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Genetics (selection) PhD Projects, Programs & Scholarships

We have 27 Genetics (selection) PhD Projects, Programs & Scholarships

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  Multilevel selection on transposition rates in cancer
  Dr L J Johnson
Applications accepted all year round

Funding Type

PhD Type

Cancer is an evolutionary process. Cells in a tumour vary due to mutation, and so over many generations they adapt in response to both intrinsic selective pressures (such as anoxia) and extrinsic selective pressures (such as chemotherapy).
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  De Novo Mutations and Human Disease
  Prof A Goriely, Prof A Wilkie
Application Deadline: 24 July 2020

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
  Immunogenetic Status of Salmonid Populations in Scotland
  Prof S Piertney, Dr M Wenzel, Dr D Morris, Dr J Gilbey
Application Deadline: 1 May 2020

Funding Type

PhD Type

The genetic integrity of wild salmon in Scotland is being challenged by interaction with escaped farmed fish.
  The genetics/genomics of adaptive evolutionary change
  Dr N Nadeau
Applications accepted all year round

Funding Type

PhD Type

The basic process of evolution by natural selection involves genetic changes that confer an advantage in survival or reproduction.
  Conservation Genomics and Epigenomics of Fragmented and Declining Populations
  Prof L Beheregaray
Applications accepted all year round

Funding Type

PhD Type

We are looking for a bright candidate for one PhD position associated with the project. “The evolutionary potential of fragmented and declining populations”.
  Investigate a novel, unexplored link between WNT signalling and regulators of cell migration in cancer progression using CRISPR-Cas9 and advanced live cell imaging.
  Dr M Krause
Applications accepted all year round

Funding Type

PhD Type

Cancer is a devastating disease. more than one in three people in the UK will develop cancer in their lifetime. WNT signalling is a key pathway controlling morphogenesis in embryos and it has been shown that perturbations of this pathway promote cancer progression.
  Four Year PhDs in Cancer, Immunology and Biomedicine

Funding Type

PhD Type

The Faculty of Medicine at the University of Southampton has a strong reputation in research, enterprise and education, with an emphasis on translating new discoveries from basic science into clinical innovation.
  Investigation of the processes that generate, maintain, and threaten biological diversity
  Dr R Riesch
Applications accepted all year round

Funding Type

PhD Type

Research in my group addresses one of the fundamental questions in evolutionary ecology.
  Epigenetic mechanisms of phenotypic plasticity and the evolution of adaptive responses
  Dr R Hager, Prof J McInerney
Applications accepted all year round

Funding Type

PhD Type

We now live in a world of rapidly changing environmental conditions where species will need to adapt or perish. While populations may evolve in response to environmental change, more rapid responses may happen through processes like phenotypic plasticity.
  MSc Project: Chronic lung infection – Investigation of the mechanisms of adaptation during chronic colonisation.
  Dr S McClean
Application Deadline: 3 April 2020

Funding Type

PhD Type

Chronic lung infections are associated with poor quality of life and mortality for people with underlying respiratory conditions such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD).
  Molecular characterization of Cryptosporidium parvum anthroponosum – A new threat to world health (TYLERMEDOct2020)
  Dr K Tyler, Prof N Hall
Application Deadline: 17 April 2020

Funding Type

PhD Type

Human cryptosporidiosis is the leading protozoan cause of diarrhoeal mortality worldwide, and most infection is caused by either person to person transmitted Cryptosporidium hominis or the presumptively zoonotic C.
  Precision Medicine DTP – Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach
  Research Group: Edinburgh Cancer Research Centre
  Prof V Brunton, Dr L Boulter, Dr M Taylor, Prof D M Salter
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Sarcomas are relatively uncommon cancers thought to arise from pluripotent mesenchymal stem cells. Undifferentiated pleomorphic soft tissue sarcoma (UPS), though one of the commonest sarcoma subtypes encountered, exemplify the limitations of historical progress in sarcoma therapy.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - Illuminating roles of Wnt/b-Catenin signalling in nonalcoholic fatty liver disease (NAFLD)
  Research Group: MRC Centre for Regenerative Medicine
  Dr K Kaji, Dr S Tomlinson, Prof J Fallowfield
Application Deadline: 6 April 2020

Funding Type

PhD Type

Background. Non-Alcoholic Fatty Liver Disease (NAFLD) caused by a high fat diet (HFD) is a growing major public health problem world-wide.
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