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Genetics (php) PhD Projects, Programs & Scholarships

We have 45 Genetics (php) PhD Projects, Programs & Scholarships

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  An improved C. elegans model of Alzheimer’s Disease to monitor neuronal signalling activity
  Research Group: Astbury Centre for Structural Molecular Biology
  Dr P van Oosten-Hawle, Prof N Cohen, Dr S Clapcote
Application Deadline: 31 January 2020

Funding Type

PhD Type

Alzheimer’s Disease (AD) is one of the most common form of neurodegenerative diseases known today, affecting approximately 50 million people worldwide.
  Understanding amyloid aggregation mechanisms of alpha- and gamma synuclein in vitro and in vivo
  Research Group: BBSRC White Rose DTP
  Dr P van Oosten-Hawle, Prof S E Radford
Application Deadline: 6 January 2020

Funding Type

PhD Type

A key pathological hallmark of synucleopathies, including Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS), is the formation of cytotoxic alpha-synuclein and gamma-synuclein aggregates respectively, that lead to neuronal cell death.
  Using CRISPR genome editing to determine the effects of obesity and hypertension associated polymorphisms
  Dr A MacKenzie, Prof M Delibegovic
Applications accepted all year round

Funding Type

PhD Type

Introduction. There is now little doubt that morbid conditions such as obesity, cardiovascular disease and diabetes are mechanistically linked.
  QUADRAT DTP: Environmental ancient DNA analysis of Lateglacial and Early Holocene contexts in Ireland and Scotland
  Dr L Girdland Flink, Dr G Plunkett
Application Deadline: 22 January 2020

Funding Type

PhD Type

This project aims to refine our understanding of Lateglacial and Early Holocene biodiversity and ecosystems in Scotland and Ireland using ancient DNA extracted from ancient sediments (sedimentary ancient DNA, or sedaDNA).
  Adapting to extreme environments: Hybridisation and the evolution of contemporary heavy metal tolerance
  Dr A. Papadopulos, Dr S Creer
Application Deadline: 17 January 2020

Funding Type

PhD Type

Climate change, urbanisation and exploitation of natural resources increasingly alter the environment, posing significant challenges for plants and animals.
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Gene mining useful biocatalysts from paleosols
  Prof C Allen, Dr C Law
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Paleosols are often sediments that are relatively unaffected by the Anthropocene. While there is much research on the microbial community structure found in urban and agricultural soils, these relatively undisturbed soils are very different in a geological and physical context.
  Genome scale evolution of biofilm contained Klebsiella pneumoniae in response to sub-lethal antibacterial stress exposure - development of novel biomarkers for near-patient testing
  Prof S Fanning, Prof B Gilmore
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Klebsiella pneumoniae is an opportunistic pathogenic bacterium found in several niches, being often encountered in a biofilm.
  What drives early-life “programming” in the rumen microbiome?
  Prof C Creevey, Dr K Theodoridou, Prof S Huws
Application Deadline: 16 December 2019

Funding Type

PhD Type

Project details. Manipulation of microorganisms in the rumen of cattle, sheep and deer is a promising strategy for lowering their environmental impact while increasing their efficiency.
  Interneuron Development in the Zebrafish Spinal Cord
  Dr K Lewis
Applications accepted all year round

Funding Type

PhD Type

The Lewis Lab moved to Syracuse University from Cambridge University in the UK in 2010.
  Precision Medicine DTP – Development of clinically relevant models of undifferentiated pleomorphic sarcoma using a genetic screening approach
  Research Group: Edinburgh Cancer Research Centre
  Prof V Brunton, Dr L Boulter, Dr M Taylor, Prof D M Salter
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Sarcomas are relatively uncommon cancers thought to arise from pluripotent mesenchymal stem cells. Undifferentiated pleomorphic soft tissue sarcoma (UPS), though one of the commonest sarcoma subtypes encountered, exemplify the limitations of historical progress in sarcoma therapy.
  Precision Medicine DTP - Dissecting the biophysics of ocular transcription factors in vivo
  Research Group: MRC Human Genetics Unit
  Dr D Papadopoulos, Prof W Bickmore, Prof V Vukojevic
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Of the ~1,600 human TF genes, up to ~25% (~400 genes) are expected to be haploinsufficient with a plethora of them leading to developmental disorders1, underlining that transcription factor (TF) abundance (dosage) plays a major role during cell and tissue specification.
  Precision Medicine DTP - Genomic analysis of the impact of sexual recombination on the segregation of virulence genes in African trypanosomes
  Research Group: The Roslin Institute
  Dr L Morrison, Dr A MacLeod, Dr J Prendergast
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. African trypanosomes are vector-borne protozoa that cause serious human and animal disease across sub-Saharan Africa.
  Precision Medicine DTP - How do IFITM proteins regulate the Interferon Related DNA-damage Resistance Signature (IRDS) and clinical outcomes in cancers of high unmet clinical need?
  Dr R Sloan, Prof K Ball, Dr S Wilson
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Interferon Induced Transmembrane proteins (IFITMs) are a family of innate immune membrane proteins that can inhibit viral infection at cell entry (e.g.
  Precision Medicine DTP - Identification of biomarkers of typical and atypical depression
  Research Group: Centre of Genomic and Experimental Medicine
  Dr P Thomson, Dr R Strawbridge
Application Deadline: 8 January 2020

Funding Type

PhD Type

Background. Major depressive disorder (MDD) is a highly polygenic disorder with hundreds of common risk variants identified through genome-wide association studies of large samples.
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