small molecule drugs has transformed our understanding of signalling networks. It has allowed us to define the substrates and processes that each kinase controls, and to map how these enzymes cooperate within signalling pathways. Read more

Supervisors: Dr A Saurin, Dr T Ly

30 June 2024 PhD Research Project Self-Funded PhD Students Only

University of Dundee School of Life Sciences

Expanding the ligandable E3 ubiquitin ligases for targeted protein degradation

Out of more than 600 E3 ubiquitin ligases in cells, currently only a handful have small molecule binders that can be used for PROteolysis Targeting Chimeras (PROTACs) and harnessed for targeted protein degradation. Read more

Supervisors: Prof G Sapkota, Dr S Virdee

30 June 2024 PhD Research Project Self-Funded PhD Students Only

Disrupted SUMO signalling in epithelial cancers, implications for genome stability and response to therapy.

Year round applications PhD Research Project Self-Funded PhD Students Only

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisor: Dr A Garvin

Investigation of host-virus interactions

Supervisors: Dr M Stacey, Dr J N Barr

The School of Molecular and Cellular Biology invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25 in the area of molecular virology. Read more

Year round applications PhD Research Project Self-Funded PhD Students Only

Employing molecular virology to investigate hepatitis E virus replication

Supervisors: Dr M.R. Herod, Prof M Harris

This project is available to self funded candidates only. The Herod lab has a broad interest in virus replication, with a particular interest in studying single-stranded positive-sense RNA viruses important for human and animal health. Read more

Year round applications PhD Research Project Self-Funded PhD Students Only

Targeting protein acetylation to reduce microglia activation in neurodegenerative disorders

Year round applications PhD Research Project Self-Funded PhD Students Only

The School of Biomedical Sciences invites applications from prospective postgraduate researchers who wish to commence study for a PhD in the academic year 2024/25. Read more

Supervisor: Prof I Wood

Newcastle University Translational and Clinical Research Institute

PhD studentship - Commercial Applications of Skin Bioenergy Research

Value of award . 100% of Home tuition fees paid and UKRI stipend for annual living expenses. A successful international candidate needs to fund the difference between the UK and international fees. . Read more

Supervisor: Prof M Birch-Machin

30 April 2024 PhD Research Project Funded PhD Project (Students Worldwide)

Epigenetics and Cancer: Determining how Mistakes in V(D)J Recombination Trigger Leukaemias and Lymphomas

Year round applications PhD Research Project Self-Funded PhD Students Only

V(D)J recombination is essential to produce an effective adaptive immune system but since the reaction involves breakage and rejoining of DNA, it is highly dangerous and errors have long been thought to lead to leukaemias and lymphomas. Read more

Supervisor: Dr J Boyes

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Supervisors: Prof P Hopkins, Dr M-A Shaw, Dr C Diggle

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer: Investigation of accentuated mitochondrial ROS and NLRP3 inflammasome activation in cystic fibrosis and colorectal carcinoma.

Supervisors: Prof D Peckham, Prof D Jayne, Dr S Savic, Miss LR Caley

Cystic fibrosis (CF) is associated with an accentuated inflammatory response to bacterial lipopolysaccharides (LPS), increased resting energy expenditure and a higher than expected prevalence of gastrointestinal and other malignancies. Read more

Year round applications PhD Research Project Self-Funded PhD Students Only

Cancer: Characterization of EGFR signaling activated by the endothelium in the process of breast cancer metastasis to the brain

Supervisors: Dr G Mavria, Dr S Bell

The Epidermal Growth Factor Receptor (EGFR) is important in normal physiology regulating epithelial development and homeostasis. In cancer, deregulation resulting from mutation, amplification or transcriptional upregulation promotes tumorigenesis. Read more

Year round applications PhD Research Project Self-Funded PhD Students Only

Haematology: Oncogenic reprogramming of immune cells; novel mechanism for drug resistance in leukaemia

Year round applications PhD Research Project Self-Funded PhD Students Only

Under pathogenic challenges, cells of the haematopoietic system become epigenetically reprogrammed and establish immune memory. Read more

Supervisor: Dr P Laslo