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Genetics (genes) PhD Projects, Programs & Scholarships

We have 100 Genetics (genes) PhD Projects, Programs & Scholarships

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  Genomics, gene regulation and disease: how mammalian genes are regulated and how their deregulation is linked with human disease
  Assoc Prof J Hughes, Prof T Milne
Application Deadline: 26 July 2019

Funding Type

PhD Type

The Hughes group is interested in how mammalian genes are regulated and how their deregulation is linked with human disease. The ~22 thousand genes in the mammalian genome are present in the DNA of every cell but are used in complex patterns in different cell types and organs.
  Identification and functional characterisation of BRIT1/MCPH1 synthetic lethal genes to treat breast and ovarian cancer
  Dr S Bell, Prof C A Johnson
Applications accepted all year round

Funding Type

PhD Type

Women who have undergone surgery for breast and ovarian cancer often have additional chemotherapy to kill residual cancer cells and prevent recurrence.
  Investigation of the role of myopia susceptibility genes in early eye development.
  Prof L Erskine, Prof N Vargesson, Prof M Collinson
Application Deadline: 28 June 2019

Funding Type

PhD Type

The aim of this project is to determine the role of inherited refractive error risk factors in the pre-birth development of the eye.
  Functional role of common risk genes in ageing multimorbidity of osteoarthritis and cardiovascular diseases
  Dr H Ismail, Prof M Wilkinson
Application Deadline: 1 August 2019

Funding Type

PhD Type

Osteoarthritis (OA) is a very common musculoskeletal disease and is the leading cause for disability worldwide. It represents a major socio-economic burden in an ageing population with a pressing need for disease-modifying therapies.
  Application of data science to inherited genetic variants of apoptosis genes and susceptibility to breast cancer
  Prof A Cox, Dr K Walters
Application Deadline: 3 July 2019

Funding Type

PhD Type

Background. The identification of the breast and ovarian cancer genes BRCA1 and BRCA2 two decades ago has resulted in both improved patient risk assessment, and the use of PARP-inhibitors for treatment.
  Genetic Epidemiology of Cardiovascular Disease: Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Prof M Farrall, Dr AG Goel
Application Deadline: 26 July 2019

Funding Type

PhD Type

Studying genetic variation in cardiomyopathy and coronary artery disease across the entire allele frequency spectrum in order to identify causative genes and susceptibility loci.
  Using canine models of obesity to discover the mechanisms by which genes influence obesity.
  Dr E Raffan, Dr D Sargan
Applications accepted all year round

Funding Type

PhD Type

We are interested in discovering the mechanisms by which genes influence obesity. The dog is an excellent model organism for human comparative analyses.
  How human teeth form and how that process fails in the inherited condition amelogenesis imperfecta
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Amelogenesis is the process of enamel formation and is essential for the development of functional teeth. Amelogenesis imperfecta (AI) is a failure of that process.
  Social networking: Understanding promiscuity in the transfer of bacterial virulence genes
  Research Group: Institute of Infection, Immunity & Inflammation
  Prof JR Penades
Application Deadline: 1 September 2019

Funding Type

PhD Type

The development of novel multiresistant hypervirulent strains from formerly avirulent or only weakly virulent strains is dramatically fuelled by the acquisition of mobile genetic elements carrying virulence factors.
  How acquisition of antimicrobial resistance genes enhance bacterial colonisation and virulence.
  Dr J Morrissey, Prof P W Andrew, Prof J M Ketley
Applications accepted all year round

Funding Type

PhD Type

The human immune system uses antimicrobial metals as part of its defence mechanism. Excess copper is highly toxic and accumulates at sites of infection and acting within macrophages to kill engulfed pathogens.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Genome and transcriptome sequencing and functional analysis to find new mutation types in patients with inherited blindness
  Prof C Inglehearn
Applications accepted all year round

Funding Type

PhD Type

Human inherited retinal dystrophies (IRDs) result from mutations in over 200 different genes, many of them first implicated by the Leeds Vision Research Group (eg Panagiotou E et al 2017, AJHG 100:960-968; El-Asrag M et al 2015, 96:948-54).
  Characterization and functional analysis of a novel cancer-associated gene
  Dr JP de Magalhaes
Applications accepted all year round

Funding Type

PhD Type

In order to identify new candidate cancer-related genes, our lab developed a bioinformatics “guilt-by-association” method to identify and rank genes that are co-expressed with known cancer-related genes.
  Non-coding RNA regulation of stem cells
  Dr S Brown, Dr P Gokhale
Applications accepted all year round

Funding Type

PhD Type

Stem cells have the potential to make any cell type in the Human body and are powerful tools in drug discovery (Xia and Wong, 2012).
  Clinical Genetics: De Novo Mutations, Selfish Selection, Mosaicism and Human Disease - developing methods for identification of new genes/molecular pathways subject to selfish selection within the human testis
  Prof A Goriely, Prof A Wilkie
Application Deadline: 26 July 2019

Funding Type

PhD Type

De novo mutations (DNMs) are a significant contributor to human disease, affecting ~1:300 new births. We study the mechanisms by which these spontaneous mutations arise in the first instance, concentrating on the tissue where most of them originate, the human testis.
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