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We have 42 Genetics (cell culture) PhD Projects, Programmes & Scholarships

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Genetics (cell culture) PhD Projects, Programmes & Scholarships

We have 42 Genetics (cell culture) PhD Projects, Programmes & Scholarships

The role of vitamin D3 in treating skin cancer and preventing drug resistance

  Research Group: Chemistry and Biosciences
During the last decade numerous studies have alluded to vitamin D. 3. playing a role in the prevention of cancer. Recent clinical trials looking at the potential role of vitamin D. Read more

Understanding the role of spliceosome gene mutations in disease

The DNA of a cell is copied into a pre-messenger RNA (pre-mRNA) that the cell uses as a template for protein production. Some of the information contained in DNA is not required for making proteins, therefore, unwanted information must be removed before a protein is made. Read more

Experimental and computational Cancer PhD: Overcoming osteosarcoma chemoresistance by characterizing and targeting cellular quiescence

Cancer is the leading cause of death in children and the second in young adults in England and Wales. Sarcomas, tumours that originate from connective tissues (bone, muscle, fat), account for around 15% of childhood cancers. Read more

How to build and maintain a 3-dimensional polarised epithelial sheet

We are interested in how cells maintain normal cell shape within an epithelium. Correct epithelial cell shape is essential to maintain tissue integrity and when deregulated can cause diseases such as malignant cancers, diabetes, inflammation, and aging. Read more

Genetics: Investigating the functional effect of novel genes and genetic variants in malignant hyperthermia susceptibility using model systems

Malignant hyperthermia (MH) is an inherited condition, where patients exposed to anaesthetic drugs are susceptible to a dramatic hyperthermic and hypermetabolic response that can contribute to a significant proportion of post-operative morbidity and deaths. Read more

The impact of nutritional scavenging on host-pathogen interactions, antifungal efficacy and emergence of antifungal resistance

Infections caused by Aspergillus fumigatus (Af) cause more deaths globally than any other fungal disease. Over 20 million are affected annually with four million having life threatening invasive and chronic infections with high morbidity and mortality up to 90%. Read more

The Rhonski project: Examining Rho and Notch signalling in skin development and disease

The skin provides a crucial protective layer between the human body and the outside world. Whilst the epidermis forms a barrier against infection, the inner dermis houses the blood vessels required to sustain the hair follicles and cells contained within both the epidermal and dermal layers. Read more

Metabolic modulation of microglial homeostasis and immune response

Microglia are a specialised immune cell found in the central nervous system. They are responsible for maintaining brain homeostasis and play an important role in the early onset and development of neuroinflammatory disorders such as Alzheimer’s disease. Read more

The use of life course epidemiology to support the experimental characterisation of genetic variation

Project Background. There has been a rapid expansion in the generation of genetic sequence data over the last decade. Understanding the potential relevance of genetic mutations to human health remains challenging. Read more

Chaperones and the response to protein misfolding stress

Misfolded proteins are usually refolded to their functional conformations or degraded by quality control mechanisms. When misfolded proteins evade quality control, they form aggregates that are sequestered to specific sites within cells. Read more
Last chance to apply

PhD studentship - Commercial Applications of Skin Bioenergy Research

Value of award . 100% of Home tuition fees paid and UKRI stipend for annual living expenses.  A successful international candidate needs to fund the difference between the UK and international fees. . Read more

Identifying metabolic drivers of cancer development

Rationale. Growing evidence suggests that cell extrinsic factors are key in modulating tumor progression. Metabolites are small molecules that act as sources of fuel and building blocks essential for cells and tissues when present at normal levels. Read more

MSc by Research: Using genome editing to study the mechanisms of immune cell proliferation and differentiation

T lymphocytes mediate long-term adaptive immunity to viruses and tumour cells. T lymphocytes recognize foreign antigens via specific interactions with the T cell receptor (TCR) that is expressed on the cell surface. Read more

SLS SF4: Identifying pro-longevity drug targets by finding how the nervous system controls aging

Our ageing society is a critical issue. Remaining healthier for longer is a priority with the burden of age-related disease. We want to identify drug targets to develop pro-longevity pharmaceuticals that preserve cognitive function later in life. Read more

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