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Genetics (antimicrobial) PhD Projects, Programs & Scholarships

We have 29 Genetics (antimicrobial) PhD Projects, Programs & Scholarships

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  MRC DiMeN Doctoral Training Partnership: Targeting pathogen subversion of cellular ageing to combat antimicrobial-resistant typhoid fever
  Dr D Humphreys, Prof S Baker, Dr T Darton
Application Deadline: 6 January 2020

Funding Type

PhD Type

- Antimicrobial-resistant typhoid fever is fuelled by chronic Salmonella carriage. The world faces epidemics of untreatable typhoid fever caused by antimicrobial-resistant strains of Salmonella Typhi (~27 million cases/year).
  EASTBIO Genomic epidemiology of bovine mastitis pathogens
  Dr G Paterson, Dr A Macrae, Prof R Fitzgerald
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute. Mastitis, inflammation of the mammary gland, is one of the most common and economically important diseases in dairy cattle.
  GW4 BioMed MRC DTP PhD studentship: Defining the role of efflux in bacterial biofilm formation and antimicrobial resistance to develop new treatments for infection
  Dr B V Jones
Application Deadline: 25 November 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the ‘GW4 BioMed MRC Doctoral Training Partnership’ which is offering up to 18 studentships for entry in September 2020.
  CRISPR-Cas9 gene drives to eradicate antimicrobial resistance from bacterial communities. PhD in Biosciences (SWBio DTP)
  Dr S van Houte
Application Deadline: 2 December 2019

Funding Type

PhD Type

Lead Supervisor. Dr Stineke van Houte, Department of Biosciences, College of Life and Environmental Sciences, University of Exeter.
  (BBSRC DTP) How ecological interactions shape mutation rates to antimicrobial resistance
  Research Group: Ecology and Evolution
  Dr C Knight, Prof A McBain, Dr P Paszek, Dr R Krašovec
Application Deadline: 31 January 2020

Funding Type

PhD Type

The chance that an organism mutates, for instance that a microbe mutates to resist an antibiotic, can depend on that organism’s environment.
  How acquisition of antimicrobial resistance genes enhance bacterial colonisation and virulence.
  Dr J Morrissey, Prof P W Andrew, Prof J M Ketley
Applications accepted all year round

Funding Type

PhD Type

The human immune system uses antimicrobial metals as part of its defence mechanism. Excess copper is highly toxic and accumulates at sites of infection and acting within macrophages to kill engulfed pathogens.
  The maintenance of virulence and antimicrobial resistance in Shigella
  Prof C Tang
Application Deadline: 10 January 2020

Funding Type

PhD Type

Shigella spp are the main cause for dysentery worldwide, and emerged from commensal Escherichia coli following acquisition of a 210 kb virulence plasmid.
  (BBSRC DTP) From mucin biochemistry to pulmonary immunity: How do mucins promote antimicrobial lung defences?
  Prof E Bignell, Prof D Thornton, Dr A Horsley
Application Deadline: 31 January 2020

Funding Type

PhD Type

Respiratory mucus plays multiple essential roles in mammalian lung function, from hydrating the epithelium and supporting gaseous exchange, to expelling inhaled particles and microbes and providing a conduit for innate and adaptive immune signaling.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  MRC DiMeN Doctoral Training Partnership: How to kill a difficult superbug: understanding the evolution of antimicrobial resistance in Clostridioides difficile
  Dr R Fagan, Prof M Brockhurst
Application Deadline: 6 January 2020

Funding Type

PhD Type

Increasing resistance to antibiotics is one of the greatest health challenges facing humanity today. Clostridioides difficile is the primary cause of antibiotic-associated infections in UK hospitals and antibiotic-induced disruption of the gut microbiota is a prerequisite for infection.
  EASTBIO: Application of MinION Nanopore sequencing to understand the impact of environmental changes on sentinel indicators of ecosystem health
  Dr E Watson
Application Deadline: 5 January 2020

Funding Type

PhD Type

We are increasingly aware that human, veterinary and environmental health is intricately linked and farming and food production systems must not only be resilient to environmental changes and threats but the systems themselves must also perform with minimal environmental impact.
  Silver ion-based antimicrobials: mechanisms of toxicity and resistance
  Dr G Mulley, Prof S C Andrews
Applications accepted all year round

Funding Type

PhD Type

"The emergence and persistence of bacterial strains with resistance to multiple classes of antibiotics has led to renewed interest in the antimicrobial properties of silver ions.
  Bacterial iron uptake pathways as targets for the development of novel antimicrobials
  Dr M Thomas
Applications accepted all year round

Funding Type

PhD Type

Antimicrobial resistance is an ever increasing problem. Presently it is estimated to be responsible for 700,000 deaths p.a. and it is predicted that this figure will rise to 10 million by 2050.
  Finding Achilles Heel: Investigating how to control major bacterial pathogens (WEBBERQ20DART)
  Dr M Webber, Prof J Wain
Application Deadline: 2 December 2019

Funding Type

PhD Type

Bacterial infection remains a major cause of morbidity and mortality with hospital acquired infections still common. The increase in numbers of bacterial which are AMR (antimicrobial resistant) makes prevention of infection more important than ever.
  SWBio DTP PhD project: Horizontal transfer of antiviral defences between bacterial species
  Dr T Taylor
Application Deadline: 2 December 2019

Funding Type

PhD Type

This project is one of a number that are in competition for funding from the South West Biosciences Doctoral Training Partnership (SWBio DTP).
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  MRC DiMeN Doctoral Training Partnership: How does the human innate immune system kill the Streptococcus pneumoniae bacterium during infection?
  Dr A Fenton, Dr L Prince
Application Deadline: 6 January 2020

Funding Type

PhD Type

Background. The bacterium Streptococcus pneumoniae is a highly successful human pathogen and a leading cause of pneumonia, a disease responsible for millions of deaths every year.
  Discovery of Antibiotics from Cyanobacteria (TRUMANJ20DTP)
  Dr A Truman
Application Deadline: 25 November 2019

Funding Type

PhD Type

Bacteria have the capacity to produce natural products with exquisite bioactivities, which makes these compounds excellent candidates as medicines and agrochemicals.
  Comparative genomic analysis of variant features within the Neisseria spp.
  Dr L Snyder
Applications accepted all year round

Funding Type

PhD Type

The availability of rapid genome sequencing had generated an explosion of bacterial genome sequence data, much of which has not been fully explored and investigated.
  Investigation of a probiotic strain of Lactobacillus plantarum 2025 and the development of novel antibacterials
  Prof A Karlyshev
Applications accepted all year round

Funding Type

PhD Type

Background. The rise of multidrug resistant forms of microbial pathogens imposes a serious problem to public health worldwide. The rapid spread of antimicrobial resistance is associated with misuse of conventional antibiotics.
  Metals and host-pathogen interactions: the role of metal handling systems in the human gastrointestinal pathogen Campylobacter jejuni
  Dr J Cavet, Dr D Linton
Applications accepted all year round

Funding Type

PhD Type

Campylobacter jejuni is a globally important food-borne pathogen causing an estimated 400-500 million cases of acute human gastroenteritis each year.
  Using synthetic biology to understand the evolution of antibiotic resistance
  Dr M Lagator, Dr C Knight
Applications accepted all year round

Funding Type

PhD Type

Imagine an architect, tasked with converting an old stadium into a building with a different function, without demolishing it.
  Elucidating the emergence of multi-drug resistant Enterococcus faecium
  Prof W Van Schaik, Dr A McNally
Applications accepted all year round

Funding Type

PhD Type

The Gram-positive bacterium Enterococcus faecium is a commensal of the intestinal tract of humans and animals. However, over the last two decades a clone of E.
  EASTBIO Rapid mobile diagnostics for zoonotic pathogens in LMICs
  Dr S Mazeri, Dr A Muwonge, Dr M Bronsvoort
Application Deadline: 5 January 2020

Funding Type

PhD Type

Royal (Dick) School of Veterinary Studies / The Roslin Institute. Zoonotic diseases are a major concern for poor livestock keepers in lower- & middle-income countries (LMICs) where they are exposed to a huge range of pathogens many of animal origin.
  The impact of air pollution on bacteria colonisation and virulence.
  Dr J Morrissey, Prof J Ketley, Prof P W Andrew
Applications accepted all year round

Funding Type

PhD Type

Air pollution is the world’s largest single environmental health risk, being responsible for an eighth of all global deaths per year (World Health Organisation, 2014).
  Alpha-defensin haplotypes and IgA nephropathy risk
  Prof J A L Armour, Prof O Hanotte
Applications accepted all year round

Funding Type

PhD Type

The human alpha-defensin genes DEFA1 and DEFA3 encode short antimicrobial peptides that are important components of the innate immune system, and are subject to copy number variation (CNV) with individuals having between 3 and 18 copies.
  Dissecting the mechanisms of antibiotic resistance in Clostridium difficile
  Dr R Fagan
Applications accepted all year round

Funding Type

PhD Type

Antibiotic resistance in pathogenic bacteria is one of the greatest health challenges facing humanity today.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
  MRC DiMeN Doctoral Training Partnership: Development of an automated analysis pipeline to study bacterial cell wall structure and resistance to beta-lactam antibiotics
  Dr S Mesnage, Dr M Collins
Application Deadline: 6 January 2020

Funding Type

PhD Type

The most widely used antibiotics ever discovered (beta-lactams) are targeting the enzymes that polymerize peptidoglycan (PG), the essential component of the bacterial cell wall.
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