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Genetics (recombinant) PhD Projects, Programs & Scholarships

We have 12 Genetics (recombinant) PhD Projects, Programs & Scholarships

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  Cross presentation of antigens of recombinant overlapping peptides to optimise vaccines against tumour and infectious diseases
  Dr S Jiang, Dr N Burgess-Brown
Application Deadline: 4 December 2019

Funding Type

PhD Type

THE PROJECT. We have developed a technology to producing overlapping peptides - bacterial expression of an amino acid sequence corresponding to overlapping peptide sequences spanning the length of a protein of interest interspersed with enzymatic cleavage sites.
  Developing a virus-like particle (VLP) Polio vaccine
  Dr G Mulley
Applications accepted all year round

Funding Type

PhD Type

Rationale. Poliovirus is a non-enveloped RNA virus, spread via the faecal-oral route, that causes the infectious disease Poliomyelitis (Polio).
  Stress regulation of protein translation: role in cancer and neurodegeneration
  Dr A J Whitmarsh, Prof M Ashe
Applications accepted all year round

Funding Type

PhD Type

Cells are subjected to a range of stresses that include physical injury, changes in oxygen levels or temperature, nutrient deprivation, radiation and infection.
  Multimerisation of ELAV/Hu proteins – a key mechanism ensuring specificity for RNA recognition in health and disease
  Dr M Soller, Dr T Knowles
Applications accepted all year round

Funding Type

PhD Type

Aims. Determine the structure of the ELAV dodecameric complex bound to target RNA by cryoEM and functionally probe interaction interfaces in vitro and in vivo in transgenic Drosophila models for neurodegeneration and cancer.
  MRC DTP 4 Year PhD Programme: Structural and developmental mechanics in polarized membrane trafficking
  Dr D H Murray, Dr J Januschke
Application Deadline: 11 January 2020

Funding Type

PhD Type

This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
  EASTBIO Genome editing for resistance to white spot syndrome virus in whiteleg shrimp
  Dr R Houston, Dr C Burkard
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute. Shrimp is one of the most important aquaculture groups worldwide, representing 16 % of the world trade of aquatic products in value (FAO 2018, http://www.fao.org/3/I9540EN/i9540en.pdf).
  An extended histone code at bivalent domains and its role in poising developmental genes in embryonic stem cells
  Research Group: Institute of Cell Biology
  Dr P Voigt
Application Deadline: 5 January 2020

Funding Type

PhD Type

Histone modifications play key roles in the regulation of gene expression. In embryonic stem cells, promoters of developmental genes simultaneously carry histone H3 lysine 4 trimethylation (H3K4me3), which is usually found at active promoters, and H3K27me3, a hallmark of repressive chromatin.
  Understanding drug-resistance in myeloid cancer
  Dr P Laslo
Applications accepted all year round

Funding Type

PhD Type

Under pathogenic challenges, cells of the innate system become epigenetically reprogrammed and establish immune memory.
  Role of BTG1 and BTG2 in acute lymphocytic leukaemia and diffuse large B-cell lymphoma
  Dr G S Winkler
Applications accepted all year round

Funding Type

PhD Type

Acute lymphocytic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) is often associated with small deletions of or point mutations in the highly related BTG1 or BTG2 genes.
  Silver ion-based antimicrobials: mechanisms of toxicity and resistance
  Dr G Mulley, Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The emergence and persistence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of silver ions.
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